VEGFA (vascular endothelial growth factor A)

基因基本信息

基因基本信息

symbol:
VEGFA
locus group:
protein-coding gene
location:
6p21.1
gene_family:
alias symbol:
VEGF-A|VPF
alias name:
None
entrez id:
7422
ensembl gene id:
ENSG00000112715
ucsc gene id:
uc063oun.1
refseq accession:
NM_001025366
hgnc_id:
HGNC:12680
approved reserved:
1994-01-10

基因染色体位置

基因染色体位置

6p21.1
基因染色体位置图

基因简述

基因简述

VEGFA（血管内皮生长因子A，Vascular Endothelial Growth Factor A）是一种重要的促血管生成因子，属于VEGF基因家族（包括VEGFA、VEGFB、VEGFC、VEGFD等）。该家族成员均为分泌型糖蛋白，通过调控血管内皮细胞增殖、迁移和存活来参与血管生成（angiogenesis，新血管形成）和淋巴管生成（lymphangiogenesis）。VEGFA主要通过与细胞膜上的受体（如VEGFR1、VEGFR2）结合发挥作用，其中VEGFR2是介导其促血管生成功能的主要受体。VEGFA的表达受缺氧（通过HIF-1α调控）、生长因子和炎症因子等刺激诱导。其生物学功能包括促进血管通透性增加、内皮细胞存活和血管网络形成，在胚胎发育、伤口愈合和女性生殖周期中起关键作用。VEGFA突变或表达异常与多种疾病相关：过表达可能导致病理性血管增生，如肿瘤（通过提供营养支持促进癌症生长和转移）、糖尿病视网膜病变和银屑病；而表达不足则可能引发缺血性疾病（如心肌梗死）或子痫前期（胎盘血管发育异常）。VEGFA基因存在多个剪接变体（如VEGF121、VEGF165等），不同亚型具有差异性的受体结合能力和生物活性。在肿瘤治疗中，抗VEGF药物（如贝伐珠单抗）被用于抑制血管生成。该基因家族成员的共性是均含有特征性的半胱氨酸结（cysteine knot）结构域，并能特异性结合VEGFR受体。VEGFA表达水平变化会影响其他血管相关基因（如ANGPT2、PDGFB）的表达，形成血管调控网络。在基因治疗中，VEGFA被尝试用于促进缺血组织的侧支循环形成，但需精确控制剂量以避免异常血管增生。

None

无

OMIM数据库中对VEGFA基因的介绍     Wikipedia数据库中对VEGFA基因的介绍

基因序列

基因序列

VEGFA基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

VEGFA基因的碱基突变：           仅显示部分snp
rs10434       rs25648       rs699947       rs715843       rs735286       rs833061       rs833062       rs833067       rs833068       rs833069       rs833070       rs865577       rs943070       rs1005230       rs1049160       rs1413711       rs1570360      

基因表达

基因表达

VEGFA基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CATCTTCAAGCCATCCTGTG
59
TTTACACGTCTGCATGGTG
59
AAGAAATCCCGTCCCTGTG
60
GTTTAACTCAAGCTGCCTCG
60
ACAAATGTGAATGCAGACCA
58
AAATGCTTTCTCCGCTCTG
59
TATGCGGATCAAACCTCAC
58
CTTTCTTTGGTCTGCATTCAC
58
TATGCGGATCAAACCTCAC
58
CTTTCTTTGGTCTGCATTCAC
58
AGACGTGTAAATGTTCCTGC
59
TTGTCACATCTGCAAGTACG
59
ACCATGCAGATTATGCGGA
60
TTCACATTTGTTGTGCTGTAGG
60
AGACGTGTAAATGTTCCTGC
59
TTGTCACATCTGCAAGTACG
59
ATAAGTCCTGGAGCGTTCC
59
CTTGTCACATCTGCAAGTACG
60
ACAAATGTGAATGCAGACCA
58
CCATGGAGAGGGAGAAGTG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
AR
VEGFA
Activation
16007189
AR
VEGFA
Unknown
23369005
ARNT
VEGFA
Unknown
16774940; 19020709
ATF4
VEGFA
Activation
15788408; 18829529
ATF4
VEGFA
Unknown
18451308; 22915762; 23908598
ATM
VEGFA
Repression
20676049
BRCA1
VEGFA
Activation
16543242
COPS5
VEGFA
Activation
12542982
DNMT1
VEGFA
Activation
17934516
E2F1
VEGFA
Repression
20639906

基因本体信息

VEGFA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

VEGFA基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0008083
A0A087WTP4 (UniProtKB)
IEA
GO:0016020
A0A087WTP4 (UniProtKB)
IEA
GO:0008083
A0A087X1L1 (UniProtKB)
IEA
GO:0016020
A0A087X1L1 (UniProtKB)
IEA
GO:0008083
A0A0A0MSH5 (UniProtKB)
IEA
GO:0008201
A0A0A0MSH5 (UniProtKB)
IEA
GO:0016020
A0A0A0MSH5 (UniProtKB)
IEA
GO:0008083
A0A0A0MSH7 (UniProtKB)
IEA
GO:0008201
A0A0A0MSH7 (UniProtKB)
IEA
GO:0016020
A0A0A0MSH7 (UniProtKB)
IEA
GO:0008083
A0A0A0MSI7 (UniProtKB)
IEA
GO:0008201
A0A0A0MSI7 (UniProtKB)
IEA
GO:0016020
A0A0A0MSI7 (UniProtKB)
IEA
GO:0008083
A0A0A0MTB2 (UniProtKB)
IEA
GO:0008201
A0A0A0MTB2 (UniProtKB)
IEA
GO:0016020
A0A0A0MTB2 (UniProtKB)
IEA
GO:0008083
A2A2V4 (UniProtKB)
IEA
GO:0008201
A2A2V4 (UniProtKB)
IEA
GO:0016020
A2A2V4 (UniProtKB)
IEA
GO:0008083
H0YBI8 (UniProtKB)
IEA
GO:0008201
H0YBI8 (UniProtKB)
IEA
GO:0016020
H0YBI8 (UniProtKB)
IEA
GO:0008083
H0YBZ0 (UniProtKB)
IEA
GO:0016020
H0YBZ0 (UniProtKB)
IEA
GO:0008083
H3BLW8 (UniProtKB)
IEA
GO:0008201
H3BLW8 (UniProtKB)
IEA
GO:0016020
H3BLW8 (UniProtKB)
IEA
GO:0008083
J3KPA4 (UniProtKB)
IEA
GO:0008201
J3KPA4 (UniProtKB)
IEA
GO:0016020
J3KPA4 (UniProtKB)
IEA
GO:0000122
P15692 (UniProtKB)
IDA
GO:0001525
P15692 (UniProtKB)
IDA
GO:0001525
P15692 (UniProtKB)
IDA
GO:0001541
P15692 (UniProtKB)
ISS
GO:0001569
P15692 (UniProtKB)
ISS
GO:0001570
P15692 (UniProtKB)
TAS
GO:0001666
P15692 (UniProtKB)
IDA
GO:0001701
P15692 (UniProtKB)
ISS
GO:0001822
P15692 (UniProtKB)
ISS
GO:0001934
P15692 (UniProtKB)
IDA
GO:0001934
P15692 (UniProtKB)
IDA
GO:0001938
P15692 (UniProtKB)
ISS
GO:0001938
P15692 (UniProtKB)
IDA
GO:0001938
P15692 (UniProtKB)
IDA
GO:0001938
P15692 (UniProtKB)
IDA
GO:0001938
P15692 (UniProtKB)
IDA
GO:0001938
P15692 (UniProtKB)
IDA
GO:0001938
P15692 (UniProtKB)
IDA
GO:0001938
P15692 (UniProtKB)
IDA
GO:0001968
P15692 (UniProtKB)
IDA
GO:0002042
P15692 (UniProtKB)
IDA
GO:0002042
P15692 (UniProtKB)
IDA
GO:0002052
P15692 (UniProtKB)
ISS
GO:0002053
P15692 (UniProtKB)
ISS
GO:0002092
P15692 (UniProtKB)
IDA
GO:0002575
P15692 (UniProtKB)
IDA
GO:0002576
P15692 (UniProtKB)
TAS
GO:0002687
P15692 (UniProtKB)
TAS
GO:0003007
P15692 (UniProtKB)
ISS
GO:0003151
P15692 (UniProtKB)
ISS
GO:0003169
P15692 (UniProtKB)
ISS
GO:0005125
P15692 (UniProtKB)
ISS
GO:0005125
P15692 (UniProtKB)
IDA
GO:0005161
P15692 (UniProtKB)
IPI
GO:0005161
P15692 (UniProtKB)
IPI
GO:0005172
P15692 (UniProtKB)
IPI
GO:0005172
P15692 (UniProtKB)
IPI
GO:0005172
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005515
P15692 (UniProtKB)
IPI
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005576
P15692 (UniProtKB)
TAS
GO:0005578
P15692 (UniProtKB)
NAS
GO:0005615
P15692 (UniProtKB)
ISS
GO:0005615
P15692 (UniProtKB)
IDA
GO:0005615
P15692 (UniProtKB)
IDA
GO:0005737
P15692 (UniProtKB)
IDA
GO:0006357
P15692 (UniProtKB)
IMP
GO:0007399
P15692 (UniProtKB)
TAS
GO:0007498
P15692 (UniProtKB)
ISS
GO:0007595
P15692 (UniProtKB)
ISS
GO:0008083
P15692 (UniProtKB)
ISS
GO:0008083
P15692 (UniProtKB)
IDA
GO:0008083
P15692 (UniProtKB)
IDA
GO:0008201
P15692 (UniProtKB)
IMP
GO:0008201
P15692 (UniProtKB)
IDA
GO:0008284
P15692 (UniProtKB)
IDA
GO:0008360
P15692 (UniProtKB)
IDA
GO:0008360
P15692 (UniProtKB)
IDA
GO:0009986
P15692 (UniProtKB)
IDA
GO:0010595
P15692 (UniProtKB)
IDA
GO:0010595
P15692 (UniProtKB)
IDA
GO:0010628
P15692 (UniProtKB)
IDA
GO:0016020
P15692 (UniProtKB)
IEA
GO:0030141
P15692 (UniProtKB)
IDA
GO:0030224
P15692 (UniProtKB)
IDA
GO:0030225
P15692 (UniProtKB)
IDA
GO:0030324
P15692 (UniProtKB)
ISS
GO:0030335
P15692 (UniProtKB)
IDA
GO:0030335
P15692 (UniProtKB)
IDA
GO:0030823
P15692 (UniProtKB)
IDA
GO:0030855
P15692 (UniProtKB)
ISS
GO:0030949
P15692 (UniProtKB)
IDA
GO:0030949
P15692 (UniProtKB)
IDA
GO:0031077
P15692 (UniProtKB)
ISS
GO:0031093
P15692 (UniProtKB)
TAS
GO:0031334
P15692 (UniProtKB)
IDA
GO:0031334
P15692 (UniProtKB)
IDA
GO:0031954
P15692 (UniProtKB)
IDA
GO:0031954
P15692 (UniProtKB)
IDA
GO:0032147
P15692 (UniProtKB)
IDA
GO:0032147
P15692 (UniProtKB)
IDA
GO:0032793
P15692 (UniProtKB)
IDA
GO:0033138
P15692 (UniProtKB)
IDA
GO:0033138
P15692 (UniProtKB)
IDA
GO:0035148
P15692 (UniProtKB)
IDA
GO:0035767
P15692 (UniProtKB)
IDA
GO:0035924
P15692 (UniProtKB)
IDA
GO:0035924
P15692 (UniProtKB)
IDA
GO:0036303
P15692 (UniProtKB)
ISS
GO:0038033
P15692 (UniProtKB)
IDA
GO:0038033
P15692 (UniProtKB)
IDA
GO:0038033
P15692 (UniProtKB)
IDA
GO:0038084
P15692 (UniProtKB)
IDA
GO:0038091
P15692 (UniProtKB)
IDA
GO:0038091
P15692 (UniProtKB)
IDA
GO:0038091
P15692 (UniProtKB)
IDA
GO:0038190
P15692 (UniProtKB)
ISS
GO:0038191
P15692 (UniProtKB)
IPI
GO:0038191
P15692 (UniProtKB)
IPI
GO:0040007
P15692 (UniProtKB)
ISS
GO:0042056
P15692 (UniProtKB)
IDA
GO:0042056
P15692 (UniProtKB)
IDA
GO:0042056
P15692 (UniProtKB)
IDA
GO:0042056
P15692 (UniProtKB)
IDA
GO:0042056
P15692 (UniProtKB)
IDA
GO:0042056
P15692 (UniProtKB)
IDA
GO:0042462
P15692 (UniProtKB)
ISS
GO:0042802
P15692 (UniProtKB)
IPI
GO:0042802
P15692 (UniProtKB)
IPI
GO:0042802
P15692 (UniProtKB)
IPI
GO:0042802
P15692 (UniProtKB)
IPI
GO:0042803
P15692 (UniProtKB)
ISS
GO:0043066
P15692 (UniProtKB)
IMP
GO:0043066
P15692 (UniProtKB)
IMP
GO:0043117
P15692 (UniProtKB)
IDA
GO:0043129
P15692 (UniProtKB)
ISS
GO:0043154
P15692 (UniProtKB)
IDA
GO:0043183
P15692 (UniProtKB)
IPI
GO:0043184
P15692 (UniProtKB)
IPI
GO:0043184
P15692 (UniProtKB)
IPI
GO:0043184
P15692 (UniProtKB)
IPI
GO:0043406
P15692 (UniProtKB)
IDA
GO:0043536
P15692 (UniProtKB)
IDA
GO:0043536
P15692 (UniProtKB)
IDA
GO:0043536
P15692 (UniProtKB)
IDA
GO:0045766
P15692 (UniProtKB)
IMP
GO:0045766
P15692 (UniProtKB)
IDA
GO:0045766
P15692 (UniProtKB)
IDA
GO:0045766
P15692 (UniProtKB)
IDA
GO:0045766
P15692 (UniProtKB)
IDA
GO:0045785
P15692 (UniProtKB)
IDA
GO:0045944
P15692 (UniProtKB)
IDA
GO:0045944
P15692 (UniProtKB)
IDA
GO:0045944
P15692 (UniProtKB)
IMP
GO:0046982
P15692 (UniProtKB)
IDA
GO:0048010
P15692 (UniProtKB)
IDA
GO:0048010
P15692 (UniProtKB)
IDA
GO:0048010
P15692 (UniProtKB)
TAS
GO:0048010
P15692 (UniProtKB)
TAS
GO:0048018
P15692 (UniProtKB)
IPI
GO:0048018
P15692 (UniProtKB)
IPI
GO:0048018
P15692 (UniProtKB)
IPI
GO:0048469
P15692 (UniProtKB)
ISS
GO:0048593
P15692 (UniProtKB)
ISS
GO:0048739
P15692 (UniProtKB)
ISS
GO:0048754
P15692 (UniProtKB)
ISS
GO:0048842
P15692 (UniProtKB)
ISS
GO:0048844
P15692 (UniProtKB)
ISS
GO:0050679
P15692 (UniProtKB)
ISS
GO:0050731
P15692 (UniProtKB)
IDA
GO:0050731
P15692 (UniProtKB)
IDA
GO:0050731
P15692 (UniProtKB)
IDA
GO:0050731
P15692 (UniProtKB)
IDA
GO:0050840
P15692 (UniProtKB)
IC
GO:0050918
P15692 (UniProtKB)
IEA
GO:0050918
P15692 (UniProtKB)
IDA
GO:0050927
P15692 (UniProtKB)
IDA
GO:0050927
P15692 (UniProtKB)
IDA
GO:0050930
P15692 (UniProtKB)
NAS
GO:0050930
P15692 (UniProtKB)
IDA
GO:0051272
P15692 (UniProtKB)
IDA
GO:0051272
P15692 (UniProtKB)
IDA
GO:0051781
P15692 (UniProtKB)
IEA
GO:0051894
P15692 (UniProtKB)
IDA
GO:0060319
P15692 (UniProtKB)
ISS
GO:0060749
P15692 (UniProtKB)
ISS
GO:0060754
P15692 (UniProtKB)
IDA
GO:0060948
P15692 (UniProtKB)
ISS
GO:0060982
P15692 (UniProtKB)
ISS
GO:0061418
P15692 (UniProtKB)
TAS
GO:0061419
P15692 (UniProtKB)
IMP
GO:0070374
P15692 (UniProtKB)
IDA
GO:0071456
P15692 (UniProtKB)
IDA
GO:0071542
P15692 (UniProtKB)
ISS
GO:0071679
P15692 (UniProtKB)
ISS
GO:0090037
P15692 (UniProtKB)
IDA
GO:0090050
P15692 (UniProtKB)
IDA
GO:0090190
P15692 (UniProtKB)
ISS
GO:0090259
P15692 (UniProtKB)
ISS
GO:0090259
P15692 (UniProtKB)
ISS
GO:1900086
P15692 (UniProtKB)
IDA
GO:1900745
P15692 (UniProtKB)
IDA
GO:1901727
P15692 (UniProtKB)
IDA
GO:1902336
P15692 (UniProtKB)
ISS
GO:1902966
P15692 (UniProtKB)
IDA
GO:1903572
P15692 (UniProtKB)
IDA
GO:0042517
P15692 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 VEGFA基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neoplasm Metastasis 0.262660056 346 1 BeFree_CTD_human_LHGDN
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 1(finding) 0.24 0 1 CLINVAR_CTD_human
Colonic Neoplasms 0.238611723 20 9 BeFree_CTD_human_GAD_LHGDN_RGD
Diabetic Retinopathy 0.209651522 82 2 BeFree_CTD_human_GAD_LHGDN
Retinal Vein Occlusion 0.20272435 3 0 CTD_human_LHGDN_RGD
Choroidal Neovascularization 0.202367032 3 0 CTD_human_GAD_RGD
Diabetes Mellitus, Experimental 0.2 3 0 CTD_human_RGD
Squamous cell carcinoma 0.191363889 68 0 BeFree_CTD_human_GAD_LHGDN
Age related macular degeneration 0.184936873 81 9 BeFree_CTD_human_GAD_LHGDN
Diabetes Mellitus, Non-Insulin-Dependent 0.18095634 44 24 BeFree_CTD_human_GAD

基因相关服务

基因相关服务

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