Home LiteratureArticle Details
PMID: 10781033 Published · ppublish English Comment Journal Article Review

Allosteric activation of the CaR by L-amino acids.

Kobilka B

Abstract

暂无摘要

MeSH Terms
Allosteric Regulation Allosteric Site Amino Acids/pharmacology Calcium/physiology Humans Receptors, Calcium-Sensing Receptors, Cell Surface/chemistry,drug effects,physiology Receptors, GABA-B/physiology
Chemicals
Amino Acids Receptors, Calcium-Sensing Receptors, Cell Surface Receptors, GABA-B Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kobilka B
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology and Division of Cardiovascular Medicine, Stanford University Medical School, Stanford CA 94305, USA. kobilka@cmgm.stanford.edu
References (18)
18 references, click to expand
  1. Calcium sensing properties of the GABA(B) receptor.
    Neuropharmacology. 1999 Nov;38(11):1647-56 PMID: 10587080
  2. Heptahelical receptor signaling: beyond the G protein paradigm.
    J Cell Biol. 1999 May 31;145(5):927-32 PMID: 10352011
  3. L-amino acid sensing by the extracellular Ca2+-sensing receptor.
    Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4814-9 PMID: 10781086
  4. Influence of sodium on the alpha 2-adrenergic receptor system of human platelets. Role for intraplatelet sodium in receptor binding.
    J Biol Chem. 1983 Mar 25;258(6):3913-9 PMID: 6300062
  5. Mutation of an aspartate residue highly conserved among G-protein-coupled receptors results in nonreciprocal disruption of alpha 2-adrenergic receptor-G-protein interactions. A negative charge at amino acid residue 79 forecasts alpha 2A-adrenergic receptor sensitivity to allosteric modulation by monovalent cations and fully effective receptor/G-protein coupling.
    J Biol Chem. 1994 Nov 25;269(47):29557-64 PMID: 7961941
  6. Allosteric modulation of muscarinic acetylcholine receptors.
    Trends Pharmacol Sci. 1995 Jun;16(6):205-12 PMID: 7652930
  7. Metabotropic glutamate receptor 5 is a disulfide-linked dimer.
    J Biol Chem. 1996 Nov 8;271(45):28612-6 PMID: 8910492
  8. Sporadic hypoparathyroidism caused by de Novo gain-of-function mutations of the Ca(2+)-sensing receptor.
    J Clin Endocrinol Metab. 1997 Aug;82(8):2710-5 PMID: 9253358
  9. A Ca(2+)-sensing receptor mutation causes hypoparathyroidism by increasing receptor sensitivity to Ca2+ and maximal signal transduction.
    Pediatr Res. 1997 Oct;42(4):443-7 PMID: 9380434
  10. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
    Nature. 1997 Nov 6;390(6655):88-91 PMID: 9363896
  11. Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor.
    EMBO J. 1997 Nov 17;16(22):6737-47 PMID: 9362488
  12. Structural basis for a Ca2+-sensing function of the metabotropic glutamate receptors.
    Science. 1998 Mar 13;279(5357):1722-5 PMID: 9497291
  13. G protein-coupled receptors. I. Diversity of receptor-ligand interactions.
    J Biol Chem. 1998 Jul 10;273(28):17299-302 PMID: 9651309
  14. Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells.
    J Biol Chem. 1998 Sep 4;273(36):23605-10 PMID: 9722601
  15. GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.
    Nature. 1998 Dec 17;396(6712):674-9 PMID: 9872315
  16. Identification and molecular characterization of m3 muscarinic receptor dimers.
    J Biol Chem. 1999 Jul 2;274(27):19487-97 PMID: 10383466
  17. Heterodimerization is required for the formation of a functional GABA(B) receptor.
    Nature. 1998 Dec 17;396(6712):679-82 PMID: 9872316
  18. GABA(B)-receptor subtypes assemble into functional heteromeric complexes.
    Nature. 1998 Dec 17;396(6712):683-7 PMID: 9872317
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
2000-04-25
Pages
4419-20
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC34312
Subset
IM
Corrections
CommentOn
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com