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PMID: 10554089 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Therapeutic targets for hypoxia-elicited pathways.

Pharmaceutical research ·Vol. 16 ·No. 10 ·1999-10-00 ·Pages 1498-505

Taylor CT, Colgan SP

Abstract

Diminished oxygen supply to tissues (hypoxia) can stem from many sources, and is a contributing factor to diverse disease processes. Cell and tissue responses to hypoxia are diverse and include dramatic changes in metabolic demand, regulation of cellular gene products, and release of lipid and protein mediators. Surprisingly little attention has been paid to targeted development of therapeutics for hypoxia-related disease processes. This review will focus on recent advances in cellular and molecular biology pertaining to the hypoxia response, and will discuss paradigms used to study hypoxia and the potential targets for therapeutic intervention.

MeSH Terms
Animals Humans Hypoxia/drug therapy,physiopathology Signal Transduction/drug effects,physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Taylor C T
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Colgan S P
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Article Info
Journal
Pharmaceutical research
Abbr.
Pharm Res
ISSN
0724-8741
DOI
10.1023/a:1011936016833
Published
1999-10-00
Pages
1498-505
Language
English
Region
United States
NLM ID
8406521
Subset
IM
Grants
NIDDK NIH HHS · DK02682 · United States
NIDDK NIH HHS · DK50189 · United States
NHLBI NIH HHS · HL60569 · United States
External Links
PubMed source DOI: 10.1023/a:1011936016833 View journal details
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