TCF7L2 (transcription factor 7 like 2)

基因基本信息

基因基本信息

symbol:
TCF7L2
locus group:
protein-coding gene
location:
10q25.2-q25.3
gene_family:
alias symbol:
TCF-4
alias name:
None
entrez id:
6934
ensembl gene id:
ENSG00000148737
ucsc gene id:
uc001lac.5
refseq accession:
NM_030756
hgnc_id:
HGNC:11641
approved reserved:
1998-01-20

基因染色体位置

基因染色体位置

10q25.2-q25.3
基因染色体位置图

基因简述

基因简述

TCF7L2（转录因子7类似物2，英文全称Transcription Factor 7-Like 2）属于TCF/LEF基因家族，该家族成员均为Wnt信号通路的关键转录调控因子，其共性是依赖β-连环蛋白（β-catenin）激活下游靶基因表达，参与胚胎发育、细胞增殖分化等过程。TCF7L2编码的蛋白质含有高迁移率族（HMG）结构域，可特异性结合DNA调控区域，主要在小肠、肝脏、胰腺和脂肪组织表达，其核心功能是调节胰岛素分泌和糖代谢稳态。该基因的常见突变（如rs7903146）会显著降低胰腺β细胞功能，导致胰岛素分泌不足，成为2型糖尿病最强的遗传风险因素之一，携带风险等位基因者患病概率增加1.4-1.6倍。突变还可能影响Wnt信号传导效率，导致肠内分泌细胞分化异常。当TCF7L2过表达时，会异常激活Wnt靶基因如c-Myc、Cyclin D1，促进细胞过度增殖，与结直肠癌发生相关；而表达降低则损害胰岛β细胞增殖能力，减少胰高血糖素样肽-1（GLP-1）的合成，削弱肠促胰岛素效应。该基因还通过表观遗传调控影响其他代谢相关基因（如GCK、IRS1）的表达，其单核苷酸多态性（SNP）与妊娠糖尿病和肥胖易感性也存在关联。药物研发中针对TCF7L2相关通路（如DPP-4抑制剂）已成为糖尿病治疗的重要策略。

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

此基因编码起着Wnt信号途径中的关键作用，高迁移率组（HMG）含盒转录因子。蛋白质有牵连的血糖稳态。该基因的遗传变异与II型糖尿病的风险增加有关。一些转录变异体编码多种不同的亚型已经发现了这种基因。[由RefSeq的，2010年10月提供]

OMIM数据库中对TCF7L2基因的介绍     Wikipedia数据库中对TCF7L2基因的介绍

基因序列

基因序列

TCF7L2基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

TCF7L2基因的碱基突变：           仅显示部分snp
rs2094405       rs2094406       rs2094407       rs2104597       rs2104598       rs5787982       rs6585194       rs7079073       rs7094463       rs7094871       rs7909016       rs10711698       rs10885396       rs10885397       rs10885398       rs11196168       rs11814830      

基因表达

基因表达

TCF7L2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CGAAATACTACGAGCTGGC
58
CTTCTTTCCATAGTTATCCCGC
59
AGAGACCAATGAACACAGC
57
ATTTCTTAGGAGCGCTCAG
57
AGATTGCAGTTCAGTATCTCC
57
TGAGGGCTTGTCTACTCTG
58
ACATTGTCTCTAACAAAGTGCC
59
TCATTGCTGTACGTGATAAGAG
58
AAAGTTTGGAAGAAGCGGC
59
CAGTGGCCATTTCATCTGG
58
GAAATACTACGAGCTGGCC
58
CTTCTTTCCATAGTTATCCCGC
59
AGACCAATGAACACAGCGA
59
CATTTCTTAGGAGCGCTCAG
58
CACATTGTCTCTAACAAAGTGC
58
ATTGCTGTACGTGATAAGAGG
58
AGATTGCAGTTCAGTATCTCCA
59
TGAGGGCTTGTCTACTCTG
58
AAAGTTTGGAAGAAGCGGC
59
AGTGGCCATTTCATCTGGA
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
AR
TCF7L2
Unknown
12799378
FOXA2
TCF7L2
Unknown
22951069
GATA3
TCF7L2
Unknown
22951069
HNF4A
TCF7L2
Unknown
22951069
TCF7L2
ABCB1
Unknown
10987283
TCF7L2
ACVRL1
Unknown
20803090
TCF7L2
BIRC5
Activation
20331626
TCF7L2
CTNNB1
Unknown
24317174
TCF7L2
GATA3
Unknown
22951069
TCF7L2
GLCE
Unknown
15853773; 22805760

基因本体信息

TCF7L2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

TCF7L2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005634
A0A0A0MTL7 (UniProtKB)
IEA
GO:0006357
A0A0A0MTL7 (UniProtKB)
IEA
GO:0008013
A0A0A0MTL7 (UniProtKB)
IEA
GO:0060070
A0A0A0MTL7 (UniProtKB)
IEA
GO:2001237
A0A0A0MTL7 (UniProtKB)
IEA
GO:0005634
A0A0D9SGH8 (UniProtKB)
IEA
GO:0006357
A0A0D9SGH8 (UniProtKB)
IEA
GO:0008013
A0A0D9SGH8 (UniProtKB)
IEA
GO:0060070
A0A0D9SGH8 (UniProtKB)
IEA
GO:2001237
A0A0D9SGH8 (UniProtKB)
IEA
GO:0005654
C6ZRJ6 (UniProtKB)
IDA
GO:0005737
C6ZRJ6 (UniProtKB)
IDA
GO:0006357
C6ZRJ6 (UniProtKB)
IEA
GO:0008013
C6ZRJ6 (UniProtKB)
IEA
GO:0060070
C6ZRJ6 (UniProtKB)
IEA
GO:2001237
C6ZRJ6 (UniProtKB)
IEA
GO:0005634
C6ZRJ7 (UniProtKB)
IEA
GO:0006357
C6ZRJ7 (UniProtKB)
IEA
GO:0008013
C6ZRJ7 (UniProtKB)
IEA
GO:0060070
C6ZRJ7 (UniProtKB)
IEA
GO:2001237
C6ZRJ7 (UniProtKB)
IEA
GO:0005654
C6ZRK5 (UniProtKB)
IDA
GO:0005737
C6ZRK5 (UniProtKB)
IDA
GO:0006357
C6ZRK5 (UniProtKB)
IEA
GO:0008013
C6ZRK5 (UniProtKB)
IEA
GO:0060070
C6ZRK5 (UniProtKB)
IEA
GO:2001237
C6ZRK5 (UniProtKB)
IEA
GO:0005654
E2GH26 (UniProtKB)
IDA
GO:0005737
E2GH26 (UniProtKB)
IDA
GO:0006357
E2GH26 (UniProtKB)
IEA
GO:0008013
E2GH26 (UniProtKB)
IEA
GO:0060070
E2GH26 (UniProtKB)
IEA
GO:2001237
E2GH26 (UniProtKB)
IEA
GO:0016055
H0YEE5 (UniProtKB)
IEA
GO:0016055
Q5JRY3 (UniProtKB)
IEA
GO:0016055
Q5JRY4 (UniProtKB)
IEA
GO:0005634
Q5JRY5 (UniProtKB)
IEA
GO:0006357
Q5JRY5 (UniProtKB)
IEA
GO:0008013
Q5JRY5 (UniProtKB)
IEA
GO:0060070
Q5JRY5 (UniProtKB)
IEA
GO:2001237
Q5JRY5 (UniProtKB)
IEA
GO:0005634
Q5VVR5 (UniProtKB)
IEA
GO:0006357
Q5VVR5 (UniProtKB)
IEA
GO:0008013
Q5VVR5 (UniProtKB)
IEA
GO:0060070
Q5VVR5 (UniProtKB)
IEA
GO:2001237
Q5VVR5 (UniProtKB)
IEA
GO:0005634
Q5VVR7 (UniProtKB)
IEA
GO:0006357
Q5VVR7 (UniProtKB)
IEA
GO:0008013
Q5VVR7 (UniProtKB)
IEA
GO:0060070
Q5VVR7 (UniProtKB)
IEA
GO:2001237
Q5VVR7 (UniProtKB)
IEA
GO:0005634
Q5VVR8 (UniProtKB)
IEA
GO:0006357
Q5VVR8 (UniProtKB)
IEA
GO:0008013
Q5VVR8 (UniProtKB)
IEA
GO:0060070
Q5VVR8 (UniProtKB)
IEA
GO:2001237
Q5VVR8 (UniProtKB)
IEA
GO:0000122
Q9NQB0 (UniProtKB)
IDA
GO:0000790
Q9NQB0 (UniProtKB)
IDA
GO:0000978
Q9NQB0 (UniProtKB)
IDA
GO:0001103
Q9NQB0 (UniProtKB)
IPI
GO:0001568
Q9NQB0 (UniProtKB)
IMP
GO:0003700
Q9NQB0 (UniProtKB)
IDA
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005515
Q9NQB0 (UniProtKB)
IPI
GO:0005634
Q9NQB0 (UniProtKB)
IDA
GO:0005634
Q9NQB0 (UniProtKB)
IDA
GO:0005634
Q9NQB0 (UniProtKB)
IDA
GO:0005634
Q9NQB0 (UniProtKB)
IDA
GO:0005654
Q9NQB0 (UniProtKB)
IDA
GO:0005654
Q9NQB0 (UniProtKB)
IDA
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005654
Q9NQB0 (UniProtKB)
TAS
GO:0005737
Q9NQB0 (UniProtKB)
IDA
GO:0006351
Q9NQB0 (UniProtKB)
IEA
GO:0006357
Q9NQB0 (UniProtKB)
IDA
GO:0007050
Q9NQB0 (UniProtKB)
IMP
GO:0007223
Q9NQB0 (UniProtKB)
TAS
GO:0008013
Q9NQB0 (UniProtKB)
IPI
GO:0008013
Q9NQB0 (UniProtKB)
IPI
GO:0008013
Q9NQB0 (UniProtKB)
IDA
GO:0008134
Q9NQB0 (UniProtKB)
IPI
GO:0008283
Q9NQB0 (UniProtKB)
IMP
GO:0009749
Q9NQB0 (UniProtKB)
ISS
GO:0010909
Q9NQB0 (UniProtKB)
IMP
GO:0016605
Q9NQB0 (UniProtKB)
IEA
GO:0019901
Q9NQB0 (UniProtKB)
IPI
GO:0031016
Q9NQB0 (UniProtKB)
TAS
GO:0032024
Q9NQB0 (UniProtKB)
IDA
GO:0032024
Q9NQB0 (UniProtKB)
IMP
GO:0032092
Q9NQB0 (UniProtKB)
IDA
GO:0032350
Q9NQB0 (UniProtKB)
IDA
GO:0032993
Q9NQB0 (UniProtKB)
IDA
GO:0035257
Q9NQB0 (UniProtKB)
IPI
GO:0042593
Q9NQB0 (UniProtKB)
IDA
GO:0043433
Q9NQB0 (UniProtKB)
IDA
GO:0043565
Q9NQB0 (UniProtKB)
IDA
GO:0043565
Q9NQB0 (UniProtKB)
IMP
GO:0043570
Q9NQB0 (UniProtKB)
IMP
GO:0044212
Q9NQB0 (UniProtKB)
IDA
GO:0044334
Q9NQB0 (UniProtKB)
IMP
GO:0045295
Q9NQB0 (UniProtKB)
IPI
GO:0045444
Q9NQB0 (UniProtKB)
IDA
GO:0045892
Q9NQB0 (UniProtKB)
IDA
GO:0045892
Q9NQB0 (UniProtKB)
IDA
GO:0045892
Q9NQB0 (UniProtKB)
IMP
GO:0045944
Q9NQB0 (UniProtKB)
IDA
GO:0045944
Q9NQB0 (UniProtKB)
IDA
GO:0046827
Q9NQB0 (UniProtKB)
IMP
GO:0048625
Q9NQB0 (UniProtKB)
IDA
GO:0048660
Q9NQB0 (UniProtKB)
IMP
GO:0051897
Q9NQB0 (UniProtKB)
IMP
GO:0060070
Q9NQB0 (UniProtKB)
IC
GO:0070016
Q9NQB0 (UniProtKB)
IPI
GO:0070369
Q9NQB0 (UniProtKB)
IDA
GO:0070369
Q9NQB0 (UniProtKB)
IDA
GO:0090090
Q9NQB0 (UniProtKB)
IMP
GO:1904837
Q9NQB0 (UniProtKB)
TAS
GO:2000675
Q9NQB0 (UniProtKB)
IDA
GO:2001237
Q9NQB0 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 TCF7L2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Diabetes Mellitus, Non-Insulin-Dependent 0.613988408 328 54 BeFree_CLINVAR_CTD_human_GAD_GWASCAT_LHGDN_RGD
Colorectal Neoplasms 0.138789078 16 3 BeFree_CTD_human_LHGDN
Colorectal Cancer 0.135863181 43 6 BeFree_GAD_GWASCAT
Colonic Neoplasms 0.133178557 5 0 BeFree_CTD_human_GAD_LHGDN
Metabolic Syndrome X 0.129001189 10 7 BeFree_GAD_GWASCAT
Malignant neoplasm of breast 0.126710102 18 6 BeFree_GAD_GWASCAT
Adenocarcinoma 0.120542884 3 0 BeFree_CTD_human
Bipolar Disorder 0.120542884 2 2 BeFree_GWASCAT
Hyperplasia 0.12 1 0 CTD_human
Juvenile arthritis 0.12 1 0 CTD_human

基因相关服务

基因相关服务

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