Activities of telithromycin (HMR 3647, RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin, and other antimicrobial agents against unusual anaerobes.
The comparative activity of telithromycin (HMR 3647) against 419 human anaerobic isolates was determined by the agar dilution method. At concentrations of </=0.5 microgram/ml, telithromycin was active against Actinomyces israelii, Actinomyces odontolyticus, Bacteroides tectum, Bacteroides ureolyticus, Bacteroides gracilis (now Campylobacter gracilis), Porphyromonas spp. (including Porphyromonas gingivalis and Porphyromonas macacae), Prevotella intermedia, Prevotella heparinolytica, and almost all Peptostreptococcus species. Clostridia showed species and strain variability, often with a biphasic pattern. Fusobacterium species, except Fusobacterium russii, were relatively resistant.
10 references, click to expand
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Characterization of saccharolytic Bacteroides and Prevotella isolates from infected dog and cat bite wounds in humans.J Clin Microbiol. 1997 Feb;35(2):406-11 PMID: 9003606
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In vitro evaluation of a novel ketolide antimicrobial agent, RU-64004.Antimicrob Agents Chemother. 1997 Feb;41(2):454-9 PMID: 9021207
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Antimicrobial activity of RU-66647, a new ketolide.Diagn Microbiol Infect Dis. 1997 Jan-Feb;27(1-2):7-12 PMID: 9127099
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The in-vitro activity of HMR 3647, a new ketolide antimicrobial agent.J Antimicrob Chemother. 1998 Dec;42(6):703-9 PMID: 10052892
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Activities of HMR 3004 (RU 64004) and HMR 3647 (RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin, and eight other antimicrobial agents against unusual aerobic and anaerobic human and animal bite pathogens isolated from skin and soft tissue infections in humans.Antimicrob Agents Chemother. 1998 May;42(5):1127-32 PMID: 9593139
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In vitro activity of HMR 3647 against anaerobic bacteria.J Chemother. 1998 Aug;10(4):280-4 PMID: 9720465
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In vitro activity of the new ketolide HMR3647 in comparison with those of macrolides and pristinamycins against Enterococcus spp.Antimicrob Agents Chemother. 1998 Dec;42(12):3279-81 PMID: 9835527
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In vitro activities of ketolide HMR 3647, macrolides, and clindamycin against Coryneform bacteria.Antimicrob Agents Chemother. 1998 Dec;42(12):3290-2 PMID: 9835530
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Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004).Antimicrob Agents Chemother. 1997 Sep;41(9):2019-22 PMID: 9303406
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