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PMID: 9497291 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Structural basis for a Ca2+-sensing function of the metabotropic glutamate receptors.

Science (New York, N.Y.) ·Vol. 279 ·No. 5357 ·1998-03-13 ·Pages 1722-5

Kubo Y, Miyashita T, Murata Y

Abstract

The metabotropic glutamate receptors (mGluRs) are widely distributed in the brain and play important roles in synaptic plasticity. Here it is shown that some types of mGluRs are activated not only by glutamate but also by extracellular Ca2+ (Ca2+o). A single amino acid residue was found to determine the sensitivity of mGluRs to Ca2+o. One of the receptors, mGluR1alpha, but not its point mutant with reduced sensitivity to Ca2+o, caused morphological changes when transfected into mammalian cells. Thus, the sensing of Ca2+o by mGluRs may be important in cells under physiological condition.

MeSH Terms

Actins/ultrastructure Amino Acid Sequence Animals Binding Sites Brain/metabolism CHO Cells Calcium/metabolism,pharmacology Cell Size Cricetinae Cyclic AMP/metabolism G Protein-Coupled Inwardly-Rectifying Potassium Channels Glutamic Acid/metabolism,pharmacology Molecular Sequence Data Oocytes Point Mutation Potassium Channels/metabolism Potassium Channels, Inwardly Rectifying Rats Receptors, Metabotropic Glutamate/chemistry,genetics,metabolism Recombinant Fusion Proteins/metabolism Second Messenger Systems Transfection Xenopus laevis

Chemicals

Actins G Protein-Coupled Inwardly-Rectifying Potassium Channels Potassium Channels Potassium Channels, Inwardly Rectifying Receptors, Metabotropic Glutamate Recombinant Fusion Proteins Glutamic Acid Cyclic AMP Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kubo Y

Department of Neurophysiology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2-6, Fuchu, Tokyo 183-8526, Japan. ykubo@tmin.ac.jp

Miyashita T

Murata Y

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.279.5357.1722

ykubo@tmin.ac.jp

Published

1998-03-13

Pages

1722-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.279.5357.1722 View journal details

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Structural basis for a Ca2+-sensing function of the metabotropic glutamate receptors.

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