YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)

基因基本信息

基因基本信息

symbol:
YWHAZ
locus group:
protein-coding gene
location:
8q22.3
gene_family:
alias symbol:
KCIP-1|14-3-3-zeta
alias name:
14-3-3 zeta|14-3-3 delta
entrez id:
7534
ensembl gene id:
ENSG00000164924
ucsc gene id:
uc064pcn.1
refseq accession:
NM_145690
hgnc_id:
HGNC:12855
approved reserved:
1993-09-20

基因染色体位置

基因染色体位置

8q22.3
基因染色体位置图

基因简述

基因简述

YWHAZ（酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白zeta）属于14-3-3蛋白家族，这是一个高度保守的调控蛋白家族，其成员通过结合磷酸化靶蛋白参与多种细胞过程。14-3-3蛋白家族的共性包括形成同源或异源二聚体，通过特异性识别磷酸化丝氨酸/苏氨酸基序调控底物蛋白的定位、稳定性及活性。YWHAZ作为该家族成员，主要作为分子支架或适配蛋白发挥作用，其表达产物通过与数百种客户蛋白（client proteins）相互作用参与细胞周期调控、凋亡抑制、信号转导（如PI3K/AKT、MAPK通路）及代谢调节。该基因在几乎所有组织中广泛表达，作用位点包括细胞质、线粒体及细胞核，通过调控CDC25、BAD、FOXO等关键蛋白影响细胞增殖与存活。突变可能导致其磷酸化结合能力受损，与癌症（如乳腺癌、肺癌）、神经退行性疾病及自身免疫疾病相关。过表达会增强抗凋亡效应并促进肿瘤发生，同时可能通过稳定β-连环蛋白（β-catenin）激活WNT通路；而敲低表达则导致细胞周期阻滞、增加凋亡敏感性，并可能影响神经元突触可塑性。在阿尔茨海默病中观察到YWHAZ与tau蛋白异常相互作用，在乳腺癌中其过表达与HER2阳性亚型和化疗耐药相关。该基因的调控具有剂量敏感性，表达水平微小变化即可显著影响多条信号通路的平衡，这使其成为潜在的治疗靶点但同时也增加了靶向干预的复杂性。

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

该基因产物属于14-3-3家族，通过结合含有磷酸丝氨酸蛋白介导的信号转导的蛋白质。此高度保守的蛋白家族在植物和哺乳动物中发现，而该蛋白质是99％相同的小鼠，大鼠和绵羊直向同源物。所编码的蛋白质与IRS1蛋白相互作用，这表明在调节胰岛素敏感性的作用。在5‘端非编码区不同，但编码相同的蛋白的几个转录变体已被确定为这个基因。 [由RefSeq的，2008年10月提供]

OMIM数据库中对YWHAZ基因的介绍     Wikipedia数据库中对YWHAZ基因的介绍

基因序列

基因序列

YWHAZ基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

YWHAZ基因的碱基突变：           仅显示部分snp
rs964917       rs964919       rs983583       rs1062376       rs1062382       rs1376672       rs1451637       rs1470764       rs1901362       rs2290291       rs3100052       rs3100053       rs3100054       rs3105452       rs3105460       rs3134352       rs3134353      

基因表达

基因表达

YWHAZ基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TCTGCAATGATGTACTGTCTC
58
GCCAAGTAACGGTAGTAATCTC
59
GGACACAGAACATCCAGTC
58
TGTCATCATATCGCTCAGC
58
GGTGATGACAAGAAAGTACGT
58
ATGTGTTGGTTGCATTTCCT
59
TCTGGCCCTTAACTTCTCTG
59
TGTCCACAATGTCAAGTTGTC
59
GACAAGAAAGGGATTGTCGA
58
TGTGTTGGTTGCATTTCCT
58
TCTGCAATGATGTACTGTCTC
58
GCCAAGTAACGGTAGTAATCTC
59
TCTGCAATGATGTACTGTCTC
58
GCCAAGTAACGGTAGTAATCTC
59
TCTGCAATGATGTACTGTCTC
58
GCCAAGTAACGGTAGTAATCTC
59
TCTGCAATGATGTACTGTCTC
58
GCCAAGTAACGGTAGTAATCTC
59
TCTGGCCCTTAACTTCTCTG
59
TGTCCACAATGTCAAGTTGTC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

YWHAZ基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

YWHAZ基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0019904
B0AZS6 (UniProtKB)
IEA
GO:0016301
B7Z2E6 (UniProtKB)
IEA
GO:0016310
B7Z2E6 (UniProtKB)
IEA
GO:0019904
B7Z2E6 (UniProtKB)
IEA
GO:0019904
E5RGE1 (UniProtKB)
IEA
GO:0019904
E5RIR4 (UniProtKB)
IEA
GO:0019904
E7ESK7 (UniProtKB)
IEA
GO:0019904
E7EVZ2 (UniProtKB)
IEA
GO:0019904
E7EX29 (UniProtKB)
IEA
GO:0019904
E9PD24 (UniProtKB)
IEA
GO:0019904
H0YB80 (UniProtKB)
IEA
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005515
P63104 (UniProtKB)
IPI
GO:0005615
P63104 (UniProtKB)
IDA
GO:0005615
P63104 (UniProtKB)
IDA
GO:0005634
P63104 (UniProtKB)
IDA
GO:0005654
P63104 (UniProtKB)
TAS
GO:0005654
P63104 (UniProtKB)
TAS
GO:0005654
P63104 (UniProtKB)
TAS
GO:0005654
P63104 (UniProtKB)
TAS
GO:0005737
P63104 (UniProtKB)
TAS
GO:0005739
P63104 (UniProtKB)
IEA
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005829
P63104 (UniProtKB)
TAS
GO:0005925
P63104 (UniProtKB)
IDA
GO:0006605
P63104 (UniProtKB)
IEA
GO:0007165
P63104 (UniProtKB)
TAS
GO:0008134
P63104 (UniProtKB)
IPI
GO:0019901
P63104 (UniProtKB)
IPI
GO:0019904
P63104 (UniProtKB)
IEA
GO:0030168
P63104 (UniProtKB)
TAS
GO:0030659
P63104 (UniProtKB)
TAS
GO:0031625
P63104 (UniProtKB)
IPI
GO:0042470
P63104 (UniProtKB)
IEA
GO:0042802
P63104 (UniProtKB)
IPI
GO:0042802
P63104 (UniProtKB)
IPI
GO:0043066
P63104 (UniProtKB)
TAS
GO:0043488
P63104 (UniProtKB)
TAS
GO:0044822
P63104 (UniProtKB)
IDA
GO:0051683
P63104 (UniProtKB)
IMP
GO:0061024
P63104 (UniProtKB)
TAS
GO:0070062
P63104 (UniProtKB)
IDA
GO:0070062
P63104 (UniProtKB)
IDA
GO:0070062
P63104 (UniProtKB)
IDA
GO:0070062
P63104 (UniProtKB)
IDA
GO:0072562
P63104 (UniProtKB)
IDA
GO:0090168
P63104 (UniProtKB)
IMP
GO:1900740
P63104 (UniProtKB)
TAS

基因相关microRNA

基因相关microRNA

可能调控 YWHAZ基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neoplasm Recurrence, Local 0.12 1 0 CTD_human
IGA Glomerulonephritis 0.12 1 0 CTD_human
Mammary Neoplasms, Experimental 0.12 1 0 CTD_human
Animal Mammary Neoplasms 0.12 1 0 CTD_human
Seizures 0.08 1 0 RGD
Dehydration 0.08 1 0 RGD
Absence Epilepsy 0.08 1 0 RGD
Hypertensive disease 0.08 1 0 RGD
Alzheimer's Disease 0.005634266 4 0 BeFree_GAD_LHGDN
Atherosclerosis 0.004624443 8 0 BeFree_LHGDN

基因相关服务

基因相关服务

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