TP73 (tumor protein p73)

基因基本信息

基因基本信息

symbol:
TP73
locus group:
protein-coding gene
location:
1p36.32
gene_family:
alias symbol:
P73
alias name:
None
entrez id:
7161
ensembl gene id:
ENSG00000078900
ucsc gene id:
uc001akp.4
refseq accession:
NM_005427
hgnc_id:
HGNC:12003
approved reserved:
1997-11-12

基因染色体位置

基因染色体位置

1p36.32
基因染色体位置图

基因简述

基因简述

TP73是p53基因家族的重要成员，该家族还包括TP53和TP63，它们共同编码转录因子，参与细胞周期调控、DNA修复和凋亡等关键生物学过程。TP73基因通过选择性剪接产生多种异构体（如TAp73和ΔNp73），其中TAp73具有抑癌功能，能激活下游靶基因（如p21、BAX）诱导细胞周期停滞或凋亡；而ΔNp73作为显性负调控因子，会抑制TAp73和p53的功能。TP73在神经系统发育、免疫调节和生殖系统中发挥重要作用，其表达具有组织特异性，例如在脑和睾丸中较高。TP73突变或表达异常与多种癌症相关，过表达TAp73可能增强抗癌效应，但ΔNp73过表达会促进肿瘤进展（如神经母细胞瘤、卵巢癌）。降低TP73表达可能导致发育缺陷或削弱DNA损伤应答。该基因的启动子甲基化或拷贝数变异也会影响其功能。p53家族基因的共性是均含DNA结合结构域，通过四聚化发挥作用，但各自又有独特功能：TP53主攻应激响应，TP63侧重上皮发育，TP73则更多参与神经分化。需要注意的是，TP73的某些异构体（如TAp73β）还能调控代谢相关基因（如GLUT1）。目前"异构体"（isoform）和"显性负调控"（dominant-negative）等术语的中文翻译存在争议，部分文献仍保留英文原词。

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

该基因编码的p53家族参与向应力和发展细胞应答的转录因子的成员。它映射到对染色体1p36区域是神经母细胞瘤等肿瘤频繁删除，并认为含有多肿瘤抑制基因。该基因是monoallelically表示的示范（可能从母体等位基因），支持的概念，它是对神经母细胞瘤的候选基因。从选择性剪接和/或使用替代型启动子的导致许多转录物的变体已被发现对于此基因，但生物有效性和某些变体的全长性质尚未确定。 [由RefSeq的，2011年2月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

TP73基因的碱基突变：           仅显示部分snp
rs1122638       rs1122639       rs1122723       rs1122724       rs1122725       rs2368542       rs3765702       rs3765703       rs3819954       rs6665164       rs7554226       rs10910007       rs10910008       rs12027041       rs12028205       rs12057230       rs12062249      

基因表达

基因表达

TP73基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGCATCTGTCAGTGTCTCC
59
AGATTGAACTGGGCCTGTC
60
GTACTACCTTCAGGTGCGA
59
GATAGGAGTCCACCAGTGG
59
AGACAGCACCTACTTCGAC
59
GATTGAACTGGGCCATGAC
59
CTTCAACGAAGGACAGTCTG
59
AGGGTCATCCACATACTGC
59
GTACTACCTTCAGGTGCGA
58
GATAGGAGTCCACCAGTGG
58
AGACAGCACCTACTTCGAC
59
GATTGAACTGGGCCATGAC
59
CTTCAACGAAGGACAGTCTG
59
AGGGTCATCCACATACTGC
59
AGACAGCACCTACTTCGAC
59
GATTGAACTGGGCCATGAC
59
AGACAGCACCTACTTCGAC
59
GATTGAACTGGGCCATGAC
59
AGACAGCACCTACTTCGAC
59
GATTGAACTGGGCCATGAC
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
E2F1
TP73
Activation
11115495; 12766778; 17980704
E2F1
TP73
Unknown
11988839; 19188449
EGR1
TP73
Unknown
16990849
EP300
TP73
Activation
11115495
JUN
TP73
Unknown
15302867
KAT2B
TP73
Unknown
19188449
MYC
TP73
Activation
11115495
SIRT1
TP73
Unknown
19188449
TP53
TP73
Unknown
11238924; 16990849
TP73
AQP3
Unknown
11231003

基因本体信息

TP73基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

TP73基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003700
A0A0C4DFW9 (UniProtKB)
IEA
GO:0005634
A0A0C4DFW9 (UniProtKB)
IEA
GO:0005737
A0A0C4DFW9 (UniProtKB)
IEA
GO:0006351
A0A0C4DFW9 (UniProtKB)
IEA
GO:0006355
A0A0C4DFW9 (UniProtKB)
IEA
GO:0006915
A0A0C4DFW9 (UniProtKB)
IEA
GO:0007050
A0A0C4DFW9 (UniProtKB)
IEA
GO:0044212
A0A0C4DFW9 (UniProtKB)
IEA
GO:0046872
A0A0C4DFW9 (UniProtKB)
IEA
GO:0051262
A0A0C4DFW9 (UniProtKB)
IEA
GO:0000122
O15350 (UniProtKB)
IBA
GO:0000187
O15350 (UniProtKB)
IEA
GO:0000785
O15350 (UniProtKB)
IBA
GO:0000978
O15350 (UniProtKB)
IDA
GO:0000981
O15350 (UniProtKB)
IDA
GO:0001077
O15350 (UniProtKB)
IDA
GO:0001822
O15350 (UniProtKB)
IEA
GO:0002039
O15350 (UniProtKB)
IBA
GO:0003682
O15350 (UniProtKB)
IBA
GO:0003684
O15350 (UniProtKB)
IBA
GO:0003700
O15350 (UniProtKB)
IDA
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005515
O15350 (UniProtKB)
IPI
GO:0005634
O15350 (UniProtKB)
IDA
GO:0005634
O15350 (UniProtKB)
IDA
GO:0005634
O15350 (UniProtKB)
IDA
GO:0005634
O15350 (UniProtKB)
IDA
GO:0005654
O15350 (UniProtKB)
IDA
GO:0005654
O15350 (UniProtKB)
TAS
GO:0005654
O15350 (UniProtKB)
TAS
GO:0005654
O15350 (UniProtKB)
TAS
GO:0005654
O15350 (UniProtKB)
TAS
GO:0005654
O15350 (UniProtKB)
TAS
GO:0005654
O15350 (UniProtKB)
TAS
GO:0005654
O15350 (UniProtKB)
TAS
GO:0005667
O15350 (UniProtKB)
IBA
GO:0005739
O15350 (UniProtKB)
IEA
GO:0005794
O15350 (UniProtKB)
IDA
GO:0005829
O15350 (UniProtKB)
IBA
GO:0006298
O15350 (UniProtKB)
TAS
GO:0006366
O15350 (UniProtKB)
IEA
GO:0006974
O15350 (UniProtKB)
IDA
GO:0006978
O15350 (UniProtKB)
IBA
GO:0007050
O15350 (UniProtKB)
IEA
GO:0007346
O15350 (UniProtKB)
IMP
GO:0008134
O15350 (UniProtKB)
IPI
GO:0008134
O15350 (UniProtKB)
IPI
GO:0008285
O15350 (UniProtKB)
IMP
GO:0008285
O15350 (UniProtKB)
IMP
GO:0008630
O15350 (UniProtKB)
TAS
GO:0010165
O15350 (UniProtKB)
IBA
GO:0010243
O15350 (UniProtKB)
IEA
GO:0010332
O15350 (UniProtKB)
IBA
GO:0010468
O15350 (UniProtKB)
IMP
GO:0016032
O15350 (UniProtKB)
IEA
GO:0019901
O15350 (UniProtKB)
IPI
GO:0019901
O15350 (UniProtKB)
IPI
GO:0030054
O15350 (UniProtKB)
IDA
GO:0031571
O15350 (UniProtKB)
IBA
GO:0034644
O15350 (UniProtKB)
IBA
GO:0042493
O15350 (UniProtKB)
IEA
GO:0042771
O15350 (UniProtKB)
IDA
GO:0042771
O15350 (UniProtKB)
IDA
GO:0042802
O15350 (UniProtKB)
IPI
GO:0042981
O15350 (UniProtKB)
TAS
GO:0043231
O15350 (UniProtKB)
IDA
GO:0043508
O15350 (UniProtKB)
IBA
GO:0043524
O15350 (UniProtKB)
IBA
GO:0044212
O15350 (UniProtKB)
IDA
GO:0045665
O15350 (UniProtKB)
IEA
GO:0045893
O15350 (UniProtKB)
IDA
GO:0045893
O15350 (UniProtKB)
IDA
GO:0045944
O15350 (UniProtKB)
IDA
GO:0045944
O15350 (UniProtKB)
IDA
GO:0045944
O15350 (UniProtKB)
IDA
GO:0045944
O15350 (UniProtKB)
IDA
GO:0045944
O15350 (UniProtKB)
IDA
GO:0046872
O15350 (UniProtKB)
IEA
GO:0048714
O15350 (UniProtKB)
IEA
GO:0051262
O15350 (UniProtKB)
IEA
GO:0060044
O15350 (UniProtKB)
IMP
GO:0071158
O15350 (UniProtKB)
IDA
GO:1900740
O15350 (UniProtKB)
TAS
GO:1901796
O15350 (UniProtKB)
TAS

基因相关microRNA

基因相关microRNA

可能调控 TP73基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Alveolar rhabdomyosarcoma 0.12 1 0 CTD_human
Small cell carcinoma of lung 0.12 0 0 ORPHANET
Adult T-Cell Lymphoma/Leukemia 0.12 1 0 CTD_human
Neurologic Manifestations 0.08 1 0 CTD_mouse
Congenital neurologic anomalies 0.08 1 0 CTD_mouse
OTITIS MEDIA, SUSCEPTIBILITY TO (finding) 0.08 0 0 MGD
Squamous cell carcinoma 0.024066026 16 0 BeFree_GAD_LHGDN
Malignant neoplasm of lung 0.023279326 21 1 BeFree_GAD
Carcinogenesis 0.016557954 61 2 BeFree
Neuroblastoma 0.011681932 33 0 BeFree_LHGDN

基因相关服务

基因相关服务

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