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PMID: 8781974 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Glycolipids and myelin proteins in human oligodendrogliomas.

Glycoconjugate journal ·Vol. 13 ·No. 3 ·1996-06-00 ·Pages 433-43

Sung CC, Collins R, Li J, Pearl DK, Coons SW, Scheithauer BW, Johnson PC, Yates AJ

Abstract

We studied myelin proteins and glycolipids in 24 human oligodendrogliomas (16 pure, eight mixed), including two grade I, 13 grade II, five grade III, and four grade IV. Tumours with a 1b ganglioside content (GD1b, GT1b and GQ1b) over 30% of total gangliosides occur more frequently in the WHO grade I and II (47%) and grade III (40%) than in the grade IV (25%) group; there was no difference in the amounts of total ganglioside or individual gangliosides between pure and mixed oligodendrogliomas. The presence of 6'-LM1 correlated with higher grades of tumours (chi 2 P approximately 0.02); however, 3'-LM1 and total neolacto-series gangliosides did not correlated with grade. Immunohistochemical studies of oligodendrocyte and myelin markers (GalCer, sulfatide, 2',3' -cyclic nucleotide phosphodiesterase, myelin basic protein and proteolipid protein) using specific antibodies showed only a very small proportion of tumour cells staining. These data do not support the hypothesis that tumours classified as oligodendrogliomas are derived from mature oligodendrocytes.

MeSH Terms
Brain Neoplasms/chemistry,pathology Carbohydrate Conformation Carbohydrate Sequence Gangliosides/analysis,biosynthesis,chemistry Glycolipids/analysis,chemistry Humans Immunohistochemistry Molecular Sequence Data Myelin Proteins/analysis N-Acetylneuraminic Acid/analysis Oligodendroglioma/chemistry,pathology
Chemicals
Gangliosides Glycolipids Myelin Proteins N-Acetylneuraminic Acid
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Sung C C
Division of Neuropathology, Ohio State University, Columbus 43210, USA.
Collins R
Li J
Pearl D K
Coons S W
Scheithauer B W
Johnson P C
Yates A J
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Article Info
Journal
Glycoconjugate journal
Abbr.
Glycoconj J
ISSN
0282-0080
DOI
10.1007/BF00731476
Published
1996-06-00
Pages
433-43
Language
English
Region
United States
NLM ID
8603310
Subset
IM
Grants
NINDS NIH HHS · 1P20 NS31087 · United States
NCI NIH HHS · UO1 CA50910 · United States
External Links
PubMed source DOI: 10.1007/BF00731476 View journal details
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