SSX2 (SSX family member 2)
- symbol:
- SSX2
- locus group:
- protein-coding gene
- location:
- Xp11.22
- gene_family:
- alias symbol:
- HOM-MEL-40|HD21|MGC3884|MGC15364|MGC119055|CT5.2a
- alias name:
- sarcoma, synovial, X-chromosome-re…
- entrez id:
- 6757
- ensembl gene id:
- ENSG00000241476
- ucsc gene id:
- uc004dqz.3
- refseq accession:
- NM_003147
- hgnc_id:
- HGNC:11336
- approved reserved:
- 1995-03-06
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]
该基因的产物属于家庭高度同源的滑膜肉瘤X（SSX）断点蛋白质。这些蛋白质可以充当转录抑制。它们也能够引发癌症患者自发的体液和细胞免疫应答，且是潜在的癌症基于疫苗免疫治疗的目标。这种基因，也是SSX1和SSX4家庭成员，曾参与T（X; 18）（P11.2; q11.2）易位了在所有的滑膜肉瘤特征性发现。这种易位导致18号染色体上的滑膜肉瘤易位基因融合到SSX基因之一在染色体X的编码杂合蛋白是用于转化的活性可能负责。这个基因的选择性剪接的结果在多个转录变体。该基因也具有相同的重复，GeneID：727837，相距约45 kb的下游在X染色体相反方向[由RefSeq的，2013年7月提供]
基因本体信息
SSX2基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
SSX2基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| synovial sarcoma | 0.282646168 | 128 | 0 | BeFree_CTD_human_LHGDN_ORPHANET |
| Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
| Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Malignant neoplasm of testis | 0.005700279 | 21 | 0 | BeFree |
| Sarcoma | 0.004614512 | 17 | 0 | BeFree |
| Liver carcinoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Carcinogenesis | 0.002714419 | 10 | 0 | BeFree |
| melanoma | 0.002714419 | 10 | 0 | BeFree |
| Neoplasm Metastasis | 0.001900093 | 7 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001628651 | 6 | 0 | BeFree |
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
