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PMID: 10468613 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 96 ·No. 18 ·1999-08-31 ·Pages 10361-6

Shoshan Y, Nishiyama A, Chang A, Mörk S, Barnett GH, Cowell JK, Trapp BD, Staugaitis SM

Abstract

The early events in neoplastic transformation can be understood only by comparison of the neoplastic cell with its nontransformed counterpart. The most common central nervous system gliomas traditionally are thought to arise from mature astrocytes and oligodendrocytes. We examined the possibility that gliomas arise from a population of glia that has properties of oligodendrocyte progenitors. These glial cells express the NG2 chondroitin sulfate proteoglycan and the alpha receptor of platelet-derived growth factor in vivo. We identified NG2 and the alpha receptor of platelet-derived growth factor expression in tissue from seven of seven oligodendrogliomas, three of three pilocytic astrocytomas, and one of five glioblastoma multiforme. These data provide evidence that glial tumors arise from glial progenitor cells. Molecules expressed by these progenitor cells should be considered as targets for novel therapeutics.

MeSH Terms
Antibodies, Monoclonal Antigens/analysis,genetics Astrocytes/pathology Biopsy Brain/pathology Brain Neoplasms/pathology Cell Transformation, Neoplastic Glioma/pathology Humans Immunohistochemistry Oligodendroglia/pathology Proteoglycans/analysis,genetics Receptor, Platelet-Derived Growth Factor alpha Receptors, Platelet-Derived Growth Factor/analysis,genetics Stem Cells/pathology
Chemicals
Antibodies, Monoclonal Antigens Proteoglycans chondroitin sulfate proteoglycan 4 Receptor, Platelet-Derived Growth Factor alpha Receptors, Platelet-Derived Growth Factor
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Shoshan Y
Department of Neurosciences, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Nishiyama A
Chang A
Mörk S
Barnett G H
Cowell J K
Trapp B D
Staugaitis S M
References (46)
46 references, click to expand
  1. Mitotic activity in the primate subependymal layer and the genesis of gliomas.
    Nature. 1968 Mar 9;217(5132):974-5 PMID: 4966809
  2. Expression of the genes encoding myelin basic protein and proteolipid protein in human malignant gliomas.
    Clin Cancer Res. 1997 May;3(5):799-804 PMID: 9815752
  3. The role of the subependymal plate in glial tumorigenesis.
    Acta Neuropathol. 1977 Sep 26;40(1):63-71 PMID: 199034
  4. Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells.
    Proc Natl Acad Sci U S A. 1982 Feb;79(4):1245-9 PMID: 6175965
  5. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium.
    Nature. 1983 Jun 2-8;303(5916):390-6 PMID: 6304520
  6. Glial fibrillary acidic protein (GFAP) in oligodendroglial tumors: gliofibrillary oligodendroglioma and transitional oligoastrocytoma as subtypes of oligodendroglioma.
    Acta Neuropathol. 1984;64(4):265-72 PMID: 6391068
  7. Surface antigens of melanomas and melanocytes defined by mouse monoclonal antibodies: specificity analysis and comparison of antigen expression in cultured cells and tissues.
    Cancer Res. 1985 Sep;45(9):4401-11 PMID: 4028024
  8. Antigenic expression by cells derived from human gliomas does not correlate with morphological classification.
    Neuropathol Appl Neurobiol. 1987 Sep-Oct;13(5):327-47 PMID: 3317103
  9. Mixed oligodendroglioma and astrocytoma: fine structural and immunohistochemical studies of four cases.
    J Neurol Sci. 1988 Feb;83(2-3):219-25 PMID: 2451711
  10. A role for platelet-derived growth factor in normal gliogenesis in the central nervous system.
    Cell. 1988 Apr 22;53(2):309-19 PMID: 2834067
  11. Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell.
    Nature. 1988 Jun 9;333(6173):560-2 PMID: 3287176
  12. Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture.
    Nature. 1988 Jun 9;333(6173):562-5 PMID: 3287177
  13. Uniform lineage of oligodendrogliomas.
    Am J Pathol. 1989 Sep;135(3):529-40 PMID: 2675625
  14. PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage.
    Development. 1989 Mar;105(3):595-603 PMID: 2558873
  15. Successful chemotherapy for newly diagnosed aggressive oligodendroglioma.
    Ann Neurol. 1990 May;27(5):573-4 PMID: 2360797
  16. The primary structure of NG2, a novel membrane-spanning proteoglycan.
    J Cell Biol. 1991 Jul;114(2):359-71 PMID: 1906475
  17. The expression of NG2 proteoglycan in the developing rat limb.
    Development. 1991 Apr;111(4):933-44 PMID: 1879362
  18. Correlation of chondroitin sulfate proteoglycan expression on proliferating brain capillary endothelial cells with the malignant phenotype of astroglial cells.
    Cancer Res. 1991 Sep 15;51(18):4986-93 PMID: 1893386
  19. PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.
    EMBO J. 1992 Feb;11(2):543-50 PMID: 1311251
  20. Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.
    Cancer Res. 1992 Jun 1;52(11):3213-9 PMID: 1317261
  21. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.
    Cancer Res. 1992 Aug 15;52(16):4550-3 PMID: 1322795
  22. Development and differentiation of glial precursor cells in the rat cerebellum.
    Glia. 1993 Apr;7(4):307-21 PMID: 8320001
  23. High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas.
    Oncogene. 1994 Mar;9(3):949-54 PMID: 8108140
  24. Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma.
    J Neuropathol Exp Neurol. 1995 Jan;54(1):91-5 PMID: 7815084
  25. Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.
    Int J Cancer. 1995 Jan 17;60(2):168-73 PMID: 7829210
  26. Participation of the NG2 proteoglycan in rat aortic smooth muscle cell responses to platelet-derived growth factor.
    Exp Cell Res. 1995 Nov;221(1):231-40 PMID: 7589250
  27. Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas.
    Cancer Res. 1996 Jan 1;56(1):164-71 PMID: 8548759
  28. From rodent glial precursor cell to human glial neoplasia in the oligodendrocyte-type-2 astrocyte lineage.
    Glia. 1995 Nov;15(3):222-30 PMID: 8586459
  29. p53 gene mutations in human astrocytic brain tumors including pilocytic astrocytomas.
    Hum Pathol. 1996 Jun;27(6):586-9 PMID: 8666369
  30. Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells in the developing rat brain.
    J Neurosci Res. 1996 Feb 1;43(3):299-314 PMID: 8714519
  31. Interaction between NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells is required for optimal response to PDGF.
    J Neurosci Res. 1996 Feb 1;43(3):315-30 PMID: 8714520
  32. Glycolipids and myelin proteins in human oligodendrogliomas.
    Glycoconj J. 1996 Jun;13(3):433-43 PMID: 8781974
  33. Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan.
    Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9710-5 PMID: 8790396
  34. Expression of platelet-derived growth factor transcripts in medulloblastomas and ependymomas.
    Pediatr Neurosurg. 1996;24(2):74-8 PMID: 8841077
  35. The NG2 chondroitin sulfate proteoglycan: a multifunctional proteoglycan associated with immature cells.
    Perspect Dev Neurobiol. 1996;3(4):245-59 PMID: 9117258
  36. Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo.
    J Neurosci Res. 1997 Mar 1;47(5):455-70 PMID: 9067855
  37. Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas.
    Cancer. 1997 Apr 1;79(7):1381-93 PMID: 9083161
  38. Stem cells in the central nervous system.
    Science. 1997 Apr 4;276(5309):66-71 PMID: 9082987
  39. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain.
    J Cell Biol. 1997 Apr 21;137(2):459-68 PMID: 9128255
  40. Normal and reactive NG2+ glial cells are distinct from resting and activated microglia.
    J Neurosci Res. 1997 May 15;48(4):299-312 PMID: 9169856
  41. Expression of oligodendrocytic mRNAs in glial tumors: changes associated with tumor grade and extent of neoplastic infiltration.
    Cancer Res. 1997 Sep 15;57(18):4098-104 PMID: 9307299
  42. Platelet-derived growth factor and its receptor expression in human oligodendrogliomas.
    Neurosurgery. 1998 Feb;42(2):341-6 PMID: 9482185
  43. A tripotential glial precursor cell is present in the developing spinal cord.
    Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3996-4001 PMID: 9520481
  44. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas.
    J Natl Cancer Inst. 1998 Oct 7;90(19):1473-9 PMID: 9776413
  45. Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats.
    Nat Biotechnol. 1998 Nov;16(11):1040-4 PMID: 9831032
  46. The origin of experimental brain tumours: a sequential study.
    Experientia. 1976 Nov 15;32(11):1467-8 PMID: 992001
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.96.18.10361
Published
1999-08-31
Pages
10361-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC17893
Subset
IM
Grants
NINDS NIH HHS · R01 NS035058 · United States
NINDS NIH HHS · NS35058 · United States
External Links
PubMed source DOI: 10.1073/pnas.96.18.10361 PMC Full Text View journal details
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