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PMID: 1142335 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Partial isolation of a pheromone accelerating puberty in female mice.

Journal of reproduction and fertility ·Vol. 43 ·No. 3 ·1975-06-00 ·Pages 515-23

Vandenbergh JG, Whitsett JM, Lombardi JR

Abstract

The sexual development of female mice is accelerated by exposure to an adult male or to male urine. The component of the urine responsible for this effect is androgen-dependent, heat labile, nondialysable, precipitatable with ammonium sulphate, and is not extractable in ether. These results indicate that the pheromone causing accelerated sexual development is associated with a protein component of male urine. Tests of the active fraction after digestion with proteolytic enzymes suggest that the pheromone may be a portion of a protein or a substance bound to a protein.

MeSH Terms

Adult Ammonium Sulfate Animals Biological Assay Body Weight/drug effects Chemical Precipitation Dialysis Female Hot Temperature Humans Male Mice Organ Size/drug effects Pheromones/isolation & purification,urine Pronase/metabolism Proteinuria Puberty/drug effects Rats Seasons Solubility Urine/enzymology Uterus/anatomy & histology

Chemicals

Pheromones Pronase Ammonium Sulfate

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Vandenbergh J G

Whitsett J M

Lombardi J R

Article Info

Journal

Journal of reproduction and fertility

Abbr.

J Reprod Fertil

ISSN

0022-4251

DOI

10.1530/jrf.0.0430515

Published

1975-06-00

Pages

515-23

Language

English

Region

England

NLM ID

0376367

Subset

External Links

PubMed source DOI: 10.1530/jrf.0.0430515

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Partial isolation of a pheromone accelerating puberty in female mice.

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