TSIX (TSIX transcript, XIST antisense RNA)
- symbol:
- TSIX
- locus group:
- non-coding RNA
- location:
- Xq13.2
- gene_family:
- Long non-coding RNAs (published)
- alias symbol:
- NCRNA00013|XIST-AS1|LINC00013
- alias name:
- XIST antisense RNA (non-protein co…
- entrez id:
- 9383
- ensembl gene id:
- ENSG00000270641
- ucsc gene id:
- uc004ebn.2
- refseq accession:
- NR_003255
- hgnc_id:
- HGNC:12377
- approved reserved:
- 1999-09-28
In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. The mouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xist through modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivation does not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression or affect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend over more than 30 kb, but its exact nature has not been determined. [provided by RefSeq, Jul 2008]
在哺乳动物中，在X染色体上的基因的剂量补偿由X染色体失活，这是在顺式由X染色体失活中心（XIC）和表达的XIST非编码RNA的调节发生。该基因表达横跨XIST轨迹的3‘端的非编码的反义转录物，并且共表达与只从失活的X染色体XIST。该位点的小鼠直向同源物时需要在胚外组织印迹X染色体失活，并通过在Xist基因启动子区的染色质结构的修饰沉默Xist的。相比之下，印X染色体失活并没有在人类胚外组织和成绩单从这个位点发生不压制XIST表达或胚胎细胞影响的随机X染色体失活。这份成绩单被认为是未拼接并延伸超过30 KB，但其确切性质尚未确定。 [由RefSeq的，2008年7月提供]
基因本体信息
TSIX基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
TSIX基因的本体（GO）信息：
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