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PMID: 10198067 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

RacF1, a novel member of the Rho protein family in Dictyostelium discoideum, associates transiently with cell contact areas, macropinosomes, and phagosomes.

Molecular biology of the cell ·Vol. 10 ·No. 4 ·1999-04-00 ·Pages 1205-19

Rivero F, Albrecht R, Dislich H, Bracco E, Graciotti L, Bozzaro S, Noegel AA

Abstract

Using a PCR approach we have isolated racF1, a novel member of the Rho family in Dictyostelium. The racF1 gene encodes a protein of 193 amino acids and is constitutively expressed throughout the Dictyostelium life cycle. Highest identity (94%) was found to a RacF2 isoform, to Dictyostelium Rac1A, Rac1B, and Rac1C (70%), and to Rac proteins of animal species (64-69%). To investigate the role of RacF1 in cytoskeleton-dependent processes, we have fused it at its amino-terminus with green fluorescent protein (GFP) and studied the dynamics of subcellular redistribution using a confocal laser scanning microscope and a double-view microscope system. GFP-RacF1 was homogeneously distributed in the cytosol and accumulated at the plasma membrane, especially at regions of transient intercellular contacts. GFP-RacF1 also localized transiently to macropinosomes and phagocytic cups and was gradually released within <1 min after formation of the endocytic vesicle or the phagosome, respectively. On stimulation with cAMP, no enrichment of GFP-RacF1 was observed in leading fronts, from which it was found to be initially excluded. Cell lines were obtained using homologous recombination that expressed a truncated racF1 gene lacking sequences encoding the carboxyl-terminal region responsible for membrane targeting. These cells displayed normal phagocytosis, endocytosis, and exocytosis rates. Our results suggest that RacF1 associates with dynamic structures that are formed during pinocytosis and phagocytosis. Although RacF1 appears not to be essential, it might act in concert and/or share functions with other members of the Rho family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Carrier Proteins/chemistry,genetics,metabolism Cloning, Molecular Dictyostelium/genetics,physiology Exocytosis GTP-Binding Proteins/chemistry,genetics,metabolism Intercellular Junctions/physiology Molecular Sequence Data Organelles/physiology Phagosomes/physiology Phylogeny Pinocytosis Polymerase Chain Reaction Recombinant Fusion Proteins/chemistry,metabolism Sequence Alignment Sequence Homology, Amino Acid rac GTP-Binding Proteins
Chemicals
Carrier Proteins RacF1 protein, Dictyostelium discoideum Recombinant Fusion Proteins GTP-Binding Proteins rac GTP-Binding Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Rivero F
Institut für Biochemie I, Medizinische Fakultät, Universität zu Köln, 50931 Köln, Germany.
Albrecht R
Dislich H
Bracco E
Graciotti L
Bozzaro S
Noegel A A
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Article Info
Journal
Molecular biology of the cell
Abbr.
Mol Biol Cell
ISSN
1059-1524
Published
1999-04-00
Pages
1205-19
Language
English
Region
United States
NLM ID
9201390
PMCID
PMC25253
Subset
IM
Databases
GENBANK
AF037042
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