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PMID: 10193420 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Expression of killer inhibitory receptors on cytotoxic cells from HIV-1-infected individuals.

Clinical and experimental immunology ·Vol. 115 ·No. 3 ·1999-03-00 ·Pages 472-6

Galiani MD, Aguado E, Tarazona R, Romero P, Molina I, Santamaria M, Solana R, Peña J

Abstract

Dysfunction of cytotoxic activity of T and natural killer (NK) lymphocytes is a main immunological feature in patients with AIDS, but its basis are not well understood. It has been recently described that T and NK cell-mediated cytotoxicity can be regulated by HLA killer inhibitory receptors (KIR). In this work, we have determined on cytotoxic T cells and NK cells from HIV-1-infected individuals the expression of the following KIR molecules: p58, p70, and ILT2 (immunoglobulin-like family KIR) as well as CD94 and NKG2A (C-lectin-type family KIR). With some exceptions, no significant changes were found on the expression of immunoglobulin-like KIR in either CD8+ or CD56+ cells. Interestingly, the percentages of CD8+ and CD56+ cells expressing CD94 were significantly increased in these individuals. We also show that, in vitro, IL-10 up-regulates CD94 expression on CD8+ and CD56+ cells obtained from normal individuals, suggesting that the augmented expression observed in HIV-infected individuals could be related to the high levels of IL-10 previously described in HIV-1-infected individuals.

MeSH Terms
Antigens, CD/metabolism CD56 Antigen/metabolism CD8-Positive T-Lymphocytes/immunology Case-Control Studies HIV Infections/immunology HIV-1 Humans In Vitro Techniques Interleukin-10/metabolism,pharmacology Killer Cells, Natural/immunology Lectins, C-Type Membrane Glycoproteins/metabolism NK Cell Lectin-Like Receptor Subfamily D Receptors, Immunologic/metabolism Receptors, KIR Receptors, KIR2DL3 T-Lymphocytes, Cytotoxic/immunology
Chemicals
Antigens, CD CD56 Antigen KIR2DL3 protein, human KLRD1 protein, human Lectins, C-Type Membrane Glycoproteins NK Cell Lectin-Like Receptor Subfamily D Receptors, Immunologic Receptors, KIR Receptors, KIR2DL3 Interleukin-10
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Galiani M D
Departamento de Inmunología, Facultad de Medicina, Hospital Reina Sofía, Spain.
Aguado E
Tarazona R
Romero P
Molina I
Santamaria M
Solana R
Peña J
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33 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
DOI
10.1046/j.1365-2249.1999.00833.x
Published
1999-03-00
Pages
472-6
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1905253
Subset
IM
External Links
PubMed source DOI: 10.1046/j.1365-2249.1999.00833.x PMC Full Text View journal details
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