UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1)
- symbol:
- UBA52
- locus group:
- protein-coding gene
- location:
- 19p13.1-p12
- gene_family:
- L ribosomal proteins
- alias symbol:
- RPL40|CEP52|HUBCEP52|MGC57125|MGC126879|MGC126881|L40
- alias name:
- ribosomal protein L40|ubiquitin-52…
- entrez id:
- 7311
- ensembl gene id:
- ENSG00000221983
- ucsc gene id:
- uc002njr.4
- refseq accession:
- NM_003333
- hgnc_id:
- HGNC:12458
- approved reserved:
- 1992-07-31
UBA52基因编码一种泛素（ubiquitin）前体蛋白，属于泛素基因家族（ubiquitin gene family）。泛素是一种高度保守的小分子蛋白，广泛存在于真核生物中，主要功能是通过泛素-蛋白酶体系统（ubiquitin-proteasome system, UPS）标记需要降解的蛋白质，参与蛋白质的稳态调控、细胞周期控制、DNA修复和免疫应答等关键生物学过程。UBA52基因与其他泛素基因（如UBA80、RPS27A）类似，其编码的泛素前体蛋白经过蛋白酶切割后释放出成熟的泛素分子。泛素通过共价结合靶蛋白（称为泛素化），形成多泛素链（polyubiquitin chain），从而引导靶蛋白被26S蛋白酶体识别并降解。UBA52基因的突变可能影响泛素的正常功能，导致蛋白质降解异常，进而引发神经退行性疾病（如帕金森病、阿尔茨海默病）、癌症或自身免疫性疾病。若UBA52过表达，可能加速某些蛋白质的异常降解，破坏细胞稳态；而表达降低则可能导致泛素供应不足，影响蛋白质质量控制，诱发错误折叠蛋白的积累。泛素基因家族的共性在于其成员均编码泛素或泛素样蛋白（ubiquitin-like proteins, UBLs），参与翻译后修饰和细胞信号传导。该家族蛋白通常具有高度保守的76个氨基酸核心结构，并通过类似的酶促反应（如E1激活酶、E2结合酶、E3连接酶）发挥作用。目前UBA52的中文译名“泛素A52”较为通用，但需注意其与泛素核糖体融合蛋白（ubiquitin-ribosomal fusion protein）的关联性。
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]
泛素是具有由26S蛋白酶体靶向细胞蛋白降解主要作用一个高度保守的核和细胞质蛋白。它也参与维持染色质结构，基因表达的调节，与应激反应。泛素是合成的由任一多聚泛素链或稠合到一个不相关的蛋白质的单遍在蛋白部分的前体蛋白。该基因编码在C末端由在N末端泛素和核糖体蛋白L40的融合蛋白，C-末端延伸的蛋白（CEP）。从该基因的多个加工假存在于基因组中。 [由RefSeq的，2008年7月提供]
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GCAGCGTCTGATATTTGCC
60
CAGGGTGGACTCTTTCTGG
60
GCAGCGTCTGATATTTGCC
60
CAGGGTGGACTCTTTCTGG
60
GCAGCGTCTGATATTTGCC
60
CAGGGTGGACTCTTTCTGG
60
GCAGCGTCTGATATTTGCC
60
CAGGGTGGACTCTTTCTGG
60
ATATTTGCCGGCAAACAGC
60
CTTTCTGGATGTTGTAGTCTGAG
59
GCAGCGTCTGATATTTGCC
60
CAGGGTGGACTCTTTCTGG
60
GCAGCGTCTGATATTTGCC
60
CAGGGTGGACTCTTTCTGG
60
GCAGCGTCTGATATTTGCC
60
CAGGGTGGACTCTTTCTGG
60
GCAGCGTCTGATATTTGCC
60
CAGGGTGGACTCTTTCTGG
60
GCAGCGTCTGATATTTGCC
60
CAGGGTGGACTCTTTCTGG
60
基因本体信息
UBA52基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
UBA52基因的本体（GO）信息：
GO库代码
对应的蛋白质
来源代码
GO:0003735
M0R1M6 (UniProtKB)
IEA
GO:0005840
M0R1M6 (UniProtKB)
IEA
GO:0006412
M0R1M6 (UniProtKB)
IEA
GO:0003735
M0R2S1 (UniProtKB)
IEA
GO:0005840
M0R2S1 (UniProtKB)
IEA
GO:0006412
M0R2S1 (UniProtKB)
IEA
GO:0000086
P62987 (UniProtKB)
TAS
GO:0000122
P62987 (UniProtKB)
TAS
GO:0000165
P62987 (UniProtKB)
TAS
GO:0000184
P62987 (UniProtKB)
TAS
GO:0000187
P62987 (UniProtKB)
TAS
GO:0000209
P62987 (UniProtKB)
TAS
GO:0000715
P62987 (UniProtKB)
TAS
GO:0000717
P62987 (UniProtKB)
TAS
GO:0002223
P62987 (UniProtKB)
TAS
GO:0002230
P62987 (UniProtKB)
IMP
GO:0002755
P62987 (UniProtKB)
TAS
GO:0002755
P62987 (UniProtKB)
TAS
GO:0002756
P62987 (UniProtKB)
TAS
GO:0003735
P62987 (UniProtKB)
IEA
GO:0003735
P62987 (UniProtKB)
NAS
GO:0005515
P62987 (UniProtKB)
IPI
GO:0005515
P62987 (UniProtKB)
IPI
GO:0005615
P62987 (UniProtKB)
IDA
GO:0005634
P62987 (UniProtKB)
IDA
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005654
P62987 (UniProtKB)
TAS
GO:0005765
P62987 (UniProtKB)
IDA
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005829
P62987 (UniProtKB)
TAS
GO:0005840
P62987 (UniProtKB)
IEA
GO:0005886
P62987 (UniProtKB)
TAS
GO:0005886
P62987 (UniProtKB)
TAS
GO:0005886
P62987 (UniProtKB)
TAS
GO:0005886
P62987 (UniProtKB)
TAS
GO:0005978
P62987 (UniProtKB)
TAS
GO:0006283
P62987 (UniProtKB)
TAS
GO:0006294
P62987 (UniProtKB)
TAS
GO:0006294
P62987 (UniProtKB)
TAS
GO:0006296
P62987 (UniProtKB)
TAS
GO:0006297
P62987 (UniProtKB)
TAS
GO:0006364
P62987 (UniProtKB)
TAS
GO:0006412
P62987 (UniProtKB)
NAS
GO:0006413
P62987 (UniProtKB)
TAS
GO:0006464
P62987 (UniProtKB)
TAS
GO:0006614
P62987 (UniProtKB)
TAS
GO:0006977
P62987 (UniProtKB)
TAS
GO:0007179
P62987 (UniProtKB)
TAS
GO:0007219
P62987 (UniProtKB)
TAS
GO:0007249
P62987 (UniProtKB)
TAS
GO:0007249
P62987 (UniProtKB)
TAS
GO:0007254
P62987 (UniProtKB)
TAS
GO:0008543
P62987 (UniProtKB)
TAS
GO:0008543
P62987 (UniProtKB)
TAS
GO:0008543
P62987 (UniProtKB)
TAS
GO:0008543
P62987 (UniProtKB)
TAS
GO:0010008
P62987 (UniProtKB)
TAS
GO:0010008
P62987 (UniProtKB)
TAS
GO:0010008
P62987 (UniProtKB)
TAS
GO:0010008
P62987 (UniProtKB)
TAS
GO:0010008
P62987 (UniProtKB)
TAS
GO:0010008
P62987 (UniProtKB)
TAS
GO:0010803
P62987 (UniProtKB)
TAS
GO:0010939
P62987 (UniProtKB)
TAS
GO:0016055
P62987 (UniProtKB)
TAS
GO:0016197
P62987 (UniProtKB)
TAS
GO:0016236
P62987 (UniProtKB)
TAS
GO:0019058
P62987 (UniProtKB)
TAS
GO:0019068
P62987 (UniProtKB)
TAS
GO:0019083
P62987 (UniProtKB)
TAS
GO:0019985
P62987 (UniProtKB)
TAS
GO:0022625
P62987 (UniProtKB)
IDA
GO:0030512
P62987 (UniProtKB)
TAS
GO:0030666
P62987 (UniProtKB)
TAS
GO:0031145
P62987 (UniProtKB)
TAS
GO:0031145
P62987 (UniProtKB)
TAS
GO:0031145
P62987 (UniProtKB)
TAS
GO:0032479
P62987 (UniProtKB)
TAS
GO:0032480
P62987 (UniProtKB)
TAS
GO:0033209
P62987 (UniProtKB)
TAS
GO:0033683
P62987 (UniProtKB)
TAS
GO:0034220
P62987 (UniProtKB)
TAS
GO:0035666
P62987 (UniProtKB)
TAS
GO:0035666
P62987 (UniProtKB)
TAS
GO:0036297
P62987 (UniProtKB)
TAS
GO:0038061
P62987 (UniProtKB)
TAS
GO:0038095
P62987 (UniProtKB)
TAS
GO:0038128
P62987 (UniProtKB)
TAS
GO:0042059
P62987 (UniProtKB)
TAS
GO:0042276
P62987 (UniProtKB)
TAS
GO:0042276
P62987 (UniProtKB)
TAS
GO:0042276
P62987 (UniProtKB)
TAS
GO:0042769
P62987 (UniProtKB)
TAS
GO:0042787
P62987 (UniProtKB)
TAS
GO:0042787
P62987 (UniProtKB)
TAS
GO:0042787
P62987 (UniProtKB)
TAS
GO:0042787
P62987 (UniProtKB)
TAS
GO:0042787
P62987 (UniProtKB)
TAS
GO:0043065
P62987 (UniProtKB)
TAS
GO:0043066
P62987 (UniProtKB)
TAS
GO:0043123
P62987 (UniProtKB)
TAS
GO:0043161
P62987 (UniProtKB)
TAS
GO:0043161
P62987 (UniProtKB)
TAS
GO:0043161
P62987 (UniProtKB)
TAS
GO:0043488
P62987 (UniProtKB)
TAS
GO:0044267
P62987 (UniProtKB)
TAS
GO:0045087
P62987 (UniProtKB)
TAS
GO:0045742
P62987 (UniProtKB)
TAS
GO:0045944
P62987 (UniProtKB)
TAS
GO:0050852
P62987 (UniProtKB)
TAS
GO:0051092
P62987 (UniProtKB)
TAS
GO:0051403
P62987 (UniProtKB)
TAS
GO:0051436
P62987 (UniProtKB)
TAS
GO:0051437
P62987 (UniProtKB)
TAS
GO:0060071
P62987 (UniProtKB)
TAS
GO:0061418
P62987 (UniProtKB)
TAS
GO:0070062
P62987 (UniProtKB)
IDA
GO:0070423
P62987 (UniProtKB)
TAS
GO:0070911
P62987 (UniProtKB)
TAS
GO:0070987
P62987 (UniProtKB)
TAS
GO:0075733
P62987 (UniProtKB)
TAS
GO:0090090
P62987 (UniProtKB)
TAS
GO:0090263
P62987 (UniProtKB)
TAS
GO:0098792
P62987 (UniProtKB)
IMP
GO:1901796
P62987 (UniProtKB)
TAS
| 名称 |
|---|
| 3010 Ribosome [PATH:hsa03010] |
| 名称 |
|---|
| 3' -UTR-mediated translational regulation |
| Activated NOTCH1 Transmits Signal to the Nucleus |
| Activated TLR4 signalling |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| Activation of NF-kappaB in B cells |
| Adaptive Immune System |
| Antigen processing-Cross presentation |
| Antigen processing: Ubiquitination & Proteasome degradation |
| Antiviral mechanism by IFN-stimulated genes |
| APC-Cdc20 mediated degradation of Nek2A |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| APC/C-mediated degradation of cell cycle proteins |
| APC/C:Cdc20 mediated degradation of Cyclin B |
| APC/C:Cdc20 mediated degradation of mitotic proteins |
| APC/C:Cdc20 mediated degradation of Securin |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| Apoptosis |
| Assembly Of The HIV Virion |
| Assembly of the pre-replicative complex |
| Association of licensing factors with the pre-replicative complex |
| Asymmetric localization of PCP proteins |
| AUF1 (hnRNP D0) destabilizes mRNA |
| Autodegradation of Cdh1 by Cdh1:APC/C |
| Autodegradation of the E3 ubiquitin ligase COP1 |
| beta-catenin independent WNT signaling |
| Budding and maturation of HIV virion |
| C-type lectin receptors (CLRs) |
| Cap-dependent Translation Initiation |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| CDK-mediated phosphorylation and removal of Cdc6 |
| CDT1 association with the CDC6:ORC:origin complex |
| Cell Cycle |
| Cell Cycle Checkpoints |
| Cell Cycle, Mitotic |
| Cell death signalling via NRAGE, NRIF and NADE |
| Cellular response to hypoxia |
| Cellular responses to stress |
| Cellular Senescence |
| Circadian Clock |
| Class I MHC mediated antigen processing & presentation |
| CLEC7A (Dectin-1) signaling |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| Constitutive Signaling by NOTCH1 HD Domain Mutants |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| Cyclin A:Cdk2-associated events at S phase entry |
| Cyclin D associated events in G1 |
| Cyclin E associated events during G1/S transition |
| Cytokine Signaling in Immune system |
| Cytosolic sensors of pathogen-associated DNA |
| deactivation of the beta-catenin transactivating complex |
| Dectin-1 mediated noncanonical NF-kB signaling |
| degradation of AXIN |
| Degradation of beta-catenin by the destruction complex |
| degradation of DVL |
| Degradation of GLI1 by the proteasome |
| Degradation of GLI2 by the proteasome |
| Disease |
| Diseases of carbohydrate metabolism |
| Diseases of metabolism |
| Diseases of signal transduction |
| DNA Damage Bypass |
| DNA Repair |
| DNA Replication |
| DNA Replication Pre-Initiation |
| Downregulation of ERBB2:ERBB3 signaling |
| Downregulation of ERBB4 signaling |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| Downregulation of TGF-beta receptor signaling |
| Downstream signaling events of B Cell Receptor (BCR) |
| EGFR downregulation |
| Endosomal Sorting Complex Required For Transport (ESCRT) |
| ER-Phagosome pathway |
| Eukaryotic Translation Elongation |
| Eukaryotic Translation Initiation |
| Eukaryotic Translation Termination |
| Fanconi Anemia pathway |
| Formation of a pool of free 40S subunits |
| G1 Phase |
| G1/S DNA Damage Checkpoints |
| G1/S Transition |
| G2/M Transition |
| Gene Expression |
| Generic Transcription Pathway |
| GLI3 is processed to GLI3R by the proteasome |
| Glucose metabolism |
| Glycogen storage diseases |
| Glycogen synthesis |
| GTP hydrolysis and joining of the 60S ribosomal subunit |
| Hedgehog 'off' state |
| Hedgehog 'on' state |
| Hedgehog ligand biogenesis |
| Hh mutants abrogate ligand secretion |
| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD |
| HIV Infection |
| HIV Life Cycle |
| Host Interactions of HIV factors |
| IKK complex recruitment mediated by RIP1 |
| Infectious disease |
| Influenza Infection |
| Influenza Life Cycle |
| Influenza Viral RNA Transcription and Replication |
| Innate Immune System |
| Interferon Signaling |
| Ion channel transport |
| IRAK2 mediated activation of TAK1 complex |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| ISG15 antiviral mechanism |
| L13a-mediated translational silencing of Ceruloplasmin expression |
| Late Phase of HIV Life Cycle |
| M Phase |
| M/G1 Transition |
| Membrane binding and targetting of GAG proteins |
| Membrane Trafficking |
| Metabolism of carbohydrates |
| Metabolism of proteins |
| Mitotic Anaphase |
| Mitotic G1-G1/S phases |
| Mitotic G2-G2/M phases |
| Mitotic Metaphase and Anaphase |
| MyD88 cascade initiated on plasma membrane |
| MyD88 dependent cascade initiated on endosome |
| MyD88-independent TLR3/TLR4 cascade |
| MyD88:Mal cascade initiated on plasma membrane |
| Myoclonic epilepsy of Lafora |
| Negative regulation of FGFR1 signaling |
| Negative regulation of FGFR2 signaling |
| Negative regulation of FGFR3 signaling |
| Negative regulation of FGFR4 signaling |
| Negative regulators of RIG-I/MDA5 signaling |
| NF-kB is activated and signals survival |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| Nonsense-Mediated Decay (NMD) |
| NOTCH1 Intracellular Domain Regulates Transcription |
| NOTCH2 Activation and Transmission of Signal to the Nucleus |
| NRIF signals cell death from the nucleus |
| Oncogene Induced Senescence |
| Orc1 removal from chromatin |
| Oxidative Stress Induced Senescence |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| p53-Dependent G1 DNA Damage Response |
| p53-Dependent G1/S DNA damage checkpoint |
| p53-Independent DNA Damage Response |
| p53-Independent G1/S DNA damage checkpoint |
| p75 NTR receptor-mediated signalling |
| p75NTR recruits signalling complexes |
| p75NTR signals via NF-kB |
| PCP/CE pathway |
| Peptide chain elongation |
| Programmed Cell Death |
| Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| Recognition of DNA damage by PCNA-containing replication complex |
| Regulation of activated PAK-2p34 by proteasome mediated degradation |
| Regulation of APC/C activators between G1/S and early anaphase |
| Regulation of Apoptosis |
| Regulation of DNA replication |
| regulation of FZD by ubiquitination |
| Regulation of Hypoxia-inducible Factor (HIF) by oxygen |
| Regulation of innate immune responses to cytosolic DNA |
| Regulation of mitotic cell cycle |
| Regulation of mRNA stability by proteins that bind AU-rich elements |
| Regulation of PLK1 Activity at G2/M Transition |
| Regulation of the Fanconi anemia pathway |
| Removal of licensing factors from origins |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| S Phase |
| SCF-beta-TrCP mediated degradation of Emi1 |
| SCF(Skp2)-mediated degradation of p27/p21 |
| Senescence-Associated Secretory Phenotype (SASP) |
| Separation of Sister Chromatids |
| Signaling by EGFR |
| Signaling by EGFR in Cancer |
| Signaling by ERBB2 |
| Signaling by ERBB4 |
| Signaling by FGFR |
| Signaling by FGFR1 |
| Signaling by FGFR2 |
| Signaling by FGFR3 |
| Signaling by FGFR4 |
| Signaling by Hedgehog |
| Signaling by Ligand-Responsive EGFR Variants in Cancer |
| Signaling by NOTCH |
| Signaling by NOTCH1 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| Signaling by NOTCH1 in Cancer |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| Signaling by NOTCH2 |
| Signaling by TGF-beta Receptor Complex |
| Signaling by the B Cell Receptor (BCR) |
| Signaling by Wnt |
| Signalling by NGF |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| Spry regulation of FGF signaling |
| SRP-dependent cotranslational protein targeting to membrane |
| Stabilization of p53 |
| Stimuli-sensing channels |
| Switching of origins to a post-replicative state |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins |
| Synthesis of DNA |
| TCF dependent signaling in response to WNT |
| Termination of translesion DNA synthesis |
| TGF-beta receptor signaling activates SMADs |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| Toll Like Receptor 10 (TLR10) Cascade |
| Toll Like Receptor 2 (TLR2) Cascade |
| Toll Like Receptor 3 (TLR3) Cascade |
| Toll Like Receptor 4 (TLR4) Cascade |
| Toll Like Receptor 5 (TLR5) Cascade |
| Toll Like Receptor 7/8 (TLR7/8) Cascade |
| Toll Like Receptor 9 (TLR9) Cascade |
| Toll Like Receptor TLR1:TLR2 Cascade |
| Toll Like Receptor TLR6:TLR2 Cascade |
| Toll-Like Receptors Cascades |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| TRAF6 Mediated Induction of proinflammatory cytokines |
| TRAF6 mediated induction of TAK1 complex |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| Translation |
| Translesion Synthesis by POLH |
| Translesion synthesis by POLI |
| Translesion synthesis by POLK |
| Translesion synthesis by REV1 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| Transmembrane transport of small molecules |
| TRIF-mediated TLR3/TLR4 signaling |
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |
| Ubiquitin-dependent degradation of Cyclin D |
| Ubiquitin-dependent degradation of Cyclin D1 |
| Vesicle-mediated transport |
| Vif-mediated degradation of APOBEC3G |
| Viral mRNA Translation |
| Vpu mediated degradation of CD4 |
联系方式
山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室
山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼
电话： 0531-88819269
E-mail: product@genelibs.com
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
