STEAP2 (STEAP2 metalloreductase)
- symbol:
- STEAP2
- locus group:
- protein-coding gene
- location:
- 7q21.13
- gene_family:
- alias symbol:
- IPCA-1|STAMP1|STMP
- alias name:
- None
- entrez id:
- 261729
- ensembl gene id:
- ENSG00000157214
- ucsc gene id:
- uc010len.3
- refseq accession:
- NM_152999
- hgnc_id:
- HGNC:17885
- approved reserved:
- 2002-09-12
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
此基因是STEAP家族的成员，并且编码与定位于高尔基复合体，质膜，并且在细胞质囊泡管状结构的多遍膜蛋白。在小鼠高度类似蛋白具有两个ferrireductase和铜还原酶活性，和刺激体外铁和铜的细胞摄取。人类基因的增加的转录表达与前列腺癌的进展有关。备用转录剪接变体，编码不同同种型，已经表征。 [由RefSeq的，2008年7月提供]
基因本体信息
STEAP2基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
STEAP2基因的本体（GO）信息：
| 名称 |
|---|
| 4978 Mineral absorption [PATH:hsa04978] |
| 名称 |
|---|
| Iron uptake and transport |
| Transferrin endocytosis and recycling |
| Transmembrane transport of small molecules |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Prostatic Neoplasms | 0.008444493 | 3 | 0 | BeFree_LHGDN |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
| Prostate carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
| Ewings sarcoma | 0.000271442 | 1 | 0 | BeFree |
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