TCIM (transcriptional and immune response regulator)
- symbol:
- TCIM
- locus group:
- protein-coding gene
- location:
- 8p11.21
- gene_family:
- alias symbol:
- TC-1|hTC-1|TC1
- alias name:
- human thyroid cancer 1
- entrez id:
- 56892
- ensembl gene id:
- ENSG00000176907
- ucsc gene id:
- uc003xnq.3
- refseq accession:
- NM_020130
- hgnc_id:
- HGNC:1357
- approved reserved:
- 2000-07-12
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
这个基因编码的小，单体，主要是非结构化蛋白，其功能如同所述的Wnt /β-连环蛋白信号传导途径的正调节。这种蛋白质与核斑点β-连环蛋白介导的转录的阻抑相互作用。它被认为是竞争性地阻断与β-连环蛋白的阻抑物的相互作用，导致β-连环蛋白靶基因的上调。所编码的蛋白质也可在NF-κB的发挥作用和ERK1 / 2信号途径。这个基因的表达可能在几种类型的癌症，包括甲状腺癌，乳腺癌和恶性血液病的增殖的作用。 [由RefSeq的，2011年11月提供]
基因本体信息
TCIM基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
TCIM基因的本体（GO）信息：
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