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PMID: 1069295 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Embryonal carcinoma antigen and the T/t locus of the mouse.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 11 ·1976-11-00 ·Pages 4080-4

Kemler R, Babinet C, Condamine H, Gachelin G, Guenet JL, Jacob F

Abstract

The presence of the F9 antigen and of four other antigens related to the T/t locus of the mouse was investigated by immunofluorescence on preimplantation embryos. In morulae heterozygous for any of these t haplotypes, both the appropriate t antigen and the F9 antigen are expressed. The F9 antigen segregates among the progeny of crosses producing embryos homozygous for some (tw32 and tw5) but not for other haplotypes. It is concluded that (i) whatever the time of action of a t haplotype, its corresponding antigen is expressed during cleavage and (ii) the F9 antigen is specified by a gene(s) in the region of the T/t locus.

MeSH Terms
Animals Antigens, Neoplasm Embryo, Mammalian/immunology Embryonic Development Female Genes Heterozygote Male Mice Pregnancy Spermatozoa/immunology
Chemicals
Antigens, Neoplasm
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kemler R
Babinet C
Condamine H
Gachelin G
Guenet J L
Jacob F
References (8)
8 references, click to expand
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    Proc Natl Acad Sci U S A. 1973 Oct;70(10):2988-92 PMID: 4355379
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    Proc Natl Acad Sci U S A. 1974 Mar;71(3):811-4 PMID: 4522792
  5. Similar location of an early embryonic antigen on mouse and human spermatozoa.
    Dev Biol. 1974 Dec;41(2):331-7 PMID: 4615957
  6. Neoplastic differentiation: characteristics of cell lines derived from a murine teratocarcinoma.
    J Cell Physiol. 1974 Aug;84(1):13-27 PMID: 4858519
  7. Complete development in vitro of the pre-implantation stages of the mouse in a simple chemically defined medium.
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  8. Experimental Study of the Developing Mammalian Egg: Removal of the Zona Pellucida.
    Science. 1962 Nov 2;138(3540):594-5 PMID: 17832007
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.11.4080
Published
1976-11-00
Pages
4080-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431335
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.11.4080 PMC Full Text View journal details
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