SPANXC (SPANX family member C)
- symbol:
- SPANXC
- locus group:
- protein-coding gene
- location:
- Xq27.2
- gene_family:
- alias symbol:
- CTp11|CT11.3
- alias name:
- cancer/testis antigen family 11, m…
- entrez id:
- 64663
- ensembl gene id:
- ENSG00000198573
- ucsc gene id:
- uc033exl.2
- refseq accession:
- NM_022661
- hgnc_id:
- HGNC:14331
- approved reserved:
- 2001-01-03
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]
几种睾丸特异性基因短暂调节转录和翻译，需要启动一系列的雄性生殖细胞系必要的成熟精子形成的分子和形态的变化。此基因是SPANX家族，它位于X染色体上的基因簇的SPANX基因编码的差异表达睾丸特异性蛋白质定位于各种亚细胞区室中的一员。这个特定基因编码定位于核和高转移性细胞系中表达，使得该蛋白质的潜在的诊断和预后标志物的蛋白质。该蛋白属于家族癌症/睾丸抗原的和表示的癌症免疫治疗的潜在靶点。 [由RefSeq的，2008年7月提供]
基因本体信息
SPANXC基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
SPANXC基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| melanoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Systemic arterial pressure | 0.002367032 | 1 | 1 | GAD |
| Azoospermia | 0.002367032 | 1 | 0 | GAD |
| Blood pressure finding | 0.002367032 | 1 | 1 | GAD |
| Oligospermia | 0.002367032 | 1 | 0 | GAD |
| Male infertility | 0.002367032 | 1 | 0 | GAD |
| Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of testis | 0.000542884 | 2 | 0 | BeFree |
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