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PMID: 9212363 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The CD94/NKG2 C-type lectin receptor complex: involvement in NK cell-mediated recognition of HLA class I molecules.

Immunologic research ·Vol. 16 ·No. 2 ·1997-00-00 ·Pages 175-85

López-Botet M, Carretero M, Pérez-Villar J, Bellón T, Llano M, Navarro F

Abstract

A multigene family to human Ig-SF receptors and members of the murine Ly49 C-type lectin family are involved in natural killer (NK) cell-mediated recognition of MHC class I molecules. The human CD94 glycoprotein covalently assembles with different C-type lectins of the NKG2 family. By functional criteria, the CD94/NKG2-A (kp43) receptor complex appears also involved in NK cell-mediated recognition of different HLA class I allotypes. Similarly to the other NK inhibitory receptors, NKG2-A contains cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMS). By contrast, NK clones bearing different receptor complex (CD94/p39) are triggered upon ligation by CD94-specific monoclonal antibodies (MAbs); the p39 subunit is likely encoded by other member(s) of the NKG2 family. Expression of different CD94/NKG2 complexes is warranted to precisely assess their specific interaction with HLA class I molecules, and the molecular basis for their divergent functional properties.

MeSH Terms
Animals Antigens, CD/metabolism Cytotoxicity, Immunologic Histocompatibility Antigens Class I/metabolism Humans Killer Cells, Natural/metabolism Lectins, C-Type Membrane Glycoproteins/metabolism NK Cell Lectin-Like Receptor Subfamily C NK Cell Lectin-Like Receptor Subfamily D Receptors, Immunologic Receptors, Mitogen Receptors, Natural Killer Cell
Chemicals
Antigens, CD Histocompatibility Antigens Class I KLRC1 protein, human KLRC2 protein, human KLRD1 protein, human Lectins, C-Type Membrane Glycoproteins NK Cell Lectin-Like Receptor Subfamily C NK Cell Lectin-Like Receptor Subfamily D Receptors, Immunologic Receptors, Mitogen Receptors, Natural Killer Cell
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
López-Botet M
Hospital de la Princesa, Universidad Autónoma de Madrid, Spain. mlbotet/princesa@hup.es
Carretero M
Pérez-Villar J
Bellón T
Llano M
Navarro F
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
0257-277X
DOI
10.1007/BF02786361
Email
princesa@hup.es
Published
1997-00-00
Pages
175-85
Language
English
Region
United States
NLM ID
8611087
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02786361 View journal details
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