TNFRSF25 (TNF receptor superfamily member 25)
- symbol:
- TNFRSF25
- locus group:
- protein-coding gene
- location:
- 1p36.31
- gene_family:
- Tumor necrosis factor receptor superfamily
- alias symbol:
- DR3|TRAMP|WSL-1|LARD|WSL-LR|DDR3|TR3|APO-3
- alias name:
- None
- entrez id:
- 8718
- ensembl gene id:
- ENSG00000215788
- ucsc gene id:
- uc001anh.4
- refseq accession:
- NM_148965
- hgnc_id:
- HGNC:11910
- approved reserved:
- 1998-12-04
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质是TNF受体超家族的成员。这种受体是表达优先在淋巴细胞富集的组织，并且它可以在调节淋巴细胞动态平衡的作用。该受体已显示刺激的NF-κB的活性，调节细胞凋亡。这种受体的信号转导是由各种含死亡域接头蛋白介导的。在小鼠中敲除研究显示该基因在胸腺切除自反应性T细胞的作用。这个基因编码不同同种型的多个可变剪接转录物变体已有报道，其中大部分是潜在的分泌的分子。该基因在B和T细胞的选择性剪接遇到在T细胞活化编程??的变化，这主要产生全长膜结合同种型，并且被认为是涉及控制由T细胞活化诱导的淋巴细胞增殖。 [由RefSeq的，2008年7月提供]
基因本体信息
TNFRSF25基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
TNFRSF25基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Malignant neoplasm of prostate | 0.00868614 | 32 | 0 | BeFree |
| Prostate carcinoma | 0.008414698 | 31 | 0 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.007372538 | 3 | 0 | BeFree_GAD |
| Rheumatoid Arthritis | 0.00408156 | 5 | 0 | BeFree_LHGDN |
| Atherosclerosis | 0.00272435 | 1 | 0 | LHGDN |
| Pneumonia | 0.00272435 | 1 | 0 | LHGDN |
| Multiple Myeloma | 0.002367032 | 1 | 0 | GAD |
| Prostatic Neoplasms | 0.002171535 | 8 | 0 | BeFree |
| Neoplasm Metastasis | 0.001085767 | 4 | 0 | BeFree |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
