TNFRSF10C (TNF receptor superfamily member 10c)
- symbol:
- TNFRSF10C
- locus group:
- protein-coding gene
- location:
- 8p21.3
- gene_family:
- CD molecules|Tumor necrosis factor receptor superfamily
- alias symbol:
- DcR1|TRAILR3|LIT|TRID|CD263
- alias name:
- None
- entrez id:
- 8794
- ensembl gene id:
- ENSG00000173535
- ucsc gene id:
- uc003xcy.4
- refseq accession:
- NM_003841
- hgnc_id:
- HGNC:11906
- approved reserved:
- 1998-12-04
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质是TNF受体超家族的成员。该受体包含胞外TRAIL结合结构域和跨膜结构域，但没有胞质死亡域。该受体是不能够诱导细胞凋亡的，并且被认为充当保护细胞免于TRAIL诱导的细胞凋亡的拮抗受体。该基因被认为是一个p53-调节的DNA损伤 - 诱导型基因。在许多正常组织中检测到该基因的表达，但在大多数肿瘤细胞系，这可以解释癌细胞的具体灵敏度对TRAIL的细胞凋亡诱导活性。 [由RefSeq的，2008年7月提供]
基因本体信息
TNFRSF10C基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
TNFRSF10C基因的本体（GO）信息：
| 名称 |
|---|
| 4060 Cytokine-cytokine receptor interaction [PATH:hsa04060] |
| 4210 Apoptosis [PATH:hsa04210] |
| 4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650] |
| 5162 Measles [PATH:hsa05162] |
| 5164 Influenza A [PATH:hsa05164] |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
| Prostatic Neoplasms | 0.005720142 | 2 | 0 | BeFree_LHGDN |
| Eosinophilia | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Leukemia, Myelocytic, Acute | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Churg-Strauss Syndrome | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Pancreatitis, Chronic | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of breast | 0.002638474 | 2 | 0 | BeFree_GAD |
| Multiple Myeloma | 0.002367032 | 1 | 0 | GAD |
| melanoma | 0.000814326 | 3 | 0 | BeFree |
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