TIMELESS (timeless circadian regulator)
- symbol:
- TIMELESS
- locus group:
- protein-coding gene
- location:
- 12q13.3
- gene_family:
- alias symbol:
- hTIM|TIM|TIM1
- alias name:
- Tof1 homolog (S. cerevisiae)|timel…
- entrez id:
- 8914
- ensembl gene id:
- ENSG00000111602
- ucsc gene id:
- uc001slf.3
- refseq accession:
- NM_003920
- hgnc_id:
- HGNC:11813
- approved reserved:
- 1999-01-08
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]
由该基因编码的蛋白质是高度保守的和损坏或应力，增加DNA聚合酶小量活性，端粒长度的维护，和上皮细胞形态后参与细胞存活。该编码的蛋白也起着昼夜节律自动调节循环的作用，与PERIOD基因（PER1，PER2，和PER3）和其他交互由CLOCK / ARNTL下调PER1的激活。在该基因或其表达改变可能促进前列腺癌，肺癌，乳腺癌，和精神障碍。 [由RefSeq的，2014年2月提供]
基因本体信息
TIMELESS基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
TIMELESS基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Asthma | 0.008338753 | 22 | 0 | BeFree_GAD |
| Bipolar Disorder | 0.008186863 | 7 | 0 | BeFree_GAD |
| Rheumatoid Arthritis | 0.006091273 | 5 | 0 | BeFree_GAD |
| Mammary Neoplasms | 0.003538676 | 3 | 0 | BeFree_LHGDN |
| Mental Depression | 0.002909916 | 3 | 0 | BeFree_GAD |
| Schizophrenia | 0.002638474 | 2 | 0 | BeFree_GAD |
| Malignant neoplasm of prostate | 0.002367032 | 1 | 0 | GAD |
| Metabolic Syndrome X | 0.002367032 | 1 | 0 | GAD |
| Atopy | 0.002367032 | 1 | 0 | GAD |
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