WFDC1 (WAP four-disulfide core domain 1)
- symbol:
- WFDC1
- locus group:
- protein-coding gene
- location:
- 16q24.1
- gene_family:
- WAP four-disulfide core domain containing
- alias symbol:
- PS20
- alias name:
- None
- entrez id:
- 58189
- ensembl gene id:
- ENSG00000103175
- ucsc gene id:
- uc002fhw.5
- refseq accession:
- NM_001282466
- hgnc_id:
- HGNC:15466
- approved reserved:
- 2001-03-30
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
该基因编码在WAP型四二硫化物核心域家族的一个成员。在WAP型四二硫化物核心域包含八个半胱氨酸形成在蛋白的核心四二硫键，并且用作在许多家庭成员的蛋白酶抑制剂。该基因被映射到16q24染色体，在癌症的杂合性经常丧失，包括前列腺癌，乳腺癌和肝细胞癌和肾母细胞瘤的区域。该基因在许多癌症类型被下调，并且可以参与细胞增殖的抑制。所编码的蛋白质也可起到一定的CD4记忆T细胞对人类免疫缺陷病毒感染的易感性的作用。选择性剪接结果在多个抄本变形。 [由RefSeq的，2013年9月提供]
基因本体信息
WFDC1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
WFDC1基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| melanoma | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Rheumatoid Arthritis | 0.002367032 | 1 | 0 | GAD |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Influenza | 0.000271442 | 1 | 0 | BeFree |
| Fibrosarcoma | 0.000271442 | 1 | 0 | BeFree |
| HIV Infections | 0.000271442 | 1 | 0 | BeFree |
| Dyspnea | 0.000271442 | 1 | 0 | BeFree |
| Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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