Home LiteratureArticle Details
PMID: 10584338 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Positive identification of the puberty-accelerating pheromone of the house mouse: the volatile ligands associating with the major urinary protein.

Proceedings. Biological sciences ·Vol. 266 ·No. 1432 ·1999-10-07 ·Pages 2017-22

Novotny MV, Ma W, Wiesler D, Zídek L

Abstract

Five structurally diverse small ligands, all binding to the major urinary protein (MUP) of the male house mouse, show individually puberty-accelerating pheromonal activity in the recipient females. A recombinant MUP (identical structurally to the natural protein) has shown no biological activity. While four of these ligands were previously implicated in oestrus synchronization (Whitten effect), the same chemosignals now appear responsible for both sexual maturation and cycling in adult females.

MeSH Terms
Animals Bridged Bicyclo Compounds, Heterocyclic/chemistry,metabolism Female Ketones/chemistry,metabolism Ligands Male Mice Mice, Inbred ICR Molecular Structure Pheromones/metabolism Proteins/metabolism Recombinant Fusion Proteins/metabolism Sesquiterpenes/chemistry,metabolism Sexual Maturation/physiology Thiazoles/chemistry,metabolism
Chemicals
Bridged Bicyclo Compounds, Heterocyclic Ketones Ligands Pheromones Proteins Recombinant Fusion Proteins Sesquiterpenes Thiazoles major urinary proteins 6-hydroxy-6-methyl-3-heptanone beta-farnesene alpha-farnesene 2-(sec-butyl)-4,5-dihydrothiazole 3,4-dehydrobrevicomin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Novotny M V
Department of Chemistry, Indiana University, Bloomington 47405, USA. novotny@indiana.edu
Ma W
Wiesler D
Zídek L
References (23)
23 references, click to expand
  1. Identification of a testosterone-dependent unique volatile constituent of male mouse urine: 7-exo-ethyl-5-methyl-6,8-dioxabicyclo[3.2.1]-3-octene.
    Experientia. 1984 Feb 15;40(2):217-9 PMID: 6698181
  2. The relationship of the male preputial gland to the acceleration of oestrus in the laboratory mouse.
    J Reprod Fertil. 1974 May;38(1):91-6 PMID: 4858355
  3. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
    Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
  4. Estrus-inducing pheromone of male mice: transport by movement of air.
    Science. 1968 Aug 9;161(3841):584-5 PMID: 5690897
  5. Oestrus-accelerating pheromone of mice: assay, androgen-dependency and presence in bladder urine.
    J Reprod Fertil. 1968 Feb;15(1):131-4 PMID: 5689142
  6. A unique urinary constituent, 6-hydroxy-6-methyl-3-heptanone, is a pheromone that accelerates puberty in female mice.
    Chem Biol. 1999 Jun;6(6):377-83 PMID: 10375540
  7. Major urinary protein complex of normal mice: origin.
    Science. 1965 Aug 27;149(3687):981-2 PMID: 5827345
  8. Differential, multihormonal regulation of the mouse major urinary protein gene family in the liver.
    Mol Cell Biol. 1983 Dec;3(12):2232-40 PMID: 6656765
  9. NMR mapping of the recombinant mouse major urinary protein I binding site occupied by the pheromone 2-sec-butyl-4,5-dihydrothiazole.
    Biochemistry. 1999 Aug 3;38(31):9850-61 PMID: 10433691
  10. Partial isolation of a pheromone accelerating puberty in female mice.
    J Reprod Fertil. 1975 Jun;43(3):515-23 PMID: 1142335
  11. Urine-derived compound evokes membrane responses in mouse vomeronasal receptor neurons.
    J Neurophysiol. 1997 May;77(5):2856-62 PMID: 9163402
  12. Acceleration of puberty onset in female mice by male urinary proteins.
    J Physiol. 1995 Jul 15;486 ( Pt 2):517-22 PMID: 7473215
  13. ESTROUS SYNCHRONY IN MICE: ALTERATION BY EXPOSURE TO MALE URINE.
    Science. 1964 Jun 19;144(3625):1469 PMID: 14171544
  14. Promotion of the Whitten effect in female mice by synthetic analogs of male urinary constituents.
    Proc Natl Acad Sci U S A. 1986 Jun;83(12):4576-9 PMID: 3459193
  15. Synthetic pheromones that promote inter-male aggression in mice.
    Proc Natl Acad Sci U S A. 1985 Apr;82(7):2059-61 PMID: 3856883
  16. Proteins in urine scent marks of male house mice extend the longevity of olfactory signals.
    Anim Behav. 1998 May;55(5):1289-97 PMID: 9632512
  17. Chemistry of male dominance in the house mouse, Mus domesticus.
    Experientia. 1990 Jan 15;46(1):109-13 PMID: 2298278
  18. Socio-sexual olfactory preference in female mice: attractiveness of synthetic chemosignals.
    Physiol Behav. 1991 Dec;50(6):1119-22 PMID: 1798765
  19. Modification of the oestrous cycle of the mouse by external stimuli associated with the male; changes in the oestrous cycle determined by vaginal smears.
    J Endocrinol. 1958 Sep;17(3):307-13 PMID: 13587836
  20. The lipocalin protein family: structure and function.
    Biochem J. 1996 Aug 15;318 ( Pt 1):1-14 PMID: 8761444
  21. Chromatographic separation of puberty accelerating pheromone from male mouse urine.
    Biol Reprod. 1976 Sep;15(2):260-5 PMID: 963152
  22. Induction of estrus in grouped female mice (Mus domesticus) by synthetic analogues of preputial gland constituents.
    Chem Senses. 1999 Jun;24(3):289-93 PMID: 10400447
  23. Male odor accelerates female sexual maturation in mice.
    Endocrinology. 1969 Mar;84(3):658-60 PMID: 5812988
Article Info
Journal
Proceedings. Biological sciences
Abbr.
Proc Biol Sci
ISSN
0962-8452
DOI
10.1098/rspb.1999.0880
Email
novotny@indiana.edu
Published
1999-10-07
Pages
2017-22
Language
English
Region
England
NLM ID
101245157
PMCID
PMC1690305
Subset
IM
Grants
NIDCD NIH HHS · DC 02418 · United States
External Links
PubMed source DOI: 10.1098/rspb.1999.0880 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2