Evidence for stimulation of 5-HT receptors in canine saphenous arteries by ergotamine.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 295 ·No. 1 ·1976-10-00 ·Pages 41-4

Müller-Schweinitzer E

Abstract

Changes in tension of spiral strips from dog saphenous arteries were monitored isometrically. Dose-response curves for noradrenaline, 5-HT and ergotamine were established without and after a 30 min incubation with phentolamine or pizotifen. Phentolamine was about 15 times more potent in antagonizing responses to noradrenaline (pA2 value=7.4) than those to 5-HT (pA2 value=6.2) but it was nearly equipotent in antagonizing responses to ergotamine (pA2 value=6.5) and those to 5-HT. Pizotifen was about 500 times less potent in antagonizing noradrenaline effects than 5-HT but again nearly equipotent when tested against ergotamine and 5-HT. It is suggested that in canine saphenous arteries the stimulant activity of ergotamine is mediated mainly through 5-HT receptors.

MeSH Terms

Animals Arteries/drug effects Dogs Ergotamine/antagonists & inhibitors,pharmacology Female Male Norepinephrine/pharmacology Phentolamine/pharmacology Pizotyline/pharmacology Receptors, Serotonin/drug effects Serotonin/pharmacology Vasomotor System/drug effects

Chemicals

Receptors, Serotonin Pizotyline Serotonin Ergotamine Norepinephrine Phentolamine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Müller-Schweinitzer E

References (8)

8 references, click to expand

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Article Info

Journal

Naunyn-Schmiedeberg's archives of pharmacology

Abbr.

Naunyn Schmiedebergs Arch Pharmacol

ISSN

0028-1298

DOI

10.1007/BF00509770

Published

1976-10-00

Pages

41-4

Language

English

Region

Germany

NLM ID

0326264

Subset

External Links

PubMed source DOI: 10.1007/BF00509770 View journal details

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Evidence for stimulation of 5-HT receptors in canine saphenous arteries by ergotamine.

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