YES1 (YES proto-oncogene 1, Src family tyrosine kinase)

基因基本信息

基因基本信息

symbol:
YES1
locus group:
protein-coding gene
location:
18p11.32
gene_family:
SH2 domain containing
alias symbol:
Yes|c-yes|HsT441
alias name:
None
entrez id:
7525
ensembl gene id:
ENSG00000176105
ucsc gene id:
uc002kkz.4
refseq accession:
NM_005433
hgnc_id:
HGNC:12841
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

18p11.32
基因染色体位置图

基因简述

基因简述

YES1基因属于SRC基因家族，这是一个编码非受体型酪氨酸激酶的家族，其成员在细胞信号转导中起关键作用，通过磷酸化靶蛋白调控细胞增殖、分化、迁移和存活。YES1编码的蛋白与SRC激酶结构相似，包含SH3（调控蛋白相互作用）、SH2（结合磷酸化酪氨酸）和激酶结构域（催化磷酸化反应），主要定位于细胞膜内侧和细胞黏附连接处，参与整合素介导的细胞黏附信号和生长因子受体（如EGFR）下游通路。该基因的激活依赖C端酪氨酸残基（Y537）的去磷酸化，而激酶活性受CSK等激酶的抑制性磷酸化调控。功能上，YES1在胚胎发育中调节组织形态发生，成年后在上皮细胞、神经元和免疫细胞中维持稳态，例如促进紧密连接形成、突触可塑性及B细胞活化。突变可能导致功能获得（如激酶区突变增强活性）或功能丧失（如截短突变），前者与肿瘤发生相关（如结肠癌、肺癌中YES1扩增或突变导致增殖和侵袭增强），后者可能引起发育缺陷。与疾病关联方面，YES1过表达常见于乳腺癌、头颈癌等恶性肿瘤，通过激活PI3K-AKT和STAT3通路促进存活和转移；而敲低YES1可抑制肿瘤生长但可能影响正常组织修复。基因家族共性上，SRC家族成员（如SRC、LYN、FYN）均通过调控细胞骨架动力学和生长信号参与癌症，且共享自抑制调节机制。表达异常时，YES1过表达会增强下游ERK和FAK信号，导致异常增殖；低表达则可能削弱细胞迁移能力。需要注意的是，中文文献中"YES1"偶被译为"耶斯1"，但统一使用"YES1"更规范。

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

此基因是山口肉瘤病毒原癌基因的细胞同系物。所编码的蛋白质具有酪氨酸激酶活性和属于src家族蛋白质。该基因位于靠近胸苷酸合成酶基因在染色体18和对应的假基因已在[通过的RefSeq，2008年7月提供]染色体22被发现

OMIM数据库中对YES1基因的介绍     Wikipedia数据库中对YES1基因的介绍

基因序列

基因序列

YES1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

YES1基因的碱基突变：           仅显示部分snp
rs490678       rs492056       rs523762       rs537141       rs541436       rs557308       rs558535       rs564942       rs572600       rs605199       rs642892       rs1060910       rs1060922       rs1061035       rs1274882       rs1274883       rs1275321      

基因表达

基因表达

YES1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ATTTGGAGGATCCTCAGGG
59
TAACACCACCTGTTAAACCAG
58
AATCCCTCGAGAATCTTTGC
58
CCATTCCATGTTCCCATCC
58
GACATTTCGAGGCTAAAGCA
59
TGCAGCCCATTATCAAATCTG
59
AATCCCTCGAGAATCTTTGC
58
CCATTCCATGTTCCCATCC
58
CCCAGCTAATTTGATAATGGGC
60
TTGTACTGACAGGCTCTGG
59
AATCCCTCGAGAATCTTTGC
58
CCATTCCATGTTCCCATCC
58
TTTGGAGGTGCATCTTCCT
59
CCACAAATATAGTAACACCACCTG
60
CTGCTCAGATTGCTGATGG
59
CAAGAATATTAGCAGCCCGA
58
ACCCAGCTAATTTGATAATGGG
59
GTACTGACAGGCTCTGGAG
59
CTGCTCAGATTGCTGATGG
59
CAAGAATATTAGCAGCCCGA
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
NANOG
YES1
Activation
22378194

基因本体信息

YES1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

YES1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004715
J3QRU1 (UniProtKB)
IEA
GO:0005524
J3QRU1 (UniProtKB)
IEA
GO:0005737
J3QRU1 (UniProtKB)
IDA
GO:0005886
J3QRU1 (UniProtKB)
IDA
GO:0018108
J3QRU1 (UniProtKB)
IEA
GO:0018108
J3QRU1 (UniProtKB)
IEA
GO:0045087
J3QRU1 (UniProtKB)
IEA
GO:0004713
P07947 (UniProtKB)
EXP
GO:0004713
P07947 (UniProtKB)
EXP
GO:0004713
P07947 (UniProtKB)
EXP
GO:0004713
P07947 (UniProtKB)
EXP
GO:0004713
P07947 (UniProtKB)
EXP
GO:0004713
P07947 (UniProtKB)
EXP
GO:0004713
P07947 (UniProtKB)
EXP
GO:0004713
P07947 (UniProtKB)
TAS
GO:0004713
P07947 (UniProtKB)
TAS
GO:0004713
P07947 (UniProtKB)
TAS
GO:0004713
P07947 (UniProtKB)
TAS
GO:0004715
P07947 (UniProtKB)
TAS
GO:0005102
P07947 (UniProtKB)
IBA
GO:0005154
P07947 (UniProtKB)
IEA
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005515
P07947 (UniProtKB)
IPI
GO:0005524
P07947 (UniProtKB)
IEA
GO:0005737
P07947 (UniProtKB)
IDA
GO:0005794
P07947 (UniProtKB)
IDA
GO:0005815
P07947 (UniProtKB)
IEA
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005829
P07947 (UniProtKB)
TAS
GO:0005884
P07947 (UniProtKB)
IEA
GO:0005886
P07947 (UniProtKB)
IDA
GO:0005886
P07947 (UniProtKB)
IDA
GO:0005925
P07947 (UniProtKB)
IDA
GO:0006464
P07947 (UniProtKB)
TAS
GO:0007169
P07947 (UniProtKB)
IBA
GO:0015758
P07947 (UniProtKB)
IEA
GO:0019899
P07947 (UniProtKB)
IPI
GO:0030154
P07947 (UniProtKB)
IBA
GO:0031234
P07947 (UniProtKB)
IBA
GO:0031295
P07947 (UniProtKB)
TAS
GO:0031295
P07947 (UniProtKB)
TAS
GO:0036120
P07947 (UniProtKB)
IEA
GO:0038083
P07947 (UniProtKB)
IBA
GO:0038096
P07947 (UniProtKB)
TAS
GO:0042127
P07947 (UniProtKB)
IBA
GO:0043114
P07947 (UniProtKB)
TAS
GO:0044325
P07947 (UniProtKB)
IPI
GO:0045087
P07947 (UniProtKB)
IBA
GO:0045944
P07947 (UniProtKB)
IEA
GO:0048013
P07947 (UniProtKB)
TAS
GO:0050731
P07947 (UniProtKB)
IEA
GO:0050900
P07947 (UniProtKB)
TAS
GO:0070062
P07947 (UniProtKB)
IDA
GO:0070062
P07947 (UniProtKB)
IDA
GO:0071300
P07947 (UniProtKB)
IEA
GO:0071560
P07947 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 YES1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
IGA Glomerulonephritis 0.12 1 0 CTD_human
Neoplasm Metastasis 0.005720142 2 0 BeFree_LHGDN
Glioblastoma 0.00272435 1 0 LHGDN
Mammary Neoplasms 0.00272435 1 0 LHGDN
Stomach Neoplasms 0.00272435 1 0 LHGDN
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Liver carcinoma 0.00272435 1 0 LHGDN
HIV Infections 0.002367032 1 0 GAD
Malignant neoplasm of stomach 0.000542884 2 0 BeFree
Stomach Carcinoma 0.000542884 2 0 BeFree

基因相关服务

基因相关服务

联系方式

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