ZC3H12A (zinc finger CCCH-type containing 12A)

基因基本信息

基因基本信息

symbol:
ZC3H12A
locus group:
protein-coding gene
location:
1p34.3
gene_family:
Zinc fingers, CCCH-type
alias symbol:
FLJ23231|MCPIP1|Regnase-1
alias name:
MCP induced protein 1
entrez id:
80149
ensembl gene id:
ENSG00000163874
ucsc gene id:
uc001cbb.5
refseq accession:
NM_025079
hgnc_id:
HGNC:26259
approved reserved:
2005-06-03

基因染色体位置

基因染色体位置

1p34.3
基因染色体位置图

基因简述

基因简述

ZC3H12A，也称为MCPIP1（单核细胞趋化蛋白诱导蛋白1），是一个重要的免疫调节基因，属于ZC3H12基因家族。这个家族共有四个成员（ZC3H12A-D），它们都含有CCCH型锌指结构域，具有RNA结合能力，参与调控炎症反应和免疫稳态。ZC3H12A的主要功能包括作为核糖核酸酶降解特定mRNA（如炎症因子IL-6、IL-12p40的mRNA），并通过抑制NF-κB和AP-1信号通路负调控炎症反应。它在免疫细胞（如巨噬细胞、树突细胞）中高表达，是先天免疫和获得性免疫的关键调节因子。ZC3H12A的突变或功能缺失会导致严重的自身炎症性疾病，如幼年型关节炎和炎症性肠病，因为无法有效抑制炎症因子的产生。过表达ZC3H12A会过度抑制免疫反应，可能增加感染风险或导致免疫缺陷；而表达降低则与慢性炎症、动脉粥样硬化、肥胖相关代谢紊乱甚至癌症（如肝癌、乳腺癌）的发展密切相关。该基因还通过调控血管生成因子（如VEGF）影响心血管疾病进程，并通过microRNA调控网络参与细胞凋亡和自噬。ZC3H12家族成员的共性是均含有保守的CCCH锌指结构和PIN-like核糖核酸酶域，但ZC3H12A的核糖核酸酶活性最强，使其成为家族中最重要的炎症调控者。研究显示，ZC3H12A还与病毒感染（如HIV、HCV）的宿主防御有关，能降解病毒RNA。在神经系统中，它的异常表达还与神经退行性疾病相关。这些多重功能使ZC3H12A成为炎症性疾病和癌症治疗的潜在靶点，目前正在探索通过小分子药物或基因疗法调控其活性的治疗策略。

ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]

None

OMIM数据库中对ZC3H12A基因的介绍     Wikipedia数据库中对ZC3H12A基因的介绍

基因序列

基因序列

ZC3H12A基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

ZC3H12A基因的碱基突变：           仅显示部分snp
rs1395718       rs2456802       rs2456803       rs2492301       rs2660565       rs2660566       rs2783729       rs2783730       rs3766277       rs6681785       rs12078925       rs12124878       rs12739756       rs34702192       rs34796867       rs41267297       rs72657763      

基因表达

基因表达

ZC3H12A基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAGTGTTTGTGCCATCCTG
60
GTGATGGTGTGAACACCAG
59
GTCAATGACAAGTTTATGCCC
58
AAAGTGAGTGGCTTCTTACG
58
ATCACAGACCAGCACATCC
60
GTCGTGATGGTGTGAACAC
59
GTCAATGACAAGCTTGCCA
59
GAGGGTGCAAAGAACTCTC
58
ACAGTGTTTGTGCCATCCT
60
GATGGTGTGAACACCAGGA
60
CGTCAATGACAAGTTTATGCC
58
AAGTGAGTGGCTTCTTACG
58
ATCACAGACCAGCACATCC
60
GTGATGGTGTGAACACCAG
59
AATGACAAGCTTGCCATCG
59
CAGAGGGTGCAAAGAACTC
59
CAGTGTTTGTGCCATCCTG
60
GATGGTGTGAACACCAGGA
60
ATCACAGACCAGCACATCC
60
GATGGTGTGAACACCAGGA
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

ZC3H12A基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

ZC3H12A基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000294
Q5D1E8 (UniProtKB)
ISS
GO:0000932
Q5D1E8 (UniProtKB)
IDA
GO:0000932
Q5D1E8 (UniProtKB)
IDA
GO:0001525
Q5D1E8 (UniProtKB)
IEA
GO:0001933
Q5D1E8 (UniProtKB)
ISS
GO:0002230
Q5D1E8 (UniProtKB)
IDA
GO:0003677
Q5D1E8 (UniProtKB)
IDA
GO:0003682
Q5D1E8 (UniProtKB)
IDA
GO:0003723
Q5D1E8 (UniProtKB)
IDA
GO:0003729
Q5D1E8 (UniProtKB)
IDA
GO:0003730
Q5D1E8 (UniProtKB)
ISS
GO:0004521
Q5D1E8 (UniProtKB)
ISS
GO:0004532
Q5D1E8 (UniProtKB)
ISS
GO:0004540
Q5D1E8 (UniProtKB)
IDA
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005515
Q5D1E8 (UniProtKB)
IPI
GO:0005634
Q5D1E8 (UniProtKB)
IDA
GO:0005654
Q5D1E8 (UniProtKB)
IDA
GO:0005737
Q5D1E8 (UniProtKB)
IDA
GO:0005737
Q5D1E8 (UniProtKB)
IDA
GO:0005737
Q5D1E8 (UniProtKB)
IDA
GO:0005791
Q5D1E8 (UniProtKB)
ISS
GO:0005856
Q5D1E8 (UniProtKB)
IDA
GO:0005886
Q5D1E8 (UniProtKB)
IDA
GO:0006351
Q5D1E8 (UniProtKB)
IEA
GO:0006915
Q5D1E8 (UniProtKB)
IEA
GO:0006954
Q5D1E8 (UniProtKB)
IEA
GO:0007399
Q5D1E8 (UniProtKB)
IEA
GO:0010468
Q5D1E8 (UniProtKB)
IDA
GO:0010508
Q5D1E8 (UniProtKB)
IDA
GO:0010595
Q5D1E8 (UniProtKB)
IDA
GO:0010628
Q5D1E8 (UniProtKB)
IDA
GO:0010629
Q5D1E8 (UniProtKB)
IDA
GO:0010656
Q5D1E8 (UniProtKB)
ISS
GO:0010884
Q5D1E8 (UniProtKB)
IDA
GO:0010942
Q5D1E8 (UniProtKB)
IDA
GO:0016579
Q5D1E8 (UniProtKB)
IDA
GO:0030154
Q5D1E8 (UniProtKB)
IEA
GO:0030867
Q5D1E8 (UniProtKB)
IEA
GO:0032088
Q5D1E8 (UniProtKB)
IDA
GO:0032715
Q5D1E8 (UniProtKB)
IDA
GO:0032720
Q5D1E8 (UniProtKB)
IDA
GO:0034599
Q5D1E8 (UniProtKB)
ISS
GO:0035198
Q5D1E8 (UniProtKB)
IDA
GO:0035613
Q5D1E8 (UniProtKB)
ISS
GO:0035925
Q5D1E8 (UniProtKB)
ISS
GO:0036459
Q5D1E8 (UniProtKB)
IEA
GO:0042149
Q5D1E8 (UniProtKB)
ISS
GO:0042307
Q5D1E8 (UniProtKB)
IDA
GO:0042347
Q5D1E8 (UniProtKB)
ISS
GO:0042406
Q5D1E8 (UniProtKB)
ISS
GO:0043022
Q5D1E8 (UniProtKB)
ISS
GO:0043031
Q5D1E8 (UniProtKB)
IC
GO:0043124
Q5D1E8 (UniProtKB)
ISS
GO:0044828
Q5D1E8 (UniProtKB)
IDA
GO:0045019
Q5D1E8 (UniProtKB)
IDA
GO:0045600
Q5D1E8 (UniProtKB)
IDA
GO:0045766
Q5D1E8 (UniProtKB)
IDA
GO:0045766
Q5D1E8 (UniProtKB)
IMP
GO:0045944
Q5D1E8 (UniProtKB)
IDA
GO:0045944
Q5D1E8 (UniProtKB)
IDA
GO:0046872
Q5D1E8 (UniProtKB)
IEA
GO:0050713
Q5D1E8 (UniProtKB)
ISS
GO:0051259
Q5D1E8 (UniProtKB)
IDA
GO:0051259
Q5D1E8 (UniProtKB)
IDA
GO:0051607
Q5D1E8 (UniProtKB)
IEA
GO:0055118
Q5D1E8 (UniProtKB)
ISS
GO:0061014
Q5D1E8 (UniProtKB)
ISS
GO:0061014
Q5D1E8 (UniProtKB)
IDA
GO:0061158
Q5D1E8 (UniProtKB)
ISS
GO:0061158
Q5D1E8 (UniProtKB)
IDA
GO:0071222
Q5D1E8 (UniProtKB)
IDA
GO:0071222
Q5D1E8 (UniProtKB)
IDA
GO:0071222
Q5D1E8 (UniProtKB)
IDA
GO:0071347
Q5D1E8 (UniProtKB)
ISS
GO:0071356
Q5D1E8 (UniProtKB)
IDA
GO:0090501
Q5D1E8 (UniProtKB)
ISS
GO:0090502
Q5D1E8 (UniProtKB)
IDA
GO:0090503
Q5D1E8 (UniProtKB)
IEA
GO:0098586
Q5D1E8 (UniProtKB)
IDA
GO:1900016
Q5D1E8 (UniProtKB)
ISS
GO:1900119
Q5D1E8 (UniProtKB)
ISS
GO:1900165
Q5D1E8 (UniProtKB)
ISS
GO:1900745
Q5D1E8 (UniProtKB)
IDA
GO:1902714
Q5D1E8 (UniProtKB)
ISS
GO:1903799
Q5D1E8 (UniProtKB)
IDA
GO:1903936
Q5D1E8 (UniProtKB)
ISS
GO:1904468
Q5D1E8 (UniProtKB)
ISS
GO:1904628
Q5D1E8 (UniProtKB)
IDA
GO:1904637
Q5D1E8 (UniProtKB)
ISS
GO:1990869
Q5D1E8 (UniProtKB)
IDA
GO:1990869
Q5D1E8 (UniProtKB)
IDA
GO:2000379
Q5D1E8 (UniProtKB)
IDA
GO:2000627
Q5D1E8 (UniProtKB)
IDA
GO:2000627
Q5D1E8 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 ZC3H12A基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

MINT

BioGrid

IntAct

mentha

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Arterial Occlusive Diseases 0.12 1 0 CTD_human
Myocardial Ischemia 0.002995792 1 0 BeFree_LHGDN
Degenerative polyarthritis 0.000542884 2 0 BeFree
Middle Cerebral Artery Occlusion 0.000271442 1 0 BeFree
Virus Diseases 0.000271442 1 0 BeFree
Mycoses 0.000271442 1 0 BeFree
Infection by Candida albicans 0.000271442 1 0 BeFree
Immune System Diseases 0.000271442 1 0 BeFree
Autoimmune Diseases 0.000271442 1 0 BeFree
Ischemic Cerebrovascular Accident 0.000271442 1 0 BeFree

基因相关服务

基因相关服务

联系方式

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