This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]
该基因位于染色体9P那窝藏抑癌基因在肿瘤发生中的关键区域内。它是其在非小细胞肺癌和小细胞肺癌细胞系表达下调,这表明它可能在肺癌肿瘤发生中发挥作用的无内含子的基因。 [由RefSeq的,2008年7月提供]
TUSC1基因(以及对应的蛋白质)的细胞分布位置:
TUSC1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Skin Neoplasms | 0.002367032 | 1 | 0 | GAD |
Drug-Induced Liver Injury | 0.002367032 | 1 | 1 | GAD |
Nevus | 0.002367032 | 1 | 0 | GAD |
gallbladder neoplasm | 0.002367032 | 1 | 1 | GAD |
Hematocrit level | 0.002367032 | 1 | 1 | GAD |
melanoma | 0.002367032 | 1 | 0 | GAD |
Carotid Artery Diseases | 0.002367032 | 1 | 3 | GAD |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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