XAGE3 (X antigen family member 3)
- symbol:
- XAGE3
- locus group:
- protein-coding gene
- location:
- Xp11.22
- gene_family:
- alias symbol:
- XAGE-3|pp9012|CT12.3a|CT12.3b
- alias name:
- cancer/testis antigen family 12, m…
- entrez id:
- 170626
- ensembl gene id:
- ENSG00000171402
- ucsc gene id:
- uc004drf.4
- refseq accession:
- NM_133179
- hgnc_id:
- HGNC:14618
- approved reserved:
- 2002-04-03
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
该基因是XAGE亚科，属于GAGE家族的一员。的GAGE基因在多种肿瘤，并在一些胎儿和生殖组织中表达。该基因在胎盘和胎儿肝/脾中表达，并抑制癌细胞的生长可能起作用。由该基因编码的蛋白质共享与其他GAGE / PAGE的蛋白质的序列相似性。因为表达模式和序列相似性，这种蛋白也属于一个家族的CT（癌 - 睾丸）抗原。这个基因的可变剪接产生2转录变体的5‘端非编码区不同。 [由RefSeq的，2008年7月提供]
基因本体信息
XAGE3基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
XAGE3基因的本体（GO）信息：
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