WNT5A (Wnt family member 5A)

基因基本信息

基因基本信息

symbol:
WNT5A
locus group:
protein-coding gene
location:
3p14.3
gene_family:
Wingless-type MMTV integration site family|Endogenous ligands
alias symbol:
hWNT5A
alias name:
WNT-5A protein
entrez id:
7474
ensembl gene id:
ENSG00000114251
ucsc gene id:
uc062ktw.1
refseq accession:
NM_003392
hgnc_id:
HGNC:12784
approved reserved:
1993-07-06

基因染色体位置

基因染色体位置

3p14.3
基因染色体位置图

基因简述

基因简述

WNT5A是WNT基因家族的重要成员，该家族编码一组分泌型糖蛋白，通过调控细胞间信号传导参与胚胎发育、细胞增殖和分化等过程。WNT5A属于非经典WNT通路（即不依赖β-catenin的途径），主要通过激活平面细胞极性（PCP）通路和钙离子通路发挥作用，影响细胞迁移、组织极化和器官形成。其表达产物WNT5A蛋白通过与卷曲受体（Frizzled）和辅助受体（如ROR2）结合触发下游信号。WNT5A在多种组织中表达，尤其在神经系统、骨骼和心血管系统发育中起关键作用。突变可能导致功能丧失或异常激活，例如ROR2共受体突变与短指-并指综合征（Robinow综合征）相关，而WNT5A过表达与多种癌症（如黑色素瘤、乳腺癌）的侵袭转移相关。该基因低表达可能引起发育缺陷，如骨骼畸形；而过表达会促进上皮-间质转化（EMT），加速肿瘤转移。WNT家族共性为均含保守的半胱氨酸残基，通过自分泌/旁分泌方式调控进化保守的信号网络。目前WNT5A在组织再生和癌症治疗中的双向作用（既促进修复又驱动肿瘤）是研究热点，其翻译后修饰（如棕榈酰化）对分泌和功能的影响也被重点关注。术语解释：上皮-间质转化（EMT）指上皮细胞获得迁移能力的生物学过程；棕榈酰化（palmitoylation）是蛋白质添加脂质修饰的化学变化。

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Wnt信号基因家族由结构相关基因，其编码分泌信号蛋白。这些蛋白质有牵连肿瘤发生并在几个发育过程，包括胚胎发育过程中细胞命运和图案化的调节。该基因编码的WNT家族通过两者的规范和非经典Wnt途径信号的一个成员。这种蛋白是七跨膜受体型卷曲5和酪氨酸激酶孤儿受体的配体2.本蛋白质起着在胚胎发育过程中调节发育途径至关重要的作用。这种蛋白也可能在肿瘤发生中发挥作用。在这个基因的突变是常染色体显性遗传Robinow综合征的病因。选择性剪接结果在多个抄本变形。 [由RefSeq的，2012年1月提供]

OMIM数据库中对WNT5A基因的介绍     Wikipedia数据库中对WNT5A基因的介绍

基因序列

基因序列

WNT5A基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

WNT5A基因的碱基突变：           仅显示部分snp
rs472631       rs484247       rs502912       rs504849       rs506611       rs519730       rs524153       rs556874       rs557077       rs566926       rs589557       rs590386       rs620014       rs623456       rs639000       rs648872       rs652594      

基因表达

基因表达

WNT5A基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTGCAGAACAGGAAATAGCAC
60
TAGAGGATCCTATTCTGCTTCTC
59
GAAGTCCATTGGAATATTAAGCCC
60
TTATTCATACCTAGCGACCACC
60
GTTCTTCCTAGTGGCTTTGG
59
TTCATACCTAGCGACCACC
59
GTTCTTCCTAGTGGCTTTGG
59
TTCATACCTAGCGACCACC
59
GTTCTTCCTAGTGGCTTTGG
58
TTCATACCTAGCGACCACC
58
GTTCTTCCTAGTGGCTTTGG
59
TTCATACCTAGCGACCACC
59
GAAGTCCATTGGAATATTAAGCCC
60
TTATTCATACCTAGCGACCACC
60
CTGTTCAGATGTCAGAAGACG
59
CTTGAACTGGTCGTAGCCA
60
TACCATCTAAGAACTCTGTGGT
58
CAGAAAGCAAGCTAGCAGC
60
GTTCAGATGTCAGAAGACGT
58
GTCTTGAACTGGTCGTAGC
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
CUX1
WNT5A
Activation
17227781; 23359789
HOXB7
WNT5A
Activation
21183939
PITX2
WNT5A
Unknown
23250740

基因本体信息

WNT5A基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

WNT5A基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005102
A0A087WUN1 (UniProtKB)
IEA
GO:0005576
A0A087WUN1 (UniProtKB)
IEA
GO:0007275
A0A087WUN1 (UniProtKB)
IEA
GO:0016021
A0A087WUN1 (UniProtKB)
IEA
GO:0016055
A0A087WUN1 (UniProtKB)
IEA
GO:0005102
C9J8I8 (UniProtKB)
IEA
GO:0005578
C9J8I8 (UniProtKB)
IEA
GO:0007275
C9J8I8 (UniProtKB)
IEA
GO:0016055
C9J8I8 (UniProtKB)
IEA
GO:0000187
P41221 (UniProtKB)
IDA
GO:0001736
P41221 (UniProtKB)
IEA
GO:0001756
P41221 (UniProtKB)
IEA
GO:0001837
P41221 (UniProtKB)
IEP
GO:0001938
P41221 (UniProtKB)
IMP
GO:0001947
P41221 (UniProtKB)
IEA
GO:0002053
P41221 (UniProtKB)
IEA
GO:0002088
P41221 (UniProtKB)
ISS
GO:0002741
P41221 (UniProtKB)
IMP
GO:0003323
P41221 (UniProtKB)
IEA
GO:0003402
P41221 (UniProtKB)
IEA
GO:0003408
P41221 (UniProtKB)
ISS
GO:0003700
P41221 (UniProtKB)
IMP
GO:0005109
P41221 (UniProtKB)
IPI
GO:0005110
P41221 (UniProtKB)
IEA
GO:0005115
P41221 (UniProtKB)
IPI
GO:0005125
P41221 (UniProtKB)
IEA
GO:0005515
P41221 (UniProtKB)
IPI
GO:0005576
P41221 (UniProtKB)
TAS
GO:0005576
P41221 (UniProtKB)
TAS
GO:0005576
P41221 (UniProtKB)
TAS
GO:0005576
P41221 (UniProtKB)
TAS
GO:0005576
P41221 (UniProtKB)
TAS
GO:0005576
P41221 (UniProtKB)
TAS
GO:0005578
P41221 (UniProtKB)
IEA
GO:0005615
P41221 (UniProtKB)
IDA
GO:0005615
P41221 (UniProtKB)
IDA
GO:0005615
P41221 (UniProtKB)
IDA
GO:0005788
P41221 (UniProtKB)
TAS
GO:0005796
P41221 (UniProtKB)
TAS
GO:0005796
P41221 (UniProtKB)
TAS
GO:0005796
P41221 (UniProtKB)
TAS
GO:0005886
P41221 (UniProtKB)
TAS
GO:0005886
P41221 (UniProtKB)
TAS
GO:0005886
P41221 (UniProtKB)
TAS
GO:0007223
P41221 (UniProtKB)
IMP
GO:0007223
P41221 (UniProtKB)
IDA
GO:0007223
P41221 (UniProtKB)
NAS
GO:0007257
P41221 (UniProtKB)
IMP
GO:0007257
P41221 (UniProtKB)
IDA
GO:0007411
P41221 (UniProtKB)
ISS
GO:0007416
P41221 (UniProtKB)
TAS
GO:0007442
P41221 (UniProtKB)
IEA
GO:0007494
P41221 (UniProtKB)
IEA
GO:0008584
P41221 (UniProtKB)
IEP
GO:0008595
P41221 (UniProtKB)
IEA
GO:0009986
P41221 (UniProtKB)
IEA
GO:0010033
P41221 (UniProtKB)
IEP
GO:0010595
P41221 (UniProtKB)
IMP
GO:0010595
P41221 (UniProtKB)
IMP
GO:0010800
P41221 (UniProtKB)
IEA
GO:0010820
P41221 (UniProtKB)
IMP
GO:0010976
P41221 (UniProtKB)
ISS
GO:0016055
P41221 (UniProtKB)
IDA
GO:0016055
P41221 (UniProtKB)
TAS
GO:0019904
P41221 (UniProtKB)
IEA
GO:0021891
P41221 (UniProtKB)
ISS
GO:0030182
P41221 (UniProtKB)
ISS
GO:0030216
P41221 (UniProtKB)
IEP
GO:0030514
P41221 (UniProtKB)
IEA
GO:0030666
P41221 (UniProtKB)
TAS
GO:0030666
P41221 (UniProtKB)
TAS
GO:0030669
P41221 (UniProtKB)
TAS
GO:0030669
P41221 (UniProtKB)
TAS
GO:0030825
P41221 (UniProtKB)
IDA
GO:0030850
P41221 (UniProtKB)
IEA
GO:0032092
P41221 (UniProtKB)
IEA
GO:0032148
P41221 (UniProtKB)
IDA
GO:0032355
P41221 (UniProtKB)
IEA
GO:0032729
P41221 (UniProtKB)
IEA
GO:0032755
P41221 (UniProtKB)
IMP
GO:0033138
P41221 (UniProtKB)
IEA
GO:0033574
P41221 (UniProtKB)
IEA
GO:0034613
P41221 (UniProtKB)
IDA
GO:0035567
P41221 (UniProtKB)
TAS
GO:0036342
P41221 (UniProtKB)
IEA
GO:0036517
P41221 (UniProtKB)
IEA
GO:0036518
P41221 (UniProtKB)
IEA
GO:0038031
P41221 (UniProtKB)
IEA
GO:0040037
P41221 (UniProtKB)
IEA
GO:0042060
P41221 (UniProtKB)
IDA
GO:0042733
P41221 (UniProtKB)
IEA
GO:0043032
P41221 (UniProtKB)
IMP
GO:0043066
P41221 (UniProtKB)
IDA
GO:0044212
P41221 (UniProtKB)
IDA
GO:0044849
P41221 (UniProtKB)
IEA
GO:0045080
P41221 (UniProtKB)
IMP
GO:0045165
P41221 (UniProtKB)
IBA
GO:0045198
P41221 (UniProtKB)
IEA
GO:0045599
P41221 (UniProtKB)
IMP
GO:0045732
P41221 (UniProtKB)
IGI
GO:0045732
P41221 (UniProtKB)
IGI
GO:0045766
P41221 (UniProtKB)
IMP
GO:0045778
P41221 (UniProtKB)
IMP
GO:0045807
P41221 (UniProtKB)
IEA
GO:0045836
P41221 (UniProtKB)
IEA
GO:0045892
P41221 (UniProtKB)
IDA
GO:0045893
P41221 (UniProtKB)
IMP
GO:0045944
P41221 (UniProtKB)
IMP
GO:0048018
P41221 (UniProtKB)
IC
GO:0048022
P41221 (UniProtKB)
IEA
GO:0048146
P41221 (UniProtKB)
IDA
GO:0048286
P41221 (UniProtKB)
IEA
GO:0048341
P41221 (UniProtKB)
IEA
GO:0048570
P41221 (UniProtKB)
IEA
GO:0048706
P41221 (UniProtKB)
IMP
GO:0048806
P41221 (UniProtKB)
IMP
GO:0048843
P41221 (UniProtKB)
IEA
GO:0048850
P41221 (UniProtKB)
IEA
GO:0050680
P41221 (UniProtKB)
IEA
GO:0050718
P41221 (UniProtKB)
IMP
GO:0050729
P41221 (UniProtKB)
IMP
GO:0051092
P41221 (UniProtKB)
IDA
GO:0051216
P41221 (UniProtKB)
IEA
GO:0051384
P41221 (UniProtKB)
IEA
GO:0051964
P41221 (UniProtKB)
IEA
GO:0055093
P41221 (UniProtKB)
IEA
GO:0060021
P41221 (UniProtKB)
IMP
GO:0060028
P41221 (UniProtKB)
IEA
GO:0060029
P41221 (UniProtKB)
IEA
GO:0060065
P41221 (UniProtKB)
IEA
GO:0060067
P41221 (UniProtKB)
IEA
GO:0060068
P41221 (UniProtKB)
IEA
GO:0060070
P41221 (UniProtKB)
IEA
GO:0060071
P41221 (UniProtKB)
TAS
GO:0060071
P41221 (UniProtKB)
TAS
GO:0060157
P41221 (UniProtKB)
IEA
GO:0060324
P41221 (UniProtKB)
IMP
GO:0060340
P41221 (UniProtKB)
IDA
GO:0060599
P41221 (UniProtKB)
IEA
GO:0060638
P41221 (UniProtKB)
IEA
GO:0060686
P41221 (UniProtKB)
IEA
GO:0060744
P41221 (UniProtKB)
IEA
GO:0060750
P41221 (UniProtKB)
IEA
GO:0060760
P41221 (UniProtKB)
IDA
GO:0060762
P41221 (UniProtKB)
IEA
GO:0060775
P41221 (UniProtKB)
IEA
GO:0060809
P41221 (UniProtKB)
IEA
GO:0060907
P41221 (UniProtKB)
IMP
GO:0061036
P41221 (UniProtKB)
IEA
GO:0061347
P41221 (UniProtKB)
IEA
GO:0061348
P41221 (UniProtKB)
IEA
GO:0061349
P41221 (UniProtKB)
IEA
GO:0061350
P41221 (UniProtKB)
IEA
GO:0061354
P41221 (UniProtKB)
IEA
GO:0070062
P41221 (UniProtKB)
TAS
GO:0070062
P41221 (UniProtKB)
TAS
GO:0070062
P41221 (UniProtKB)
TAS
GO:0070062
P41221 (UniProtKB)
TAS
GO:0070062
P41221 (UniProtKB)
TAS
GO:0070062
P41221 (UniProtKB)
TAS
GO:0070245
P41221 (UniProtKB)
IEA
GO:0071222
P41221 (UniProtKB)
IEP
GO:0071277
P41221 (UniProtKB)
IEP
GO:0071300
P41221 (UniProtKB)
ISS
GO:0071346
P41221 (UniProtKB)
IEP
GO:0071425
P41221 (UniProtKB)
IDA
GO:0071560
P41221 (UniProtKB)
IEP
GO:0072201
P41221 (UniProtKB)
IDA
GO:0090009
P41221 (UniProtKB)
IEA
GO:0090037
P41221 (UniProtKB)
IMP
GO:0090090
P41221 (UniProtKB)
IGI
GO:0090090
P41221 (UniProtKB)
IGI
GO:0090090
P41221 (UniProtKB)
IDA
GO:0090103
P41221 (UniProtKB)
IEA
GO:0090179
P41221 (UniProtKB)
IEA
GO:0090630
P41221 (UniProtKB)
IEA
GO:0097325
P41221 (UniProtKB)
IEA
GO:1900020
P41221 (UniProtKB)
IMP
GO:1902379
P41221 (UniProtKB)
IEA
GO:1902474
P41221 (UniProtKB)
TAS
GO:1903827
P41221 (UniProtKB)
IEA
GO:1904861
P41221 (UniProtKB)
TAS
GO:1904862
P41221 (UniProtKB)
TAS
GO:1904934
P41221 (UniProtKB)
NAS
GO:1904953
P41221 (UniProtKB)
NAS
GO:1904955
P41221 (UniProtKB)
TAS
GO:2000049
P41221 (UniProtKB)
IEA
GO:2000052
P41221 (UniProtKB)
IEA
GO:2000484
P41221 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 WNT5A基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Robinow Syndrome 0.241357209 5 4 BeFree_CLINVAR_UNIPROT
Neoplastic Cell Transformation 0.12 1 0 CTD_human
Female Urogenital Diseases 0.12 1 0 CTD_human
Uterine Cervical Neoplasm 0.12 1 0 CTD_human
Lung Neoplasms 0.12 1 0 CTD_human
Anorectal Anomalies 0.08 0 0 MGD
melanoma 0.015511913 19 0 BeFree_LHGDN
Neoplasm Metastasis 0.00706742 17 0 BeFree_LHGDN
Mammary Neoplasms 0.006534468 6 0 BeFree_LHGDN
Prostatic Neoplasms 0.0054487 2 0 LHGDN

基因相关服务

基因相关服务

联系方式

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