SOX11 (SRY-box transcription factor 11)

基因基本信息

基因基本信息

symbol:
SOX11
locus group:
protein-coding gene
location:
2p25.2
gene_family:
SRY (sex determining region Y)-boxes
alias symbol:
None
alias name:
SRY-related HMG-box gene 11
entrez id:
6664
ensembl gene id:
ENSG00000176887
ucsc gene id:
uc002qyj.3
refseq accession:
NM_003108
hgnc_id:
HGNC:11191
approved reserved:
1995-06-08

基因染色体位置

基因染色体位置

2p25.2
基因染色体位置图

基因简述

基因简述

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]

此内含子基因编码SOX的成员（SRY相关HMG盒）家族参与胚胎发育的调节，并在细胞命运的决心转录因子。所编码的蛋白质也可以在形成与其他蛋白质的蛋白复合物后充当转录调节。蛋白质可以在发育中的神经系统的功能和在肿瘤发生中发挥作用。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

SOX11基因的碱基突变：           仅显示部分snp
rs6721975       rs7602991       rs17362772       rs111322995       rs116648994       rs139885563       rs142646229       rs145657000       rs147020059       rs148622356       rs149438305       rs151305167       rs180692466       rs181823377       rs183761758       rs185053270       rs185218945      

基因表达

基因表达

SOX11基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AACGCAGGAAGATCATGGA
59
CAGCCTCTTGGAGATCTCG
59
TTTCTGGATGAGGACGACG
59
GTTTGATCTGCAGCTGCAG
59
ACGCAGGAAGATCATGGAG
59
CAGCCTCTTGGAGATCTCG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
SOX11
SPAST
Activation
22574173
SOX11
TUBB3
Unknown
21124928

基因本体信息

SOX11基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

SOX11基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000122
P35716 (UniProtKB)
IDA
GO:0000976
P35716 (UniProtKB)
ISS
GO:0000976
P35716 (UniProtKB)
ISS
GO:0000979
P35716 (UniProtKB)
IDA
GO:0001077
P35716 (UniProtKB)
ISS
GO:0001105
P35716 (UniProtKB)
ISS
GO:0001158
P35716 (UniProtKB)
IDA
GO:0001501
P35716 (UniProtKB)
ISS
GO:0001822
P35716 (UniProtKB)
IEA
GO:0001841
P35716 (UniProtKB)
ISS
GO:0002089
P35716 (UniProtKB)
ISS
GO:0003151
P35716 (UniProtKB)
ISS
GO:0003211
P35716 (UniProtKB)
ISS
GO:0003357
P35716 (UniProtKB)
ISS
GO:0003700
P35716 (UniProtKB)
ISS
GO:0005634
P35716 (UniProtKB)
IDA
GO:0005737
P35716 (UniProtKB)
IDA
GO:0006366
P35716 (UniProtKB)
IEA
GO:0006412
P35716 (UniProtKB)
IEA
GO:0008135
P35716 (UniProtKB)
IDA
GO:0008284
P35716 (UniProtKB)
ISS
GO:0010628
P35716 (UniProtKB)
IMP
GO:0010629
P35716 (UniProtKB)
IMP
GO:0014003
P35716 (UniProtKB)
IEA
GO:0014009
P35716 (UniProtKB)
ISS
GO:0014032
P35716 (UniProtKB)
ISS
GO:0017015
P35716 (UniProtKB)
IEP
GO:0021510
P35716 (UniProtKB)
ISS
GO:0021782
P35716 (UniProtKB)
ISS
GO:0030182
P35716 (UniProtKB)
IEP
GO:0030513
P35716 (UniProtKB)
ISS
GO:0035332
P35716 (UniProtKB)
ISS
GO:0035914
P35716 (UniProtKB)
IEA
GO:0045666
P35716 (UniProtKB)
IMP
GO:0045669
P35716 (UniProtKB)
IMP
GO:0045778
P35716 (UniProtKB)
IMP
GO:0045893
P35716 (UniProtKB)
ISS
GO:0045944
P35716 (UniProtKB)
IDA
GO:0046887
P35716 (UniProtKB)
ISS
GO:0048485
P35716 (UniProtKB)
ISS
GO:0048557
P35716 (UniProtKB)
ISS
GO:0048704
P35716 (UniProtKB)
ISS
GO:0050672
P35716 (UniProtKB)
IMP
GO:0050769
P35716 (UniProtKB)
ISS
GO:0060022
P35716 (UniProtKB)
ISS
GO:0060023
P35716 (UniProtKB)
ISS
GO:0060174
P35716 (UniProtKB)
ISS
GO:0060253
P35716 (UniProtKB)
IMP
GO:0060412
P35716 (UniProtKB)
ISS
GO:0060425
P35716 (UniProtKB)
ISS
GO:0060548
P35716 (UniProtKB)
ISS
GO:0060563
P35716 (UniProtKB)
ISS
GO:0061029
P35716 (UniProtKB)
ISS
GO:0061053
P35716 (UniProtKB)
ISS
GO:0061303
P35716 (UniProtKB)
ISS
GO:0061386
P35716 (UniProtKB)
ISS
GO:0072395
P35716 (UniProtKB)
IEP
GO:2000648
P35716 (UniProtKB)
IMP
GO:2000678
P35716 (UniProtKB)
ISS
GO:2001111
P35716 (UniProtKB)
ISS

基因相关microRNA

基因相关microRNA

可能调控 SOX11基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Coffin-Siris syndrome 0.120271442 1 0 BeFree_ORPHANET
Salivary Gland Neoplasms 0.12 1 0 CTD_human
Neoplasm Invasiveness 0.12 1 0 CTD_human
MENTAL RETARDATION, AUTOSOMAL DOMINANT 27 0.12 1 0 UNIPROT
Adenoid Cystic Carcinoma 0.12 1 0 CTD_human
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 0.006786047 25 0 BeFree
Male infertility 0.00272435 1 0 LHGDN
Creatinine finding 0.002367032 1 1 GAD
Kidney Diseases 0.002367032 1 1 GAD
Blood pressure finding 0.002367032 1 1 GAD

基因相关服务

基因相关服务

联系方式

山东省济南市 高新区 崇华路359号 三庆世纪财富中心C1115室

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2