TSG101 (tumor susceptibility 101)

基因基本信息

基因基本信息

symbol:
TSG101
locus group:
protein-coding gene
location:
11p15.1
gene_family:
alias symbol:
VPS23
alias name:
None
entrez id:
7251
ensembl gene id:
ENSG00000074319
ucsc gene id:
uc001mor.4
refseq accession:
NM_006292
hgnc_id:
HGNC:15971
approved reserved:
2001-07-20

基因染色体位置

基因染色体位置

11p15.1
基因染色体位置图

基因简述

基因简述

TSG101（肿瘤易感基因101，Tumor Susceptibility Gene 101）是一种重要的多功能蛋白，属于ESCRT（内体分选复合物转运所需复合物，Endosomal Sorting Complex Required for Transport）家族中的ESCRT-I复合体成员。该基因家族（ESCRT家族）主要负责调控细胞内膜运输过程，如多泡体（MVB，Multivesicular Body）形成、细胞膜修复、病毒出芽及细胞分裂等，其共性是通过一系列蛋白复合物（ESCRT-0至III）协同作用，介导泛素化蛋白的分选和膜重塑。TSG101作为ESCRT-I的核心组分，直接参与识别泛素化（一种标记蛋白质降解的修饰）的膜蛋白，并将其分选至溶酶体降解途径，从而调控表皮生长因子受体（EGFR）等信号蛋白的稳态。此外，TSG101还通过稳定p53蛋白（一种抑癌蛋白）抑制肿瘤发生，并在HIV等病毒出芽过程中被劫持以协助病毒释放。TSG101的突变或表达异常会导致其功能紊乱，例如错义突变可能破坏ESCRT-I复合体组装，导致泛素化蛋白积累，引发神经退行性疾病（如阿尔茨海默病）或癌症（如乳腺癌、卵巢癌）。若TSG101过表达，可能过度激活膜运输途径，干扰正常信号传导，甚至促进肿瘤转移；而表达降低则会导致受损蛋白清除障碍，诱发细胞凋亡或基因组不稳定性。研究还发现，TSG101与某些病毒感染（如HPV、埃博拉病毒）密切相关，因其参与病毒粒子释放。该基因的调控异常也可能影响其他ESCRT成员（如VPS4）的功能，进一步破坏内体系统平衡。

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质属于一组泛素结合酶的明显无活性同系物的。的基因产物包含与stathmin的，胞质磷蛋白在肿瘤牵连相互作用的卷曲螺旋结构域。该蛋白可能在细胞生长和分化并充当一个角色作为负生长调节剂。在这种肿瘤易感基因的体外稳态表达似乎是维护基因组稳定性和细胞周期调控的重要。突变和选择性剪接在这个基因发生在乳腺癌高频并表明乳腺癌肿瘤发生和/或进展过程中发生的缺陷。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

TSG101基因的碱基突变：           仅显示部分snp
rs372258462       rs544088438       rs555066489       rs555916899       rs557400367       rs558281305       rs562399479       rs574397405       rs576771638       rs8018       rs15387       rs171496       rs181714       rs868069       rs1395319       rs1395320       rs1804795      

基因表达

基因表达

TSG101基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AATCCCTGTGCCTTATAGAGG
59
CTGACTGTGGGTGTTTCCA
60
AATCCCAGTGGTTACCCAG
59
GAGGCTGAGAAGGGTACTG
59
TCTTCCTGAAGCATGTACGT
59
GTAGAGGTCACTGAGACCG
59
GTTTAGATCAAGAAGTAGCCGA
58
TTTCCAGAGCAGAACTGAG
57
ACAGATCCTGAATCTGTATGC
58
CACTGAAGTCTTCAGGAAGAC
58
TGGTGTCCAAGTTATAGAAGAC
58
AGTTTCACGTACAGTTAGGTC
58
AGATGAACCTCCAGTCTTCTC
59
ATGTAGGAAGTATTTGGTGGC
58
CACTGTTGGTCCCAGTAGG
60
GCCATCTCAGTTTGTCACTG
59
TGAATGGAAACACCCACAG
58
GAAGACTGGAGGTTCATCTC
57
TGCCTTATAGAGCCACAGTC
59
AGAAGACTGGAGGTTCATCTC
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
MAZ
TSG101
Activation
21556761
TSG101
CEP55
Unknown
18948538
TSG101
EGFR
Repression
19154774
TSG101
REG4
Repression
18643869
TTF2
TSG101
Unknown
21556761

基因本体信息

TSG101基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

TSG101基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005730
F5H442 (UniProtKB)
IDA
GO:0005737
F5H442 (UniProtKB)
IDA
GO:0005886
F5H442 (UniProtKB)
IDA
GO:0006464
F5H442 (UniProtKB)
IEA
GO:0015031
F5H442 (UniProtKB)
IEA
GO:0000813
Q99816 (UniProtKB)
IDA
GO:0000813
Q99816 (UniProtKB)
TAS
GO:0000813
Q99816 (UniProtKB)
IDA
GO:0000813
Q99816 (UniProtKB)
TAS
GO:0000813
Q99816 (UniProtKB)
IDA
GO:0000813
Q99816 (UniProtKB)
IDA
GO:0001558
Q99816 (UniProtKB)
IEA
GO:0003677
Q99816 (UniProtKB)
TAS
GO:0003714
Q99816 (UniProtKB)
IEA
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005515
Q99816 (UniProtKB)
IPI
GO:0005730
Q99816 (UniProtKB)
IDA
GO:0005737
Q99816 (UniProtKB)
ISS
GO:0005737
Q99816 (UniProtKB)
IDA
GO:0005737
Q99816 (UniProtKB)
IDA
GO:0005768
Q99816 (UniProtKB)
IDA
GO:0005769
Q99816 (UniProtKB)
IDA
GO:0005769
Q99816 (UniProtKB)
IDA
GO:0005770
Q99816 (UniProtKB)
IMP
GO:0005771
Q99816 (UniProtKB)
TAS
GO:0005886
Q99816 (UniProtKB)
IDA
GO:0005886
Q99816 (UniProtKB)
IDA
GO:0006513
Q99816 (UniProtKB)
IEA
GO:0006914
Q99816 (UniProtKB)
TAS
GO:0007050
Q99816 (UniProtKB)
IEA
GO:0008285
Q99816 (UniProtKB)
IEA
GO:0008333
Q99816 (UniProtKB)
IEA
GO:0010008
Q99816 (UniProtKB)
TAS
GO:0010008
Q99816 (UniProtKB)
TAS
GO:0010008
Q99816 (UniProtKB)
TAS
GO:0010008
Q99816 (UniProtKB)
TAS
GO:0010008
Q99816 (UniProtKB)
TAS
GO:0015031
Q99816 (UniProtKB)
IEA
GO:0016197
Q99816 (UniProtKB)
TAS
GO:0019058
Q99816 (UniProtKB)
TAS
GO:0030216
Q99816 (UniProtKB)
IEA
GO:0030374
Q99816 (UniProtKB)
IEA
GO:0031625
Q99816 (UniProtKB)
IPI
GO:0031902
Q99816 (UniProtKB)
IEA
GO:0036258
Q99816 (UniProtKB)
TAS
GO:0039702
Q99816 (UniProtKB)
TAS
GO:0042803
Q99816 (UniProtKB)
IPI
GO:0043130
Q99816 (UniProtKB)
IDA
GO:0043130
Q99816 (UniProtKB)
IDA
GO:0043130
Q99816 (UniProtKB)
TAS
GO:0043130
Q99816 (UniProtKB)
IDA
GO:0043162
Q99816 (UniProtKB)
IDA
GO:0043162
Q99816 (UniProtKB)
IC
GO:0043162
Q99816 (UniProtKB)
IMP
GO:0043405
Q99816 (UniProtKB)
IMP
GO:0045892
Q99816 (UniProtKB)
IEA
GO:0046755
Q99816 (UniProtKB)
ISS
GO:0046755
Q99816 (UniProtKB)
IMP
GO:0046790
Q99816 (UniProtKB)
IDA
GO:0048306
Q99816 (UniProtKB)
IPI
GO:0048524
Q99816 (UniProtKB)
IMP
GO:0051301
Q99816 (UniProtKB)
IEA
GO:0070062
Q99816 (UniProtKB)
IDA
GO:0070062
Q99816 (UniProtKB)
IDA
GO:0070062
Q99816 (UniProtKB)
IDA
GO:0070062
Q99816 (UniProtKB)
IDA
GO:0070062
Q99816 (UniProtKB)
IDA
GO:0070062
Q99816 (UniProtKB)
IDA
GO:0075733
Q99816 (UniProtKB)
TAS
GO:0097352
Q99816 (UniProtKB)
TAS
GO:1902188
Q99816 (UniProtKB)
IMP
GO:1902188
Q99816 (UniProtKB)
IMP
GO:1903543
Q99816 (UniProtKB)
IMP
GO:1903543
Q99816 (UniProtKB)
IMP
GO:1903551
Q99816 (UniProtKB)
IMP
GO:1903772
Q99816 (UniProtKB)
IMP
GO:1903774
Q99816 (UniProtKB)
IMP
GO:1903774
Q99816 (UniProtKB)
IMP
GO:2000397
Q99816 (UniProtKB)
IEA
GO:1902186
Q99816 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 TSG101基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Breast Cancer, Familial 0.120814326 3 0 BeFree_CLINVAR
Malignant neoplasm of breast 0.005700279 21 0 BeFree
ovarian neoplasm 0.0054487 2 0 LHGDN
Breast Carcinoma 0.004885954 18 0 BeFree
Carcinogenesis 0.004614512 17 0 BeFree
Malignant neoplasm of lung 0.003181358 4 0 BeFree_GAD
HIV Infections 0.002442977 9 0 BeFree
Hepatitis C 0.002367032 1 0 GAD
Chronic Obstructive Airway Disease 0.002367032 1 0 GAD
Malignant neoplasm of urinary bladder 0.002367032 1 0 GAD

基因相关服务

基因相关服务

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