Primitive teratocarcinoma cells express a differentiation antigen specified by a gene at the T-locus in the mouse.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 3 ·1974-03-00 ·Pages 811-4

Artzt K, Bennett D, Jacob F

Abstract

A cell-surface antigen common to mouse primitive teratocarcinoma cells, morulae, and sperm has been shown by serological methods to be specified by a wild-type T-locus gene whose mutant form is lethal in homozygotes at the morula stage.

MeSH Terms

Alleles Animals Antigens, Neoplasm Cell Membrane/immunology Chromosome Mapping Cytotoxicity Tests, Immunologic Embryo, Mammalian/immunology Genes Genes, Lethal Genotype Germ Layers/immunology Homozygote Male Mice Mutation Spermatozoa/immunology Teratoma/immunology

Chemicals

Antigens, Neoplasm

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Artzt K

Bennett D

Jacob F

References (12)

12 references, click to expand

Surface antigens common to mouse cleavage embryos and primitive teratocarcinoma cells in culture.
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Serological demonstration of H-Y (male) antigen on mouse sperm.
Nature. 1971 Aug 13;232(5311):478-80 PMID: 4937209
Study of the antigenic specificity of Graffi leukemic cells.
J Natl Cancer Inst. 1968 Sep;41(3):743-50 PMID: 4300309
A Second Group of Similar Lethals in Populations of Wild House Mice.
Genetics. 1959 Sep;44(5):795-802 PMID: 17247858
The embryological effects of four late-lethal t-alleles in the mouse, which affect the neural tube and skeleton.
J Morphol. 1959 Jul;105:105-43 PMID: 13798931
Detection of H-2 antigens on mouse spermatozoa by the cytotoxicity test.
Nature. 1970 Nov 7;228(5271):570-2 PMID: 5528693
A genetically caused embryonal ectodermal tumor in the mouse.
J Natl Cancer Inst. 1972 Jan;48(1):141-58 PMID: 4539994
Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.
Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175-93 PMID: 4385242
REPEATED OCCURRENCES IN THE MOUSE OF LETHAL ALLELES OF THE SAME COMPLEMENTATION GROUP.
Genetics. 1964 Jun;49:949-58 PMID: 14181487
ABNORMALITIES ASSOCIATED WITH A CHROMOSOME REGION IN THE MOUSE. II. EMBRYOLOGICAL EFFECTS OF LETHAL ALLELES IN THE T-REGION.
Science. 1964 Apr 17;144(3616):263-7 PMID: 14169710
Serological detection of a cell-surface antigen specified by the T (brachyury) mutant gene in the house mouse.
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2076-80 PMID: 4506076
INVESTIGATIONS OF THE NATURE OF T-ALLELES IN THE MOUSE. II. GENETIC ANALYSIS OF AN UNUSUAL MUTANT ALLELE AND ITS DERIVATIVES.
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.71.3.811

Published

1974-03-00

Pages

811-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388104

Subset

External Links

PubMed source DOI: 10.1073/pnas.71.3.811 PMC Full Text View journal details

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Primitive teratocarcinoma cells express a differentiation antigen specified by a gene at the T-locus in the mouse.

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