YAP1 (Yes1 associated transcriptional regulator)

基因基本信息

基因基本信息

symbol:
YAP1
locus group:
protein-coding gene
location:
11q22.1
gene_family:
alias symbol:
YAP65|YAP-1
alias name:
None
entrez id:
10413
ensembl gene id:
ENSG00000137693
ucsc gene id:
uc001pgt.3
refseq accession:
NM_006106
hgnc_id:
HGNC:16262
approved reserved:
2001-07-17

基因染色体位置

基因染色体位置

11q22.1
基因染色体位置图

基因简述

基因简述

This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]

这个基因编码其参与发育，生长，??修复和稳态河马信号传导途径的下游效应器核。已知该基因发挥其作为这个信号传导途径的转录调节在多种癌症的发展和进展中的作用，并且可以作为用于癌症治疗的潜在靶标发挥作用。在多个转录剪接变异体导致编码不同亚型。 [由RefSeq的，2013年8月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

YAP1基因的碱基突变：           仅显示部分snp
rs8504       rs15067       rs25450       rs948736       rs948737       rs974830       rs983112       rs1365328       rs1365329       rs1365330       rs1365331       rs1426392       rs1426393       rs1426394       rs1426395       rs1426396       rs1426397      

基因表达

基因表达

YAP1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAGATGGAGAAGGAGAGGC
59
ATTGATATTCCGCATTGCCTG
60
CAGATGGAGAAGGAGAGGC
59
ATTGATATTCCGCATTGCCTG
60
CAGATGGAGAAGGAGAGGC
59
ATTGATATTCCGCATTGCCTG
60
TGTCCCAGATGAACGTCAC
60
CCATCAGGAAGAGGACCTG
59
TAGTGCAGACCTGTCTCCT
60
TGATAGGTGCCATTGTCCC
60
AAAGACATCTTCTGGTCAGAG
58
ATTCTCTGGTTCATGGCTG
58
TGTCCCAGATGAACGTCAC
60
CCATCAGGAAGAGGACCTG
59
ATCAGTCAGAGTGCTCCAG
59
GATATTCCGCATTGCCTGC
60
TGTCCCAGATGAACGTCAC
60
CCATCAGGAAGAGGACCTG
59
ATGAGCAGCTACAGTGTCC
60
TGGTTGATAGTATCACCTGTATCC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

YAP1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

YAP1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000902
P46937 (UniProtKB)
IEA
GO:0000979
P46937 (UniProtKB)
IEA
GO:0001076
P46937 (UniProtKB)
IEA
GO:0001570
P46937 (UniProtKB)
IEA
GO:0003143
P46937 (UniProtKB)
IEA
GO:0003682
P46937 (UniProtKB)
IEA
GO:0003713
P46937 (UniProtKB)
IDA
GO:0003713
P46937 (UniProtKB)
IDA
GO:0003714
P46937 (UniProtKB)
IDA
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005515
P46937 (UniProtKB)
IPI
GO:0005634
P46937 (UniProtKB)
IDA
GO:0005634
P46937 (UniProtKB)
IDA
GO:0005634
P46937 (UniProtKB)
IDA
GO:0005654
P46937 (UniProtKB)
TAS
GO:0005654
P46937 (UniProtKB)
TAS
GO:0005654
P46937 (UniProtKB)
TAS
GO:0005654
P46937 (UniProtKB)
TAS
GO:0005667
P46937 (UniProtKB)
IEA
GO:0005737
P46937 (UniProtKB)
IDA
GO:0005737
P46937 (UniProtKB)
IDA
GO:0005829
P46937 (UniProtKB)
TAS
GO:0005829
P46937 (UniProtKB)
TAS
GO:0005829
P46937 (UniProtKB)
TAS
GO:0005829
P46937 (UniProtKB)
TAS
GO:0005829
P46937 (UniProtKB)
TAS
GO:0005829
P46937 (UniProtKB)
TAS
GO:0005829
P46937 (UniProtKB)
TAS
GO:0005829
P46937 (UniProtKB)
TAS
GO:0005829
P46937 (UniProtKB)
TAS
GO:0006367
P46937 (UniProtKB)
TAS
GO:0006974
P46937 (UniProtKB)
IDA
GO:0008022
P46937 (UniProtKB)
IEA
GO:0008283
P46937 (UniProtKB)
IDA
GO:0008284
P46937 (UniProtKB)
IEA
GO:0010837
P46937 (UniProtKB)
IEA
GO:0016020
P46937 (UniProtKB)
IEA
GO:0030216
P46937 (UniProtKB)
IEA
GO:0030857
P46937 (UniProtKB)
IEA
GO:0030903
P46937 (UniProtKB)
IEA
GO:0035019
P46937 (UniProtKB)
IEA
GO:0035329
P46937 (UniProtKB)
TAS
GO:0035329
P46937 (UniProtKB)
TAS
GO:0044212
P46937 (UniProtKB)
IDA
GO:0045944
P46937 (UniProtKB)
IEA
GO:0046622
P46937 (UniProtKB)
IEA
GO:0048339
P46937 (UniProtKB)
IEA
GO:0048368
P46937 (UniProtKB)
IEA
GO:0050767
P46937 (UniProtKB)
IDA
GO:0060242
P46937 (UniProtKB)
IDA
GO:0060449
P46937 (UniProtKB)
IEA
GO:0060487
P46937 (UniProtKB)
IEA
GO:0070064
P46937 (UniProtKB)
IEA
GO:0071300
P46937 (UniProtKB)
IEA
GO:0071480
P46937 (UniProtKB)
IDA
GO:0072091
P46937 (UniProtKB)
IDA
GO:0072307
P46937 (UniProtKB)
IEA
GO:0090263
P46937 (UniProtKB)
IEA
GO:1902459
P46937 (UniProtKB)
IEA
GO:1903507
P46937 (UniProtKB)
IEA
GO:2000737
P46937 (UniProtKB)
IEA
GO:2001237
P46937 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 YAP1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Congenital ocular coloboma (disorder) 0.120542884 2 1 BeFree_CLINVAR
Squamous cell carcinoma of the head and neck 0.120271442 2 0 BeFree_CTD_human
Polycystic Ovary Syndrome 0.120271442 2 1 BeFree_GWASCAT
Epithelioid hemangioendothelioma 0.120271442 1 0 BeFree_ORPHANET
Neuroblastoma 0.12 1 0 CTD_human
Coloboma, Uveal, with Cleft Lip and Palate and Mental Retardation 0.12 0 1 CLINVAR
ovarian neoplasm 0.12 1 0 CTD_human
Coloboma, cleft lip/palate and mental retardation syndrome 0.12 0 0 ORPHANET
Carcinogenesis 0.006514605 24 0 BeFree
Malignant neoplasm of lung 0.003452799 5 0 BeFree_GAD

基因相关服务

基因相关服务

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