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PMID: 10735884 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Identification of SopE2, a Salmonella secreted protein which is highly homologous to SopE and involved in bacterial invasion of epithelial cells.

Journal of bacteriology ·Vol. 182 ·No. 8 ·2000-04-00 ·Pages 2341-4

Bakshi CS, Singh VP, Wood MW, Jones PW, Wallis TS, Galyov EE

Abstract

Type III secreted Sop protein effectors are delivered into target eukaryotic cells and elicit cellular responses underlying Salmonella pathogenicity. In this work, we have identified another secreted protein, SopE2, and showed that SopE2 is an important invasion-associated effector. SopE2 is encoded by the sopE2 gene which is present and conserved in pathogenic strains of Salmonella. SopE2 is highly homologous to SopE, a protein encoded by a gene within a temperate bacteriophage and present in only some pathogenic strains.

MeSH Terms
Amino Acid Sequence Bacterial Proteins/metabolism Conserved Sequence Epithelial Cells/microbiology HeLa Cells Humans Molecular Sequence Data Salmonella enterica/genetics,pathogenicity Sequence Homology, Amino Acid
Chemicals
Bacterial Proteins SopE protein, Salmonella
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Bakshi C S
Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom.
Singh V P
Wood M W
Jones P W
Wallis T S
Galyov E E
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.182.8.2341-2344.2000
Published
2000-04-00
Pages
2341-4
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC111290
Subset
IM
Databases
GENBANK
AF200952
External Links
PubMed source DOI: 10.1128/JB.182.8.2341-2344.2000 PMC Full Text View journal details
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