SRSF1 (serine and arginine rich splicing factor 1)

基因基本信息

基因基本信息

symbol:
SRSF1
locus group:
protein-coding gene
location:
17q22
gene_family:
RNA binding motif containing|Serine/arginine-rich splicing factors
alias symbol:
ASF|SF2|SRp30a|SF2p33|MGC5228
alias name:
splicing factor 2|pre-mRNA-splicin…
entrez id:
6426
ensembl gene id:
ENSG00000136450
ucsc gene id:
uc002ivi.4
refseq accession:
NM_006924
hgnc_id:
HGNC:10780
approved reserved:
1993-09-17

基因染色体位置

基因染色体位置

17q22
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]

该基因编码精氨酸/富丝氨酸剪接因子蛋白家族中的一员。所编码的蛋白质可以激活或抑制剪接，这取决于它的磷酸化状态和其相互作用伴侣。多个抄本变形也发现了这种基因。有13对染色体该基因的假[由RefSeq的，2014年6月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

SRSF1基因的碱基突变：           仅显示部分snp
rs8819       rs10623       rs1130307       rs2233905       rs2233906       rs2233908       rs2233909       rs2233910       rs2233911       rs2233912       rs2585828       rs2585829       rs3189003       rs3189004       rs3189006       rs3760174       rs3851810      

基因表达

基因表达

SRSF1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAGGAGTCGCAGTTACTCC
60
TCTCTTCAGATATGTGAGAGCG
60
AGTGGTTGTCTCTGGACTG
59
AGCATAACATACATCACCTGC
59
AGTGGTTGTCTCTGGACTG
59
AGCATAACATACATCACCTGC
59
CTCATGAGGGAGAAACTGC
58
CTTCGAGATCGAGATCTTCC
57
CTCATGAGGGAGAAACTGC
58
CTTCGAGATCGAGATCTTCC
57
CATCGACCTCAAGAATCGC
59
TTCCGCGTCTCTATTTCCTC
60
TAATGGAGGCAATGGAGCA
59
ATCTACTCGTGCTGAATCCT
58
TTCGTTGAGTTCGAGGACC
60
CCATCGTAATCATAGCCGTC
58
AGTGGTTGTCTCTGGACTG
59
AGCATAACATACATCACCTGC
59
AACCAAGGACATTGAGGAC
57
TTCAGATATGTACCGCGTC
57

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
MYC
SRSF1
Activation
22545246
SRSF1
MYC
Unknown
22545246
SRSF1
NFKB1
Repression
19183244

基因本体信息

SRSF1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

SRSF1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000166
J3KSR8 (UniProtKB)
IEA
GO:0003676
J3KSR8 (UniProtKB)
IEA
GO:0000166
J3KSW7 (UniProtKB)
IEA
GO:0003676
J3KSW7 (UniProtKB)
IEA
GO:0000166
J3KTL2 (UniProtKB)
IEA
GO:0003676
J3KTL2 (UniProtKB)
IEA
GO:0000166
J3QQV5 (UniProtKB)
IEA
GO:0003676
J3QQV5 (UniProtKB)
IEA
GO:0000166
Q07955 (UniProtKB)
IEA
GO:0000380
Q07955 (UniProtKB)
IDA
GO:0000395
Q07955 (UniProtKB)
IDA
GO:0000395
Q07955 (UniProtKB)
IDA
GO:0000398
Q07955 (UniProtKB)
IC
GO:0000398
Q07955 (UniProtKB)
TAS
GO:0000398
Q07955 (UniProtKB)
TAS
GO:0001701
Q07955 (UniProtKB)
IEA
GO:0003723
Q07955 (UniProtKB)
IDA
GO:0003723
Q07955 (UniProtKB)
IPI
GO:0003729
Q07955 (UniProtKB)
IDA
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005515
Q07955 (UniProtKB)
IPI
GO:0005634
Q07955 (UniProtKB)
IDA
GO:0005634
Q07955 (UniProtKB)
IDA
GO:0005654
Q07955 (UniProtKB)
IDA
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005654
Q07955 (UniProtKB)
TAS
GO:0005737
Q07955 (UniProtKB)
IEA
GO:0006369
Q07955 (UniProtKB)
TAS
GO:0006376
Q07955 (UniProtKB)
TAS
GO:0006397
Q07955 (UniProtKB)
TAS
GO:0006405
Q07955 (UniProtKB)
TAS
GO:0006406
Q07955 (UniProtKB)
TAS
GO:0016607
Q07955 (UniProtKB)
IDA
GO:0031124
Q07955 (UniProtKB)
TAS
GO:0044822
Q07955 (UniProtKB)
IDA
GO:0044822
Q07955 (UniProtKB)
IDA
GO:0050733
Q07955 (UniProtKB)
IEA
GO:0060048
Q07955 (UniProtKB)
IEA
GO:0070062
Q07955 (UniProtKB)
IDA
GO:0071013
Q07955 (UniProtKB)
IDA
GO:0035145
Q07955 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 SRSF1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neoplasm Metastasis 0.120542884 3 0 BeFree_CTD_human
Schizophrenia 0.12 1 0 CTD_human
HIV Infections 0.12 1 0 CTD_human
Non-Small Cell Lung Carcinoma 0.000814326 3 0 BeFree
Lung Neoplasms 0.000814326 3 0 BeFree
Adenocarcinoma of lung (disorder) 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree

基因相关服务

基因相关服务

联系方式

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