STAT3 (signal transducer and activator of transcription 3)

基因基本信息

基因基本信息

symbol:
STAT3
locus group:
protein-coding gene
location:
17q21.2
gene_family:
SH2 domain containing
alias symbol:
APRF
alias name:
None
entrez id:
6774
ensembl gene id:
ENSG00000168610
ucsc gene id:
uc002hzl.2
refseq accession:
NM_139276|NM_003150
hgnc_id:
HGNC:11364
approved reserved:
1995-11-08

基因染色体位置

基因染色体位置

17q21.2
基因染色体位置图

基因简述

基因简述

STAT3（信号转导和转录激活因子3，Signal Transducer and Activator of Transcription 3）是一种重要的转录因子，属于STAT蛋白家族。该家族共有7个成员（STAT1-4、5A、5B、6），它们共同的特点是能够被细胞因子或生长因子激活，通过JAK（Janus激酶）介导的磷酸化形成二聚体并转入细胞核，调控靶基因的转录。STAT3在多种细胞过程中发挥关键作用，包括细胞增殖、存活、分化、免疫调节和炎症反应。其主要作用位点是细胞质，在被激活后转移至细胞核内结合DNA。STAT3的突变可能导致功能异常，例如组成性激活（持续激活）的STAT3与多种癌症（如乳腺癌、肺癌、血液系统恶性肿瘤）密切相关，而功能丧失性突变则可能引起免疫缺陷或发育异常。STAT3的过表达通常促进肿瘤发生，因为它能上调抗凋亡基因（如Bcl-2）和细胞周期调控基因（如Cyclin D1），同时抑制免疫监视。相反，STAT3表达降低可能影响Th17细胞分化，导致免疫失调，并与某些自身免疫性疾病（如多发性硬化）相关。STAT3还参与IL-6家族细胞因子的信号传导，在慢性炎症和癌症微环境中起重要作用。此外，STAT3的活性受多种调控机制影响，包括表观遗传修饰、microRNA调控和蛋白降解途径。在药物开发中，STAT3抑制剂被研究用于癌症治疗，但由于其广泛生理功能，靶向抑制需谨慎以避免严重副作用。

None

无

OMIM数据库中对STAT3基因的介绍     Wikipedia数据库中对STAT3基因的介绍

基因序列

基因序列

STAT3基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

STAT3基因的碱基突变：           仅显示部分snp
rs10775       rs744166       rs957970       rs957971       rs1026916       rs1053004       rs1053005       rs1053023       rs1064110       rs1064112       rs1064113       rs1064114       rs1064115       rs1064116       rs1064117       rs1064118       rs1064119      

基因表达

基因表达

STAT3基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AATACCATTGACCTGCCGA
59
AGGTGAGGGACTCAAACTG
59
AAACTCTTGGGACCTGGTG
60
CAGACCCAGAAGGAGAAGC
60
AAGTGGTAGAGAATCTCCAGG
59
CATTCAGATCTTGCATGTCTCC
60
GTGCATTGACAAAGACTCTG
57
GGATGAAGTTAGGTTAAACGGA
58
GAAAGTATTGTCGGCCAGAG
59
CATCAATGAATGGTGTCACAC
58
AGAAACTCTTGGGACCTGG
59
AGGTGAGCATTCCCATTCC
60
AAACAGTAGATCAAGGGCAG
58
GCTCCATGTTTACAGAAGCTC
59
ATCAGCTCTACAGTGACAGC
60
GCATATGCCCAATCTTGACTC
60
ATCAGCTCTACAGTGACAGC
60
GCATATGCCCAATCTTGACTC
60
AGCCATTGCATTTACTGGA
57
CAATTGGTTCATTCCGTCCT
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
BCL6
STAT3
Unknown
17951530
BRCA1
STAT3
Unknown
11163768
CEBPA
STAT3
Unknown
24429361
HDAC1
STAT3
Unknown
18611949
HIC1
STAT3
Activation
24067369
HIF1A
STAT3
Unknown
23991099
KAT5
STAT3
Repression
12551922
PIAS3
STAT3
Unknown
16098628
RELA
STAT3
Unknown
25040843
SPI1
STAT3
Unknown
24429361

基因本体信息

STAT3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

STAT3基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003677
G8JLH9 (UniProtKB)
IEA
GO:0003700
G8JLH9 (UniProtKB)
IEA
GO:0004871
G8JLH9 (UniProtKB)
IEA
GO:0005654
G8JLH9 (UniProtKB)
IDA
GO:0005737
G8JLH9 (UniProtKB)
IDA
GO:0006351
G8JLH9 (UniProtKB)
IEA
GO:0006355
G8JLH9 (UniProtKB)
IEA
GO:0007165
G8JLH9 (UniProtKB)
IEA
GO:0003700
K7EP08 (UniProtKB)
IEA
GO:0004871
K7EP08 (UniProtKB)
IEA
GO:0005634
K7EP08 (UniProtKB)
IEA
GO:0006355
K7EP08 (UniProtKB)
IEA
GO:0007165
K7EP08 (UniProtKB)
IEA
GO:0000122
P40763 (UniProtKB)
TAS
GO:0000790
P40763 (UniProtKB)
IDA
GO:0000978
P40763 (UniProtKB)
IDA
GO:0000978
P40763 (UniProtKB)
IDA
GO:0001077
P40763 (UniProtKB)
IMP
GO:0001103
P40763 (UniProtKB)
IPI
GO:0001228
P40763 (UniProtKB)
IDA
GO:0001659
P40763 (UniProtKB)
ISS
GO:0001754
P40763 (UniProtKB)
ISS
GO:0003677
P40763 (UniProtKB)
ISS
GO:0003700
P40763 (UniProtKB)
IDA
GO:0004871
P40763 (UniProtKB)
TAS
GO:0004879
P40763 (UniProtKB)
IDA
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005515
P40763 (UniProtKB)
IPI
GO:0005634
P40763 (UniProtKB)
ISS
GO:0005634
P40763 (UniProtKB)
IDA
GO:0005634
P40763 (UniProtKB)
IDA
GO:0005634
P40763 (UniProtKB)
IDA
GO:0005634
P40763 (UniProtKB)
IDA
GO:0005634
P40763 (UniProtKB)
IDA
GO:0005654
P40763 (UniProtKB)
IDA
GO:0005654
P40763 (UniProtKB)
TAS
GO:0005654
P40763 (UniProtKB)
TAS
GO:0005654
P40763 (UniProtKB)
TAS
GO:0005654
P40763 (UniProtKB)
TAS
GO:0005737
P40763 (UniProtKB)
ISS
GO:0005737
P40763 (UniProtKB)
IDA
GO:0005737
P40763 (UniProtKB)
IDA
GO:0005737
P40763 (UniProtKB)
IDA
GO:0005743
P40763 (UniProtKB)
IEA
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005829
P40763 (UniProtKB)
TAS
GO:0005886
P40763 (UniProtKB)
ISS
GO:0006355
P40763 (UniProtKB)
IDA
GO:0006355
P40763 (UniProtKB)
IDA
GO:0006357
P40763 (UniProtKB)
ISS
GO:0006366
P40763 (UniProtKB)
IEA
GO:0006606
P40763 (UniProtKB)
IDA
GO:0006928
P40763 (UniProtKB)
TAS
GO:0006953
P40763 (UniProtKB)
IEA
GO:0007165
P40763 (UniProtKB)
TAS
GO:0007165
P40763 (UniProtKB)
TAS
GO:0007259
P40763 (UniProtKB)
TAS
GO:0007399
P40763 (UniProtKB)
TAS
GO:0007568
P40763 (UniProtKB)
IEA
GO:0008134
P40763 (UniProtKB)
IPI
GO:0008283
P40763 (UniProtKB)
IEA
GO:0008285
P40763 (UniProtKB)
IEA
GO:0010628
P40763 (UniProtKB)
IDA
GO:0010628
P40763 (UniProtKB)
IMP
GO:0010730
P40763 (UniProtKB)
IEA
GO:0016032
P40763 (UniProtKB)
IEA
GO:0016310
P40763 (UniProtKB)
ISS
GO:0019221
P40763 (UniProtKB)
NAS
GO:0019901
P40763 (UniProtKB)
ISS
GO:0019903
P40763 (UniProtKB)
IPI
GO:0019953
P40763 (UniProtKB)
ISS
GO:0030522
P40763 (UniProtKB)
IDA
GO:0031490
P40763 (UniProtKB)
IDA
GO:0031730
P40763 (UniProtKB)
IEA
GO:0032355
P40763 (UniProtKB)
IDA
GO:0032870
P40763 (UniProtKB)
IDA
GO:0033210
P40763 (UniProtKB)
IDA
GO:0035019
P40763 (UniProtKB)
TAS
GO:0035259
P40763 (UniProtKB)
IEA
GO:0035278
P40763 (UniProtKB)
IDA
GO:0040014
P40763 (UniProtKB)
IEA
GO:0042493
P40763 (UniProtKB)
IEA
GO:0042517
P40763 (UniProtKB)
TAS
GO:0042593
P40763 (UniProtKB)
ISS
GO:0042755
P40763 (UniProtKB)
ISS
GO:0042802
P40763 (UniProtKB)
IPI
GO:0042802
P40763 (UniProtKB)
IPI
GO:0042802
P40763 (UniProtKB)
IPI
GO:0043066
P40763 (UniProtKB)
IMP
GO:0044212
P40763 (UniProtKB)
IDA
GO:0044320
P40763 (UniProtKB)
IDA
GO:0044321
P40763 (UniProtKB)
IDA
GO:0045471
P40763 (UniProtKB)
IEA
GO:0045747
P40763 (UniProtKB)
ISS
GO:0045820
P40763 (UniProtKB)
IEA
GO:0045893
P40763 (UniProtKB)
ISS
GO:0045893
P40763 (UniProtKB)
IDA
GO:0045893
P40763 (UniProtKB)
IMP
GO:0045944
P40763 (UniProtKB)
IMP
GO:0045944
P40763 (UniProtKB)
IMP
GO:0045944
P40763 (UniProtKB)
IDA
GO:0045944
P40763 (UniProtKB)
IGI
GO:0046902
P40763 (UniProtKB)
IEA
GO:0046983
P40763 (UniProtKB)
ISS
GO:0048708
P40763 (UniProtKB)
ISS
GO:0051726
P40763 (UniProtKB)
IDA
GO:0060019
P40763 (UniProtKB)
ISS
GO:0060259
P40763 (UniProtKB)
ISS
GO:0060396
P40763 (UniProtKB)
IDA
GO:0060397
P40763 (UniProtKB)
ISS
GO:0060397
P40763 (UniProtKB)
IDA
GO:0070102
P40763 (UniProtKB)
IDA
GO:0070102
P40763 (UniProtKB)
IDA
GO:0070102
P40763 (UniProtKB)
IMP
GO:0070102
P40763 (UniProtKB)
IMP
GO:0070102
P40763 (UniProtKB)
IDA
GO:0071407
P40763 (UniProtKB)
IEA
GO:0090575
P40763 (UniProtKB)
IC
GO:0090575
P40763 (UniProtKB)
IMP
GO:0097009
P40763 (UniProtKB)
ISS
GO:1901215
P40763 (UniProtKB)
IEA
GO:1902728
P40763 (UniProtKB)
IEA
GO:1902895
P40763 (UniProtKB)
IDA
GO:1902895
P40763 (UniProtKB)
IDA
GO:1904685
P40763 (UniProtKB)
IGI
GO:2000637
P40763 (UniProtKB)
IDA
GO:2001171
P40763 (UniProtKB)
IEA
GO:2001223
P40763 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 STAT3基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant 0.44 2 0 CTD_human_MGD_ORPHANET_UNIPROT
Arthritis, Experimental 0.2 2 0 CTD_human_RGD
Mammary Neoplasms 0.159759623 29 0 BeFree_CTD_human_LHGDN
Neoplasm Metastasis 0.148249818 87 0 BeFree_CTD_human_LHGDN
Crohn Disease 0.146189242 26 4 BeFree_GAD_GWASCAT
Stomach Neoplasms 0.142609128 12 0 BeFree_CTD_human_LHGDN
Squamous cell carcinoma 0.142317823 29 0 BeFree_CTD_human_LHGDN
Prostatic Neoplasms 0.138246195 14 0 BeFree_CTD_human_LHGDN
Job Syndrome 0.135274147 7 0 CTD_human_GAD_LHGDN
Ulcerative Colitis 0.135254284 23 3 BeFree_CTD_human_GAD_LHGDN

基因相关服务

基因相关服务

联系方式

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