Induction of endogenous and of spleen focus-forming viruses during dimethylsulfoxide-induced differentiation of mouse erythroleukemia cells transformed by spleen focus-forming virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 5 ·1975-05-00 ·Pages 1863-7

Dube SK, Pragnell IB, Kluge N, Gaedicke G, Steinheider G, Ostertag W

Abstract

Spleen focus-forming virus-transformed erythroleukemic cell clones, which have been established by infection of N type mice with NB trophic Friend virus, continue to release biologically active tfriend virus of NB host range. Dimethylsulfoxide induces erythroid differentiation and a 10- to 100-fold increase in the release of biologically active Friend virus. The increase of Friend virus release is a function of the differentiating erythroleukemic cell. The induced Friend viurs is not the NB tropic Friend virus complex, but shows N host range. The induction of the Friend virus complex is due to simultaneous induction of both spleen focus-forming and endogenous viruses.

MeSH Terms

Animals Cell Differentiation/drug effects Cell Line Cell Transformation, Neoplastic Clone Cells Dimethyl Sulfoxide/pharmacology Friend murine leukemia virus/pathogenicity Mice Mice, Inbred Strains Oncogenic Viruses/pathogenicity Species Specificity Spleen/metabolism,microbiology Time Factors

Chemicals

Dimethyl Sulfoxide

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Dube S K

Pragnell I B

Kluge N

Gaedicke G

Steinheider G

Ostertag W

References (20)

20 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.72.5.1863

Published

1975-05-00

Pages

1863-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC432647

Subset

External Links

PubMed source DOI: 10.1073/pnas.72.5.1863 PMC Full Text View journal details

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Induction of endogenous and of spleen focus-forming viruses during dimethylsulfoxide-induced differentiation of mouse erythroleukemia cells transformed by spleen focus-forming virus.

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