UCKL1 (uridine-cytidine kinase 1 like 1)
- symbol:
- UCKL1
- locus group:
- protein-coding gene
- location:
- 20q13.33
- gene_family:
- alias symbol:
- FLJ20517
- alias name:
- None
- entrez id:
- 54963
- ensembl gene id:
- ENSG00000198276
- ucsc gene id:
- uc011abm.3
- refseq accession:
- NM_017859
- hgnc_id:
- HGNC:15938
- approved reserved:
- 2001-06-21
The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
由该基因编码的蛋白质是尿苷激酶。尿苷激酶催化尿苷以尿苷酸磷酸化。这种蛋白已经显示结合爱泼斯坦 - 巴尔核抗原3以及天然杀伤裂解相关分子。这种蛋白质的泛素化是通过自然杀伤裂解相关分子的存在而增强。此外，蛋白水平降低天然杀伤裂解相关分子的存在，这表明在泛素化和这种蛋白质的随后的降解天然杀伤裂解相关分子的结果关联。选择性剪接结果在多个抄本变形。 [由RefSeq的，2014年11月提供]
基因本体信息
UCKL1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
UCKL1基因的本体（GO）信息：
| 名称 |
|---|
| 240 Pyrimidine metabolism [PATH:hsa00240] |
| 983 Drug metabolism - other enzymes [PATH:hsa00983] |
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