TLR3 (toll like receptor 3)

基因基本信息

基因基本信息

symbol:
TLR3
locus group:
protein-coding gene
location:
4q35.1
gene_family:
CD molecules
alias symbol:
CD283
alias name:
None
entrez id:
7098
ensembl gene id:
ENSG00000164342
ucsc gene id:
uc003iyq.4
refseq accession:
NM_003265
hgnc_id:
HGNC:11849
approved reserved:
1998-06-25

基因染色体位置

基因染色体位置

4q35.1
基因染色体位置图

基因简述

基因简述

TLR3（Toll样受体3，Toll-like receptor 3）属于Toll样受体（TLR）家族，该家族是一类模式识别受体（PRR），主要识别病原体相关分子模式（PAMP），如病毒双链RNA（dsRNA），在先天免疫应答中起关键作用。TLR3主要表达于免疫细胞（如树突状细胞、巨噬细胞）及上皮细胞内，其功能是通过识别病毒dsRNA激活下游信号通路（如TRIF依赖途径），诱导I型干扰素（IFN-α/β）和促炎细胞因子（如IL-6、TNF-α）的产生，从而启动抗病毒免疫反应。TLR3的突变可能导致功能丧失，增加对疱疹病毒等感染的易感性，或引发自身炎症性疾病；某些突变（如P554S）与儿童单纯疱疹病毒性脑炎（HSE）的遗传易感性相关。TLR3过表达可能增强抗病毒反应，但过度激活会引发细胞因子风暴（如COVID-19重症中的免疫病理损伤）；而表达降低则可能导致免疫逃逸或慢性感染。TLR家族（TLR1-13）的共同特点是具有富含亮氨酸重复序列（LRR）的胞外域和TIR（Toll/IL-1受体同源）胞内域，通过识别不同病原体成分（如细菌脂多糖、病毒核酸）协调免疫防御。TLR3的独特之处在于其依赖内体（endosome）定位及特异性识别dsRNA，与其他TLR（如TLR4识别LPS）形成互补。

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白是Toll样受体（TLR）家族中起着病原体识别和先天免疫激活的基础性作用的成员。 Toll样受体是高度果蝇保守到人类和共享结构和功能的相似性。他们认识到是在感染剂表达的病原体相关分子模式（PAMP），并介导的生产所必需的有效免疫的发展细胞因子。各种Toll样受体表现出不同的表达模式。此受体在胎盘和胰腺最大量表达，并且被限制在白细胞的树突状细胞亚群。它识别双链RNA与病毒感染有关，并诱导的NF-κB的活化和生产I型干扰素。因此，它可以起到对病毒宿主防御的作用。替代多聚腺苷酸化位点用来生成不同长度的成绩单已经注意到了这个基因。 [由RefSeq的，2008年7月提供]

OMIM数据库中对TLR3基因的介绍     Wikipedia数据库中对TLR3基因的介绍

基因序列

基因序列

TLR3基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

TLR3基因的碱基突变：           仅显示部分snp
rs1540793       rs1568358       rs1879026       rs1970870       rs1976802       rs1996594       rs2310393       rs3775290       rs3775291       rs3775292       rs3775293       rs3775294       rs3775295       rs3775296       rs5743303       rs5743304       rs5743305      

基因表达

基因表达

TLR3基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGATTCAAGGTACATCATGCAG
59
TCTGGAATCTCCTCAAGGA
57
GTCATCCAACAGAATCATGAGAC
60
CTAACAGTGCACTTGGTGG
59
AAGAAAGGGACTTTGAGGC
58
GTTGAACTGCATGATGTACCT
59
GTCATCCAACAGAATCATGAGAC
60
CTAACAGTGCACTTGGTGG
59
GAGGCTGGAGTAAGAGGTG
59
GGCCAAATAATCTTCCAATTGC
59
AAGAAAGGGACTTTGAGGC
58
GTTGAACTGCATGATGTACCT
59
GAAGAAAGGGACTTTGAGGC
59
TTGAACTGCATGATGTACCT
57
GAAGAAAGGGACTTTGAGGC
59
TTGAACTGCATGATGTACCT
57
AGAGGCTGGAGTAAGAGGT
59
GCCAAATAATCTTCCAATTGCG
59
GTCATCCAACAGAATCATGAGAC
60
TAACAGTGCACTTGGTGGT
60

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
E2F1
TLR3
Repression
22310660
IRF3
TLR3
Unknown
22208359
IRF8
TLR3
Repression
21220691
NFKB1
TLR3
Activation
20658750
NFKB1
TLR3
Repression
16423052
RELA
TLR3
Activation
20658750
RELA
TLR3
Repression
16423052
STAT1
TLR3
Activation
16628196

基因本体信息

TLR3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

TLR3基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0002756
D6RA51 (UniProtKB)
IEA
GO:0003725
D6RA51 (UniProtKB)
IEA
GO:0004888
D6RA51 (UniProtKB)
IEA
GO:0016021
D6RA51 (UniProtKB)
IEA
GO:0032722
D6RA51 (UniProtKB)
IEA
GO:0034138
D6RA51 (UniProtKB)
IEA
GO:0043330
D6RA51 (UniProtKB)
IEA
GO:0045087
D6RA51 (UniProtKB)
IEA
GO:0050729
D6RA51 (UniProtKB)
IEA
GO:0051607
D6RA51 (UniProtKB)
IEA
GO:0000139
O15455 (UniProtKB)
TAS
GO:0000139
O15455 (UniProtKB)
TAS
GO:0002224
O15455 (UniProtKB)
TAS
GO:0002282
O15455 (UniProtKB)
IEA
GO:0002730
O15455 (UniProtKB)
IEA
GO:0002756
O15455 (UniProtKB)
TAS
GO:0003725
O15455 (UniProtKB)
NAS
GO:0003725
O15455 (UniProtKB)
IDA
GO:0004872
O15455 (UniProtKB)
TAS
GO:0004888
O15455 (UniProtKB)
NAS
GO:0005515
O15455 (UniProtKB)
IPI
GO:0005515
O15455 (UniProtKB)
IPI
GO:0005515
O15455 (UniProtKB)
IPI
GO:0005622
O15455 (UniProtKB)
IDA
GO:0005737
O15455 (UniProtKB)
IDA
GO:0005765
O15455 (UniProtKB)
IDA
GO:0005769
O15455 (UniProtKB)
IEA
GO:0005789
O15455 (UniProtKB)
TAS
GO:0005789
O15455 (UniProtKB)
TAS
GO:0005789
O15455 (UniProtKB)
TAS
GO:0005887
O15455 (UniProtKB)
TAS
GO:0006954
O15455 (UniProtKB)
IEA
GO:0006972
O15455 (UniProtKB)
NAS
GO:0007165
O15455 (UniProtKB)
TAS
GO:0007165
O15455 (UniProtKB)
TAS
GO:0007249
O15455 (UniProtKB)
TAS
GO:0007250
O15455 (UniProtKB)
NAS
GO:0007252
O15455 (UniProtKB)
IDA
GO:0008584
O15455 (UniProtKB)
IEA
GO:0009597
O15455 (UniProtKB)
NAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010008
O15455 (UniProtKB)
TAS
GO:0010628
O15455 (UniProtKB)
IMP
GO:0010628
O15455 (UniProtKB)
IMP
GO:0016020
O15455 (UniProtKB)
NAS
GO:0032722
O15455 (UniProtKB)
IDA
GO:0032728
O15455 (UniProtKB)
ISS
GO:0032735
O15455 (UniProtKB)
ISS
GO:0032755
O15455 (UniProtKB)
IDA
GO:0032757
O15455 (UniProtKB)
IDA
GO:0032760
O15455 (UniProtKB)
ISS
GO:0034123
O15455 (UniProtKB)
IDA
GO:0034128
O15455 (UniProtKB)
TAS
GO:0034138
O15455 (UniProtKB)
TAS
GO:0034346
O15455 (UniProtKB)
IEA
GO:0035458
O15455 (UniProtKB)
IEA
GO:0035666
O15455 (UniProtKB)
TAS
GO:0035666
O15455 (UniProtKB)
TAS
GO:0035690
O15455 (UniProtKB)
IEA
GO:0036020
O15455 (UniProtKB)
TAS
GO:0042346
O15455 (UniProtKB)
IDA
GO:0042742
O15455 (UniProtKB)
TAS
GO:0042802
O15455 (UniProtKB)
IPI
GO:0043065
O15455 (UniProtKB)
IEA
GO:0043330
O15455 (UniProtKB)
IDA
GO:0045078
O15455 (UniProtKB)
IDA
GO:0045080
O15455 (UniProtKB)
IEA
GO:0045087
O15455 (UniProtKB)
TAS
GO:0045356
O15455 (UniProtKB)
IDA
GO:0045359
O15455 (UniProtKB)
IMP
GO:0045359
O15455 (UniProtKB)
IDA
GO:0045671
O15455 (UniProtKB)
NAS
GO:0045944
O15455 (UniProtKB)
ISS
GO:0046330
O15455 (UniProtKB)
IEA
GO:0050729
O15455 (UniProtKB)
IC
GO:0051092
O15455 (UniProtKB)
IEA
GO:0051607
O15455 (UniProtKB)
TAS
GO:0070266
O15455 (UniProtKB)
TAS
GO:0071260
O15455 (UniProtKB)
IEP
GO:0071346
O15455 (UniProtKB)
IEA
GO:0071360
O15455 (UniProtKB)
IEA
GO:0097190
O15455 (UniProtKB)
TAS
GO:0097191
O15455 (UniProtKB)
IDA
GO:0097527
O15455 (UniProtKB)
IDA
GO:0009986
O15455 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 TLR3基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 2 0.24 1 1 CLINVAR_UNIPROT
Herpes encephalitis 0.123528744 13 0 BeFree_CTD_human
Macular Degeneration, Age-Related, 1 0.12 0 0 CTD_human
Asthma 0.083181358 5 0 BeFree_GAD_RGD
Pre-Eclampsia 0.082367032 2 0 GAD_RGD
Pancreatitis 0.080271442 2 1 BeFree_RGD
Somatosensory Disorders 0.08 1 0 RGD
Necrotizing Enterocolitis 0.08 1 0 RGD
Reperfusion Injury 0.08 1 0 RGD
Colitis 0.08 1 0 RGD

基因相关服务

基因相关服务

联系方式

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