THBS4 (thrombospondin 4)

基因基本信息

基因基本信息

symbol:
THBS4
locus group:
protein-coding gene
location:
5q14.1
gene_family:
alias symbol:
None
alias name:
None
entrez id:
7060
ensembl gene id:
ENSG00000113296
ucsc gene id:
uc021yaw.2
refseq accession:
NM_001306212
hgnc_id:
HGNC:11788
approved reserved:
1995-05-17

基因染色体位置

基因染色体位置

5q14.1
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

None

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

THBS4基因的碱基突变：           仅显示部分snp
rs256437       rs256438       rs256439       rs365384       rs384941       rs394947       rs443095       rs1049798       rs1130758       rs1465853       rs2229396       rs2229398       rs2241824       rs2288394       rs2288395       rs2434300       rs2434301      

基因表达

基因表达

THBS4基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTGTGGAGTTTCTTTGACCT
58
TAGAGATCATTCAGGGCGG
59
GACGGAGCAGACATATTGG
58
CTTAGACTTCACAGCCTTGAG
59
AGTATCGCTGCAATGACAC
58
CTTGGTTTAATTATCGAAGCGG
58
TTAAACAAAGCCATCCTCCG
59
AAATTGCTCAGCCTCAGGA
59
CAAGGATGGTGATGGTGTG
59
TCATTATCCACATCAGACTGGT
59
AACTCTTAGGAGCAGCTTGG
60
AGGTCAAAGAGATCATGGTGG
60
CAAGGATGGTGATGGTGTG
59
TCATTATCCACATCAGACTGGT
59
CAGGACAGTGGAATTGTTCTG
59
TGAGTCTTAATGTGGGACTCC
59
GACGGAGCAGACATATTGG
58
CTTAGACTTCACAGCCTTGAG
59
ACTCTTAGGAGCAGCTTGG
59
AGGTCAAAGAGATCATGGTGG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

THBS4基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

THBS4基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005509
E7ES19 (UniProtKB)
IEA
GO:0005576
E7ES19 (UniProtKB)
IEA
GO:0007155
E7ES19 (UniProtKB)
IEA
GO:0001938
P35443 (UniProtKB)
IDA
GO:0001968
P35443 (UniProtKB)
IEA
GO:0005178
P35443 (UniProtKB)
IDA
GO:0005509
P35443 (UniProtKB)
IDA
GO:0005509
P35443 (UniProtKB)
IDA
GO:0005515
P35443 (UniProtKB)
IPI
GO:0005518
P35443 (UniProtKB)
IEA
GO:0005576
P35443 (UniProtKB)
TAS
GO:0005604
P35443 (UniProtKB)
IDA
GO:0005615
P35443 (UniProtKB)
IDA
GO:0005615
P35443 (UniProtKB)
IDA
GO:0005783
P35443 (UniProtKB)
ISS
GO:0006986
P35443 (UniProtKB)
IEA
GO:0008083
P35443 (UniProtKB)
IEA
GO:0008201
P35443 (UniProtKB)
IDA
GO:0016525
P35443 (UniProtKB)
IEP
GO:0016529
P35443 (UniProtKB)
ISS
GO:0031012
P35443 (UniProtKB)
ISS
GO:0031594
P35443 (UniProtKB)
IEA
GO:0034103
P35443 (UniProtKB)
ISS
GO:0034976
P35443 (UniProtKB)
ISS
GO:0043237
P35443 (UniProtKB)
IEA
GO:0048266
P35443 (UniProtKB)
ISS
GO:0048771
P35443 (UniProtKB)
IEA
GO:0048812
P35443 (UniProtKB)
IEA
GO:0050731
P35443 (UniProtKB)
IDA
GO:0051260
P35443 (UniProtKB)
IEA
GO:0051451
P35443 (UniProtKB)
IDA
GO:0051781
P35443 (UniProtKB)
IEA
GO:0070062
P35443 (UniProtKB)
IDA
GO:0071603
P35443 (UniProtKB)
IDA
GO:0090023
P35443 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 THBS4基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

BioGrid

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Myocardial Infarction 0.013278246 5 2 BeFree_GAD_LHGDN
Lymphoma, T-Cell, Cutaneous 0.00272435 1 0 LHGDN
Atherosclerosis 0.002638474 2 1 BeFree_GAD
Fetal Membranes, Premature Rupture 0.002367032 1 0 GAD
Premature Obstetric Labor 0.002367032 1 0 GAD
Pre-Eclampsia 0.002367032 1 0 GAD
Maduromycosis 0.002367032 1 0 GAD
Coronary Arteriosclerosis 0.002367032 1 0 GAD
Myocardial Ischemia 0.002367032 1 0 GAD
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified 0.002367032 1 0 GAD

基因相关服务

基因相关服务

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