TLR2 (toll like receptor 2)

基因基本信息

基因基本信息

symbol:
TLR2
locus group:
protein-coding gene
location:
4q31.3
gene_family:
CD molecules
alias symbol:
TIL4|CD282
alias name:
None
entrez id:
7097
ensembl gene id:
ENSG00000137462
ucsc gene id:
uc063aif.1
refseq accession:
NM_001318787
hgnc_id:
HGNC:11848
approved reserved:
1998-06-25

基因染色体位置

基因染色体位置

4q31.3
基因染色体位置图

基因简述

基因简述

TLR2（Toll样受体2，Toll-like receptor 2）是一种模式识别受体（PRR，pattern recognition receptor），属于TLR基因家族。该家族共有10个成员（TLR1-TLR10），均通过识别病原体相关分子模式（PAMP，pathogen-associated molecular patterns）激活先天免疫反应。TLR2主要表达于免疫细胞（如巨噬细胞、树突细胞）及上皮细胞表面，通过识别细菌的脂蛋白、肽聚糖等成分触发炎症反应。其功能特点是形成异源二聚体（如与TLR1或TLR6结合）以扩大识别范围。TLR2激活后通过MyD88依赖的信号通路诱导NF-κB和促炎因子（如TNF-α、IL-6）的产生。突变可能导致免疫缺陷（如反复感染）或过度炎症（如TLR2 D299G突变与哮喘相关）。该基因与多种疾病相关：过表达可能加剧自身免疫病（类风湿关节炎）、动脉粥样硬化和败血症；低表达则增加结核病、莱姆病等感染风险。TLR2还影响肠道菌群平衡，其表达异常可能引发代谢综合征。基因家族共性包括：均含富含亮氨酸重复序列（LRR，leucine-rich repeats）的胞外域和TIR（Toll/IL-1 receptor）胞内域，通过保守信号通路调控免疫应答。

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白是Toll样受体（TLR）家族中起着病原体识别和先天免疫激活的基础性作用的成员。 Toll样受体是高度果蝇保守到人类和共享结构和功能的相似性。他们认识到是在感染剂表达的病原体相关分子模式（PAMP），并介导的生产所必需的有效免疫的发展细胞因子。各种Toll样受体表现出不同的表达模式。该基因被表达在外周血白细胞最丰富，并且介导宿主反应革兰氏阳性菌和酵母通过NF-κB的刺激ST。 [由RefSeq的，2008年7月提供]

OMIM数据库中对TLR2基因的介绍     Wikipedia数据库中对TLR2基因的介绍

基因序列

基因序列

TLR2基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

TLR2基因的碱基突变：           仅显示部分snp
rs893629       rs893630       rs970233       rs1439164       rs1595624       rs1804965       rs1816702       rs1898830       rs1898831       rs1898832       rs2083287       rs2099683       rs3804099       rs3804100       rs3840097       rs4235232       rs4315760      

基因表达

基因表达

TLR2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CACTGAAGACTTTGGAAGCTG
60
AAGGAGAGGAATTCACAGGAG
59
CACTGAAGACTTTGGAAGCTG
60
AAGGAGAGGAATTCACAGGA
58
GACTTCTCCCATTTCCGTC
58
CCAGAAGAATGAGAATGGCAG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
HIF1A
TLR2
Unknown
18159247
NFKB1
TLR2
Activation
12686724; 19779021
RELA
TLR2
Activation
12686724; 19779021
SP1
TLR2
Activation
18423053
SP1
TLR2
Unknown
18583567

基因本体信息

TLR2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

TLR2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001530
O60603 (UniProtKB)
IDA
GO:0001875
O60603 (UniProtKB)
TAS
GO:0002374
O60603 (UniProtKB)
IMP
GO:0002755
O60603 (UniProtKB)
TAS
GO:0004872
O60603 (UniProtKB)
IDA
GO:0004888
O60603 (UniProtKB)
IEA
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005515
O60603 (UniProtKB)
IPI
GO:0005737
O60603 (UniProtKB)
IDA
GO:0005794
O60603 (UniProtKB)
IDA
GO:0005886
O60603 (UniProtKB)
IDA
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005886
O60603 (UniProtKB)
TAS
GO:0005887
O60603 (UniProtKB)
TAS
GO:0006915
O60603 (UniProtKB)
TAS
GO:0006954
O60603 (UniProtKB)
IEA
GO:0006955
O60603 (UniProtKB)
TAS
GO:0007165
O60603 (UniProtKB)
TAS
GO:0007252
O60603 (UniProtKB)
IDA
GO:0008329
O60603 (UniProtKB)
IDA
GO:0009986
O60603 (UniProtKB)
IDA
GO:0010628
O60603 (UniProtKB)
IMP
GO:0030177
O60603 (UniProtKB)
IMP
GO:0030670
O60603 (UniProtKB)
IEA
GO:0031226
O60603 (UniProtKB)
IDA
GO:0031663
O60603 (UniProtKB)
IEA
GO:0032613
O60603 (UniProtKB)
IDA
GO:0032722
O60603 (UniProtKB)
IDA
GO:0032728
O60603 (UniProtKB)
ISS
GO:0032735
O60603 (UniProtKB)
ISS
GO:0032741
O60603 (UniProtKB)
ISS
GO:0032755
O60603 (UniProtKB)
IDA
GO:0032757
O60603 (UniProtKB)
IDA
GO:0032757
O60603 (UniProtKB)
IDA
GO:0032760
O60603 (UniProtKB)
ISS
GO:0034123
O60603 (UniProtKB)
IDA
GO:0034134
O60603 (UniProtKB)
IEA
GO:0035325
O60603 (UniProtKB)
IPI
GO:0035354
O60603 (UniProtKB)
IDA
GO:0038123
O60603 (UniProtKB)
TAS
GO:0038124
O60603 (UniProtKB)
TAS
GO:0042346
O60603 (UniProtKB)
IDA
GO:0042495
O60603 (UniProtKB)
IDA
GO:0042496
O60603 (UniProtKB)
IDA
GO:0042497
O60603 (UniProtKB)
IDA
GO:0042834
O60603 (UniProtKB)
IDA
GO:0045087
O60603 (UniProtKB)
TAS
GO:0045121
O60603 (UniProtKB)
IDA
GO:0045944
O60603 (UniProtKB)
ISS
GO:0046982
O60603 (UniProtKB)
IDA
GO:0050707
O60603 (UniProtKB)
IEA
GO:0050729
O60603 (UniProtKB)
IC
GO:0050830
O60603 (UniProtKB)
IDA
GO:0051092
O60603 (UniProtKB)
IDA
GO:0051092
O60603 (UniProtKB)
IDA
GO:0051770
O60603 (UniProtKB)
ISS
GO:0071221
O60603 (UniProtKB)
TAS
GO:0071223
O60603 (UniProtKB)
IDA
GO:0071726
O60603 (UniProtKB)
IDA
GO:0071726
O60603 (UniProtKB)
IDA
GO:0071727
O60603 (UniProtKB)
IDA
GO:0071727
O60603 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 TLR2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Inflammation 0.221080165 10 0 CTD_human_GAD_LHGDN_RGD
Keratitis 0.201085767 6 0 BeFree_CTD_human_RGD
Reperfusion Injury 0.2 2 0 CTD_human_RGD
Rheumatoid Arthritis 0.138250076 25 1 BeFree_CTD_human_GAD_LHGDN
Leprosy 0.131639663 10 1 BeFree_CTD_human_GAD
Staphylococcal Infections 0.125276948 3 1 BeFree_CTD_human_GAD
Colorectal Neoplasms 0.122995792 3 0 BeFree_CTD_human_LHGDN
Cardiomyopathies 0.12 1 0 CTD_human
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) 0.12 0 1 CLINVAR
Eye Infections, Bacterial 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

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