SPANXD (SPANX family member D)
- symbol:
- SPANXD
- locus group:
- protein-coding gene
- location:
- Xq27.2
- gene_family:
- alias symbol:
- CT11.4
- alias name:
- cancer/testis antigen family 11, m…
- entrez id:
- 64648
- ensembl gene id:
- ENSG00000196406
- ucsc gene id:
- uc004fbq.5
- refseq accession:
- NM_032417
- hgnc_id:
- HGNC:14332
- approved reserved:
- 2001-01-03
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014]
几种睾丸特异性基因短暂调节转录和翻译，需要启动一系列的雄性生殖细胞系必要的成熟精子形成的分子和形态的变化。此基因是SPANX家族的癌症/睾丸相关基因，它位于X染色体上的群集的SPANX基因编码的差异表达睾丸特异性蛋白质定位于各种亚细胞区室中的一员。这个特定基因编码与该核，但相关联的精子蛋白质，虽然在精子发生作用建议，该家族成员的特定功能还没有被确定。在这种基因多态性可能患有前列腺癌的易感性相关联。 [由RefSeq的，2014年4月提供]
基因本体信息
SPANXD基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
SPANXD基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Azoospermia | 0.002367032 | 1 | 0 | GAD |
| Oligospermia | 0.002367032 | 1 | 0 | GAD |
| Male infertility | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
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