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PMID: 10339614 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Cortical auditory signal processing in poor readers.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 96 ·No. 11 ·1999-05-25 ·Pages 6483-8

Nagarajan S, Mahncke H, Salz T, Tallal P, Roberts T, Merzenich MM

Abstract

Magnetoencephalographic responses recorded from auditory cortex evoked by brief and rapidly successive stimuli differed between adults with poor vs. good reading abilities in four important ways. First, the response amplitude evoked by short-duration acoustic stimuli was stronger in the post-stimulus time range of 150-200 ms in poor readers than in normal readers. Second, response amplitude to rapidly successive and brief stimuli that were identical or that differed significantly in frequency were substantially weaker in poor readers compared with controls, for interstimulus intervals of 100 or 200 ms, but not for an interstimulus interval of 500 ms. Third, this neurological deficit closely paralleled subjects' ability to distinguish between and to reconstruct the order of presentation of those stimulus sequences. Fourth, the average distributed response coherence evoked by rapidly successive stimuli was significantly weaker in the beta- and gamma-band frequency ranges (20-60 Hz) in poor readers, compared with controls. These results provide direct electrophysiological evidence supporting the hypothesis that reading disabilities are correlated with the abnormal neural representation of brief and rapidly successive sensory inputs, manifested in this study at the entry level of the cortical auditory/aural speech representational system(s).

MeSH Terms
Acoustic Stimulation Adult Auditory Cortex/physiology,physiopathology Cerebral Cortex/physiology,physiopathology Dyslexia/physiopathology Electroencephalography Evoked Potentials, Auditory/physiology Female Humans Magnetoencephalography Male Neurons/physiology Reaction Time Reading Reference Values
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Nagarajan S
Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143-07321, USA.
Mahncke H
Salz T
Tallal P
Roberts T
Merzenich M M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.96.11.6483
Published
1999-05-25
Pages
6483-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC26908
Subset
IM
Grants
NINDS NIH HHS · R01 NS010414 · United States
NINDS NIH HHS · NS-10414 · United States
NIDCD NIH HHS · F32 DC000285 · United States
NINDS NIH HHS · F32 NS010414 · United States
NIDCD NIH HHS · F32-DC00285 · United States
External Links
PubMed source DOI: 10.1073/pnas.96.11.6483 PMC Full Text View journal details
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