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PMID: 9835527 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

In vitro activity of the new ketolide HMR3647 in comparison with those of macrolides and pristinamycins against Enterococcus spp.

Antimicrobial agents and chemotherapy ·Vol. 42 ·No. 12 ·1998-12-00 ·Pages 3279-81

Torres C, Zarazaga M, Tenorio C, Portillo A, Saenz Y, Ruiz F, Baquero F

Abstract

Ninety-four erythromycin-susceptible and 107 erythromycin-resistant enterococcal strains (MIC of >/=512 microgram/ml) were inhibited by the ketolide HMR3647 at MICs of </=0.007 to 0.06 and 0.03 to 8 microgram/ml, respectively. Eighteen vanA-positive isolates and 29 high-level-penicillin-resistant isolates, all of them erythromycin resistant, were inhibited by HMR3647 at an MIC range of 0.015 to 4 microgram/ml. The new ketolide has excellent activity against Enterococcus species.

MeSH Terms

Anti-Bacterial Agents/pharmacology Drug Resistance, Microbial Enterococcus/drug effects,genetics Erythromycin/pharmacology Ketolides Macrolides Microbial Sensitivity Tests Phenotype Virginiamycin/pharmacology

Chemicals

Anti-Bacterial Agents Ketolides Macrolides Virginiamycin Erythromycin telithromycin

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Torres C

Area de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain. carmen.torres@daa.unirioja.es

Zarazaga M

Tenorio C

Portillo A

Saenz Y

Ruiz F

Baquero F

References (7)

7 references, click to expand

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Antibacterial activity of RU 64004 (HMR 3004), a novel ketolide derivative active against respiratory pathogens.
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In vitro activity of RU 64004, a new ketolide antibiotic, against gram-positive bacteria.
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Ketolides lack inducibility properties of MLS(B) resistance phenotype.
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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.42.12.3279

carmen.torres@daa.unirioja.es

Published

1998-12-00

Pages

3279-81

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC106035

Subset

External Links

PubMed source DOI: 10.1128/AAC.42.12.3279 PMC Full Text View journal details

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In vitro activity of the new ketolide HMR3647 in comparison with those of macrolides and pristinamycins against Enterococcus spp.

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