TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2)
- symbol:
- TMEFF2
- locus group:
- protein-coding gene
- location:
- 2q32.3
- gene_family:
- alias symbol:
- TENB2|HPP1|TR|TPEF|CT120.2
- alias name:
- transmembrane protein TENB2|tomore…
- entrez id:
- 23671
- ensembl gene id:
- ENSG00000144339
- ucsc gene id:
- uc002utc.4
- refseq accession:
- NM_016192
- hgnc_id:
- HGNC:11867
- approved reserved:
- 1998-10-02
This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
该基??因编码的tomoregulin家族的跨膜蛋白的成员。此蛋白已被示出为根据蜂窝上下文既致癌基因和肿瘤抑制和可调节前列腺癌细胞侵袭的功能。这种蛋白质的多种可溶形式已被确定使得来自两个备选剪接变体和胞外域脱落引起的。此外，该基因已被发现在多种癌症类型被甲基化。选择性剪接结果在多个抄本变形。 [由RefSeq的，2015年2月提供]
基因本体信息
TMEFF2基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
TMEFF2基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Diabetes Mellitus | 0.122367032 | 1 | 1 | GAD_GWASCAT |
| Prostatic Neoplasms | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Polycystic Ovary Syndrome | 0.12 | 1 | 0 | CTD_human |
| Diabetes | 0.12 | 1 | 1 | GWASCAT |
| Colorectal Neoplasms | 0.008173051 | 3 | 0 | LHGDN |
| Adenocarcinoma | 0.006534468 | 4 | 0 | BeFree_LHGDN |
| Colorectal Cancer | 0.002985861 | 11 | 0 | BeFree |
| Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Bladder Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Esophageal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
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