Anticancer drug targets: approaching angiogenesis.

The Journal of clinical investigation ·Vol. 104 ·No. 11 ·1999-12-00 ·Pages 1497-501

Keshet E, Ben-Sasson SA

Abstract

暂无摘要

MeSH Terms

Angiogenesis Inhibitors/therapeutic use Angiostatins Animals Antineoplastic Agents/therapeutic use Collagen/pharmacology Endostatins Endothelial Growth Factors/pharmacology Endothelium, Vascular/drug effects Extracellular Matrix/drug effects Humans Lymphokines/pharmacology Neoplasms/blood supply,drug therapy Neovascularization, Pathologic/prevention & control Peptide Fragments/pharmacology Plasminogen/pharmacology Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors

Chemicals

Angiogenesis Inhibitors Antineoplastic Agents Endostatins Endothelial Growth Factors Lymphokines Peptide Fragments Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Angiostatins Plasminogen Collagen

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Keshet E

Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. keshet@cc.huji.ac.il

Ben-Sasson S A

References (27)

27 references, click to expand

The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development.
J Clin Invest. 1999 May;103(9):1227-30 PMID: 10225964
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice.
Science. 1999 Apr 30;284(5415):808-12 PMID: 10221914
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.
Genes Dev. 1999 May 1;13(9):1055-66 PMID: 10323857
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.
Science. 1999 Jun 18;284(5422):1994-8 PMID: 10373119
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis.
Nat Med. 1999 Jul;5(7):793-802 PMID: 10395325
Anti-cancer activity of targeted pro-apoptotic peptides.
Nat Med. 1999 Sep;5(9):1032-8 PMID: 10470080
Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry.
Am J Pathol. 1999 Sep;155(3):739-52 PMID: 10487832
Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.
J Clin Invest. 1999 Dec;104(11):1583-91 PMID: 10587522
Tumor angiogenesis: therapeutic implications.
N Engl J Med. 1971 Nov 18;285(21):1182-6 PMID: 4938153
A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.
Proc Natl Acad Sci U S A. 1990 Sep;87(17):6624-8 PMID: 1697685
Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation.
Cell. 1991 Jan 25;64(2):327-36 PMID: 1703045
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo.
Nature. 1993 Apr 29;362(6423):841-4 PMID: 7683111
Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.
Cell. 1994 Oct 21;79(2):315-28 PMID: 7525077
Definition of two angiogenic pathways by distinct alpha v integrins.
Science. 1995 Dec 1;270(5241):1500-2 PMID: 7491498
Organ targeting in vivo using phage display peptide libraries.
Nature. 1996 Mar 28;380(6572):364-6 PMID: 8598934
Angiostatin induces and sustains dormancy of human primary tumors in mice.
Nat Med. 1996 Jun;2(6):689-92 PMID: 8640562
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.
Cell. 1996 Aug 9;86(3):353-64 PMID: 8756718
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
Cell. 1997 Jan 24;88(2):277-85 PMID: 9008168
Reciprocal paracrine interactions between tumour cells and endothelial cells: the 'angiogenesis progression' hypothesis.
Eur J Cancer. 1996 Dec;32A(14):2438-50 PMID: 9059332
Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia.
Am J Pathol. 1997 Mar;150(3):815-21 PMID: 9060819
The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin.
Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10868-72 PMID: 9380726
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance.
Nature. 1997 Nov 27;390(6658):404-7 PMID: 9389480
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.
Cell. 1998 May 1;93(3):411-22 PMID: 9590175
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
Nature. 1998 Jul 30;394(6692):485-90 PMID: 9697772
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.
Cancer Res. 1999 Jan 1;59(1):99-106 PMID: 9892193
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal.
J Clin Invest. 1999 Jan;103(2):159-65 PMID: 9916127
Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention.
J Clin Invest. 1999 May;103(9):1237-41 PMID: 10225966

Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI8849

keshet@cc.huji.ac.il

Published

1999-12-00

Pages

1497-501

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC409872

Subset

External Links

PubMed source DOI: 10.1172/JCI8849 PMC Full Text View journal details

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Anticancer drug targets: approaching angiogenesis.

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