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PMID: 10212488 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Molecular mechanisms of neurite extension.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences ·Vol. 354 ·No. 1381 ·1999-02-28 ·Pages 387-94

Valtorta F, Leoni C

Abstract

The extension of neurites is a major task of developing neurons, requiring a significant metabolic effort to sustain the increase in molecular synthesis necessary for plasma membrane expansion. In addition, neurite extension involves changes in the subsets of expressed proteins and reorganization of the cytomatrix. These phenomena are driven by environmental cues which activate signal transduction processes as well as by the intrinsic genetic program of the cell. The present review summarizes some of the most recent progress made in the elucidation of the molecular mechanisms underlying these processes.

MeSH Terms
Animals Axons/physiology,ultrastructure Cell Compartmentation Cell Differentiation Cell Polarity Cytoskeleton/physiology Models, Neurological Neurites/physiology,ultrastructure Signal Transduction
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Valtorta F
Department of Neuroscience, San Raffaele Scientific Institute, CNR Center for Cellular and Molecular Pharmacology, Milano, Italy.
Leoni C
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Article Info
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Abbr.
Philos Trans R Soc Lond B Biol Sci
ISSN
0962-8436
DOI
10.1098/rstb.1999.0391
Published
1999-02-28
Pages
387-94
Language
English
Region
England
NLM ID
7503623
PMCID
PMC1692490
Subset
IM
External Links
PubMed source DOI: 10.1098/rstb.1999.0391 PMC Full Text View journal details
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